TLR4 and TOPK/PRPK Signaling in Sun Damaged Human Skin Acutely Exposed to Solar Simulated Light for Sun Damaged Skin

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Arizona, Tucson, AZ
Sun Damaged Skin+1 More
Solar Simulated Light (SSL) - Other
Eligibility
18+
All Sexes
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Study Summary

The purpose of this project is to obtain clinical data, including skin samples, that will help investigators evaluate changes occurring in sun damaged human skin as a result of light that simulates sun exposure (Solar Simulated Light). Of specific interest are the molecular targets for cancer prevention. Molecular targets are the parts of the body's cells that have been shown to play a role in causing or preventing cancer and which scientists seek to affect in a way that may slow or eliminate the development of cancer.

Eligible Conditions

  • Sun Damaged Skin

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

2 Primary · 1 Secondary · Reporting Duration: Baseline (pre-SSL exposure) and post-SSL exposure (at 5hr and 24hr post-exposure).

Baseline (pre-SSL exposure) and post-SSL exposure (at 5hr and 24hr post-exposure).
Exploratory Endpoint: To assess the correlation between skin sun damage level and the magnitude of solar simulated light-induced pathway activation.
Changes from baseline (pre-SSL exposure) to post-SSL exposure (at 5hr and 24hr post-exposure).
Primary Endpoint: To assess changes in skin cancer signaling pathway activation levels pre-solar simulated light exposure (baseline) and 5hr and 24hr post-solar simulated light exposure in sun damaged skin.
To assess changes in skin cancer signaling pathway activation levels pre-solar simulated light exposure (baseline) and 5hr and 24hr post-solar simulated light exposure in sun damaged skin.

Trial Safety

Safety Progress

1 of 3

Trial Design

1 Treatment Group

TLR4 and TOPK/PRPK Signaling in Sun Damaged Human Skin Acutely Exposed to Solar ...
1 of 1
Experimental Treatment

36 Total Participants · 1 Treatment Group

Primary Treatment: TLR4 and TOPK/PRPK Signaling in Sun Damaged Human Skin Acutely Exposed to Solar Simulated Light · No Placebo Group · N/A

TLR4 and TOPK/PRPK Signaling in Sun Damaged Human Skin Acutely Exposed to Solar Simulated Light
Other
Experimental Group · 1 Intervention: Solar Simulated Light (SSL) · Intervention Types: Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline (pre-ssl exposure) and post-ssl exposure (at 5hr and 24hr post-exposure).
Closest Location: University of Arizona · Tucson, AZ
Photo of az university of arizona  1Photo of az university of arizona  2Photo of tucson  3
2002First Recorded Clinical Trial
1 TrialsResearching Sun Damaged Skin
240 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 5 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are a healthy individual.\n
You are willing to limit sun exposure to the body during the study period and agree to wear protective clothing when you are outdoors.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.