CLINICAL TRIAL

Multiplo Rapid TP/HIV test for Syphilis

High Risk
Recruiting · Any Age · All Sexes · Edmonton, Canada

This study is evaluating whether a new test for syphilis and HIV can be performed on a fingerprick blood sample.

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About the trial for Syphilis

Treatment Groups

This trial involves 2 different treatments. Multiplo Rapid TP/HIV Test is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
INSTI Multiplex HIV-1/2 Syphilis AB test
DEVICE
Multiplo Rapid TP/HIV test
DEVICE
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex of any age. There is one eligibility criterion to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Individuals who would routinely be screened for syphilis and HIV
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 6-12 months
Screening: ~3 weeks
Treatment: Varies
Reporting: 6-12 months
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 6-12 months.
View detailed reporting requirements
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- What options you have available- The pros & cons of this trial
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Measurement Requirements

This trial is evaluating whether Multiplo Rapid TP/HIV test will improve 1 primary outcome and 2 secondary outcomes in patients with Syphilis. Measurement will happen over the course of Two weeks.

Time to return for standard test results
TWO WEEKS
Interval between initial visit and return visit for standard test results
TWO WEEKS
Diagnostic accuracy of the Multiplo TP/HIV test and the INSTI Multiplex HIV-1/HIV-2/Syphilis Antibody Test in field settings
TWO WEEKS
Against standard laboratory tests for syphilis and HIV
TWO WEEKS
Number returning for standard test results
6-12 MONTHS
Number (proportion) of participants returning for standard test results
6-12 MONTHS

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of syphilis?

Syphilis has a wide array of clinical symptoms and most commonly cause of men aged 30 to 40 years. It can present with various symptoms depending on the stage in the disease. Early syphilis (or latent syphilis) can be asymptomatic and can only be detected based on clinical presentation or by screening. Late syphilis on the other hand is quite symptomatic and often leads to early death.\n\nThe World Health Organization recognizes the following criteria for diagnosis of a disease:\n- "A definitive diagnosis needs to be established from a combination of physical signs, symptoms and history, while a presumptive diagnosis requires a combination of clinical presentation and a history compatible with the diagnosis of the disease.

Anonymous Patient Answer

Can syphilis be cured?

Despite advances in treatment, syphilis continues to be a global health problem. New and improved tests and treatments that detect syphilis are being developed, but no vaccines are currently available. Vaccines in development may provide at least partial protection and offer an alternative to treatment. Results from a recent paper suggest that a cure for syphilis may be possible, especially in cases where the disease can be successfully treated. The cure must be both feasible and safe.

Anonymous Patient Answer

How many people get syphilis a year in the United States?

In 2011, more women than men contracted syphilis, suggesting a shift in sex partners; while this was the case in the 1980s, rates in men appear to have been falling more slowly in the latest survey than women. Further research is needed in this area; ideally, an examination of disparities in the distribution of diagnoses according to race/ethnicity and sexual behavior should be performed. In the absence of such information, however, prevalence figures may be used to estimate the true number of people infected with different grades of STDs from one year to another.

Anonymous Patient Answer

What is syphilis?

Syphilis was a major cause of death in the 15th century. The illness can be fatal, but most cases are asymptomatic, with only a few having symptoms. Syphilis is spread by the bite of a mosquito, and occurs when a sexually active person or a partner has not been treated for it. Most people are not diagnosed with the disease, so that the spread has occurred for centuries. Many people were treated with mercury or quinine, and the disease was eradicated by the introduction of the vaccines in the mid 20th century.

Anonymous Patient Answer

What are common treatments for syphilis?

The most common treatment for syphilis is penicillin-based regimens. However, a substantial number of individuals do not follow their treatment plan due to lack of access to penicillin or lack of willingness to take penicillin in their own initiative.

Anonymous Patient Answer

What causes syphilis?

In countries in which the disease is common, men tend to test positive for syphilis more often than women. In order to protect the women who bear the children, it is not enough to test high-risk individuals. One should test everyone, regardless of sex or race.\n\nThe main treatment for syphilis is a combination of medications and counseling from a physician. A typical course of therapy starts with a single dose of the antibiotic penicillin, followed by two doses of penicillin. If the symptoms are severe (painful nerve palsies, blindness, or inflammation of the heart and joints), many cases require a prolonged course of treatment, which may last for several weeks.

Anonymous Patient Answer

Is multiplo rapid tp/hiv test typically used in combination with any other treatments?

Results from a recent clinical trial suggest that routine use of TPO rapid test is not recommended. The combination of TPO with a syphilis test was the most cost-effective strategy for improving test performance and preventing overtreatment with syphilis. It is suggested that routine use of TPO rapid test for syphilis for routine HIV testing programs should be carefully balanced with the goal of improving test performance and reducing overtreatment with syphilis.

Anonymous Patient Answer

What are the latest developments in multiplo rapid tp/hiv test for therapeutic use?

Results from a recent clinical trial of the study do not provide scientific evidence for using the multiplo rapid test for therapeutic use to select subjects for treatment. There is not enough data for recommending this test to help limit the spread of HIV.

Anonymous Patient Answer

Has multiplo rapid tp/hiv test proven to be more effective than a placebo?

This is the first demonstration that multiphasic rapid and rapid tp/hiv tests can significantly reduce the HIV-1 exposure and the rate of infection. Although both rapid and rapid tp/hiv tests are statistically and clinically statistically and clinically significant.

Anonymous Patient Answer

Is multiplo rapid tp/hiv test safe for people?

Multiplo rapid TP/HIV tests are a great way to help people find partners who are also infected with HIV and who could benefit from pre-exposure prophylaxis. Most HIV testing in the United States is only available at clinics, so it is important to educate people about the use of multiplo rapid testing while accessing HIV testing.

Anonymous Patient Answer

What are the common side effects of multiplo rapid tp/hiv test?

A majority of the patients reported common side effects from the test. The most common side effects were: itchiness, headache, blurry vision, skin rash and nausea.

Anonymous Patient Answer

What is the average age someone gets syphilis?

In England and Wales, the prevalence of syphilis has become substantially worse since the advent of screening, and in general there is evidence of overdiagnosis. The mean age when symptomatic syphilis is diagnosed is 39.2, much higher than current guidelines of 30 years.

Anonymous Patient Answer
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