Treatment for Down Syndrome

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
VUMC Bill Wilkerson Center, Nashville, TN
Down Syndrome+2 More
Eligibility
< 18
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether speech recast therapy can improve speech intelligibility in children with Down syndrome.

See full description

Eligible Conditions

  • Down Syndrome
  • Speech Intelligibility Intervention in Down Syndrome

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 2 primary outcomes and 1 secondary outcome in patients with Down Syndrome. Measurement will happen over the course of six months.

six months
Speech Accuracy
Speech Intelligibility
Speech Rate

Trial Safety

Safety Estimate

1 of 3

Trial Design

0 Treatment Group

This trial requires 20 total participants across 0 different treatment group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: six months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly six months for reporting.

Who is running the study

Principal Investigator
S. C.
Prof. Stephen Camarata, Professor, Hearing and Speech Sciences
Vanderbilt University Medical Center

Closest Location

VUMC Bill Wilkerson Center - Nashville, TN

Eligibility Criteria

This trial is for patients born any sex aged 18 and younger. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Parents reported that their children used 3-word utterances regularly show original
The developmental stage from 6-14 years old is called the chronological age. show original
Down Syndrome is a disorder that is typically identified by previous medical examinations show original
The participants in the project will have a hearing screening at the time of enrollment to ensure that their hearing is at least 25 dB at 1000, 2000, and 4000 Hz. show original

Patient Q&A Section

Can down syndrome be cured?

"It is indeed possible for people with DS to improve their lives with adequate support with the right strategy. Even though there are few successes of cured DS, there are also very many successful down syndrome adults. If a person with DS wants to become healthier, they need to take care to avoid and minimize alcohol or drug use and to do enough exercises to keep themselves active. If a person with DS wishes to marry or become a single mom with no family or partner they need to be prepared psychologically if the marriage or childbearing fail. Even though there are no cures, it is important to work hard and to remember that any treatment for DS is only of no use if people aren’t motivated to commit to their treatment." - Anonymous Online Contributor

Unverified Answer

What are common treatments for down syndrome?

"Down syndrome is diagnosed in about one in 3000 births. It can be treated with supportive, nonspecific medical and behavioral therapy and surgery. The most aggressive treatment is complete resection of the tumor and adjacent tissues, followed by chemotherapy. This should be performed in the absence of indications to avoid the risk of developing leukemia in this genetic condition." - Anonymous Online Contributor

Unverified Answer

What is down syndrome?

"Down syndrome is a human chromosome disorder caused by a missing (deletion) or abnormal (duplication) portion of 23 chromosome 21, one of the 23 pairs of chromosomes in the human genome. Down syndrome is characterized by physical, cognitive, behavioural and psychosocial aspects. Most children have one extra copy of genes located on a part of human chromosome 21 called segment 21q22. Down syndrome is not to be confused with other disorders involving a derivative of chromosome 21, e.g. 22q13.3 deletion syndrome. Down syndrome occurs when the mother has a carrier chromosome and passes a defective copy of chromosome 21 (trisomy 21) to the person in the form of her egg or sperm." - Anonymous Online Contributor

Unverified Answer

What are the signs of down syndrome?

"Data from a recent study suggest that the signs of Down syndrome begin to develop in the third trimester of a mother’s pregnancy, thus supporting the notion that Down syndrome is a fetal aging defect. The manifestations of Down syndrome begin to appear earlier in women with trisomy 21 than in women with trisomy 18." - Anonymous Online Contributor

Unverified Answer

How many people get down syndrome a year in the United States?

"Approximately 1 in 400 individuals has Down's syndrome. Rates are similar in both black and white families, but the male-to-female ratio is 2:1 in Down's syndrome." - Anonymous Online Contributor

Unverified Answer

What causes down syndrome?

"A significant part of DS cases are the result of spontaneous genetic mutations during the mother's development before birth. Some babies with Down syndrome are conceived after conception through sexual intercourse and the father has not had a previous child with DS. The father's family will not have Down syndrome or any other genetic disorders after him. Hence in some cases, people with Down syndrome will not necessarily have parents with Down syndrome. Moreover, DS is the most common birth defect in the world, resulting in almost 1,000,000 cases of Down syndrome every year worldwide. Therefore, DS can be attributed as an anomaly in the conception, pregnancy, birth and development of human beings." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in treatment for therapeutic use?

"The development of new treatments for Down syndrome is continuing at an impressive rate. It is important for consumers and providers to be aware of current medications and their relative safety and effectiveness." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets down syndrome?

"It is a question that should only be answered if the questioner is a professional with an adequate understanding of the condition. Because this disease is so prevalent, most medical facilities will have seen more than one case of the condition in the past. It may also be a question that can be answered after having reviewed the whole family. It is possible there are children born without the ability that have been aborted who are Down's Syndrome, a condition that has been seen in the US lately as well as the common Down Syndrome has been seen in the UK the last 2 years. Hence, the average age a person goes down could be 7.5 years for males and 7.0 years for females." - Anonymous Online Contributor

Unverified Answer

What is treatment?

"I think treatment is a necessity but not only a requisite- to meet a person's needs is better than to be a prisoner of a system because there have been too many abuses in the past from which a better-informed, healthier people's can be obtained and kept. Because you can find this type of people very well with Down Syndrome, because all these people are extremely peaceful and easy-going and have a genuine need in themselves to communicate comfortably with others. You do that with kindness and unconditional love (a person's needs), not just a cure\n" - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for down syndrome?

"Clinical trials should not be considered to be justified for any of the disorders with documented associations with Down syndrome, unless the trial results are intended to affect law, policy, or medical practice in a public interest context." - Anonymous Online Contributor

Unverified Answer

What does treatment usually treat?

"Aspects of the DS, such as cognition have been described as a specific treatment. There can be a clear link between aspects of cognitive deficits and social behaviors. The treatment can focus at the core of aspects that differ in patients' functioning and that affect the behavior in a social environment. There seems to be a need for specific educational interventions, as well as interventions for physical activity of this type has been described as a preventive approach. It is important to note, that therapies are used that are tailored to each individual’s capabilities and interests. The therapists must have a good understanding of the developmental disabilities, the type of disabilities and the strengths and weaknesses of the individual with DS." - Anonymous Online Contributor

Unverified Answer

Does treatment improve quality of life for those with down syndrome?

"Results from a recent clinical trial are indicative of the quality of life of those with DS. Their quality of life is influenced by family members (who are often not parents themselves), as well as socioeconomic and environmental factors that effect their community and their lives as a whole. Results from a recent clinical trial in this study indicate a need to expand the existing mental health resources to include treatment for adolescents and their providers. More specifically, a clearer definition needs to be developed and implemented for early diagnosis and intervention." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Down Syndrome by sharing your contact details with the study coordinator.