← Back to Search

Other

L-Citrulline Supplementation for Metabolic Syndrome

Q: Does the research project have an upper age limit restriction?

To be eligible for this clinical study, participants must be aged 45 to 79. Separately, there are 392 trials available to people below 18 years old and 1128 experiments designed for seniors over 65.

Q: What is the intended outcome of this experiment?

This 4 week trial has the primary aim of measuring microvascular endothelial functioning in a fasted state. Secondary objectives include analyzing baseline and post supplementation levels of serum L-arginine, arginase, and nitric oxide.

Q: Is there still room for participants in this experiment?

Per the information available on clinicaltrials.gov, this clinical trial is enrolling participants as we speak. The primary posting took place in January of 2023 and was edited most recently at the end of August that same year.

Q: Which individuals meet the qualifications for this research endeavor?

To be considered for this trial, individuals must have metabolic syndrome and fit within the age range of 45 to 79 years old. The study is projected to enrol 24 participants.

Q: How many participants are being enrolled into this trial?

Affirmative. The clinical trial listings on clinicialtrials.gov denote that this research was initialised on January 1st, 2023 and has since been updated as recent as August 29th, 2023. In total 24 patients are being sought out from a single medical centre for the purposes of the study.

N/A

Recruiting

Led By Arturo Figueroa

Research Sponsored by Texas Tech University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Must present at least 3 of the following 5 cardiometabolic risk factors: Waist circumference ≥88 cm, Fasting glucose between 100-125 mg/dL or HbA1c between 5.7-6.4%, Blood pressure ≥130 mm Hg, Triglyceride ≥ 150 mg/dL, HDL <50 mg/dL

Women aged 45-79 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 4 weeks

Awards & highlights

Study Summary

This trial seeks to prove that a supplement can improve vascular health for women with metabolic syndrome.

Who is the study for?

This trial is for sedentary women aged 45-79 with metabolic syndrome, who don't smoke or drink heavily. They must have at least three of these: a waist size ≥88 cm, fasting glucose between 100-125 mg/dL or HbA1c between 5.7-6.4%, high blood pressure (≥130 mm Hg), high triglycerides (≥150 mg/dL), and low HDL (<50 mg/dL). BMI must be ≤39.9 kg/m2.Check my eligibility

What is being tested?

The study tests if L-citrulline supplements can improve blood vessel function in middle-aged and older women with metabolic syndrome, especially when their blood sugar is high after eating. Participants will either receive the supplement or a placebo to compare effects.See study design

What are the potential side effects?

While not specified here, common side effects of L-citrulline may include stomach discomfort, heartburn, changes in urination patterns, or an imbalance in electrolytes if taken excessively.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have at least 3 of these: large waist, high sugar, high blood pressure, high triglycerides, or low HDL.

Select...

I am a woman aged between 45 and 79.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 4 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~4 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

24-hour ambulatory blood pressure monitoring

Blood pressure during acute hyperglycemia

Blood pressure in the fasted condition

+11 more

Secondary outcome measures

Serum Endothelin-1 levels

Serum Nitric Oxide levels

Serum arginase levels

+2 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: PlaceboExperimental Treatment1 Intervention

Microcrystalline Cellulose

Group II: L-citrullineExperimental Treatment1 Intervention

L-citrulline: 10 grams/day

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Placebo

1995

Completed Phase 3

~2670

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Texas Tech UniversityLead Sponsor

81 Previous Clinical Trials

9,140 Total Patients Enrolled

4 Trials studying Menopause

113 Patients Enrolled for Menopause

Arturo FigueroaPrincipal InvestigatorTexas Tech University

5 Previous Clinical Trials

150 Total Patients Enrolled

3 Trials studying Menopause

74 Patients Enrolled for Menopause

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the research project have an upper age limit restriction?

"To be eligible for this clinical study, participants must be aged 45 to 79. Separately, there are 392 trials available to people below 18 years old and 1128 experiments designed for seniors over 65."

Answered by AI

What is the intended outcome of this experiment?

"This 4 week trial has the primary aim of measuring microvascular endothelial functioning in a fasted state. Secondary objectives include analyzing baseline and post supplementation levels of serum L-arginine, arginase, and nitric oxide."

Answered by AI

Is there still room for participants in this experiment?

"Per the information available on clinicaltrials.gov, this clinical trial is enrolling participants as we speak. The primary posting took place in January of 2023 and was edited most recently at the end of August that same year."

Answered by AI

Which individuals meet the qualifications for this research endeavor?

"To be considered for this trial, individuals must have metabolic syndrome and fit within the age range of 45 to 79 years old. The study is projected to enrol 24 participants."

Answered by AI

How many participants are being enrolled into this trial?

"Affirmative. The clinical trial listings on clinicialtrials.gov denote that this research was initialised on January 1st, 2023 and has since been updated as recent as August 29th, 2023. In total 24 patients are being sought out from a single medical centre for the purposes of the study."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effects of L-citrulline Supplementation on Vascular Function in Metabolic Syndrome

Arturo Figueroa 2023. "Effects of L-citrulline Supplementation on Vascular Function in Metabolic Syndrome". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06025357.

All > Metabolic Syndrome > Menopause