TAU (treatment as usual) for Suicidal Ideation

Phase-Based Estimates
1
Effectiveness
1
Safety
University of Pittsburgh, Pittsburgh, PA
Suicidal Ideation+2 More
TAU (treatment as usual) - Behavioral
Eligibility
< 18
All Sexes
Eligible conditions
Suicidal Ideation

Study Summary

This study is evaluating whether a combination of a therapy and a phone app may help reduce suicidal thoughts in adolescents.

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Eligible Conditions

  • Suicidal Ideation
  • Parasuicide
  • Suicide
  • Suicide, Attempted

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether TAU (treatment as usual) will improve 1 primary outcome in patients with Suicidal Ideation. Measurement will happen over the course of 1 - 24 weeks.

1 - 24 weeks
Columbia Suicide Severity Rating Scale (C-SSRS)

Trial Safety

Safety Estimate

1 of 3

Trial Design

4 Treatment Groups

TAU (treatment as usual) alone
ASAP + TAU (treatment as usual)

This trial requires 240 total participants across 4 different treatment groups

This trial involves 4 different treatments. TAU (treatment As Usual) is the primary treatment being studied. Participants will be divided into 3 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

ASAP + TAU (treatment as usual)Participants in this arm will receive the ASAP (As Safe As Possible) intervention during their transition from inpatient to outpatient care, in addition to usual treatment protocols that all adolescents admitted to their respective Inpatient Psychiatry program receive. Participants complete paper safety plans as part of their regular treatment, which is a standard of care for suicidal youth.
ASAP + BRITE + TAU (treatment as usual)Participants in this arm receive the ASAP (As Safe As Possible) intervention, during their transition from inpatient to outpatient care, as well as the BRITE smart phone app for distress tolerance/emotion regulation and safety planning. Participants will also receive usual treatment protocols that all adolescents admitted to their respective Inpatient Psychiatry program receive. Participants complete paper safety plans as part of their regular treatment, which is a standard of care for suicidal youth.
BRITE + TAU (treatment as usual)Participants in this arm will receive the BRITE smart phone app for distress tolerance/emotion regulation and safety planning as they proceed from inpatient to outpatient care, in addition to usual treatment protocols that all adolescents admitted to their respective Inpatient Psychiatry program receive. Participants complete paper safety plans as part of their regular treatment, which is a standard of care for suicidal youth.
TAU (treatment as usual) alone
Behavioral
Participants in this grouping are studied as they proceed from inpatient to outpatient care, per usual treatment protocols at each site. Participants complete paper safety plans as part of their regular treatment, which is a standard of care for suicidal youth.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 1 - 24 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 1 - 24 weeks for reporting.

Who is running the study

Principal Investigator
B. K.
Prof. Beth Kennard, PROFESSOR
University of Texas Southwestern Medical Center

Closest Location

University of Pittsburgh - Pittsburgh, PA

Eligibility Criteria

This trial is for patients born any sex aged 18 and younger. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
The young person and their parent are able to complete assessments in English, and the young person is able to complete therapy. show original
The study focused on young people admitted to an inpatient unit for a recent suicide attempt or significant suicidal ideation. show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can suicidal ideation be cured?

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The suicidal ideation of a loved one may be successfully cured, while the suicidal ideation of a stranger may be permanent and cannot be cured.

Unverified Answer

What are common treatments for suicidal ideation?

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Suicidal ideation is more likely to be treated for depression, anxiety, or substance use disorders than for anxiety or substance use disorders of their own accord. If the treatment is primarily aimed at alleviating symptoms, these treatments are not necessarily more effective at reducing the frequency of suicidality than psychotherapy aimed directly at reducing these underlying disorders. Nevertheless, the frequency of individuals with suicidality who have a substance use disorder suggests that it merits attention for prevention.

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How many people get suicidal ideation a year in the United States?

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More than 1.2 million people in the United States have suicidal ideation every year. If it is to be treated appropriately, many of these people may not seek treatment because of the stigma associated with suicidal thoughts and behaviors.

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What are the signs of suicidal ideation?

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Signs of suicidal ideation include a family history of mental illness, a question about wanting to die, a thought about wanting to commit suicide, a plan to commit suicide, and recent suicidal attempts. In a recent study, findings, signs of ideation were independent of mental disorders.

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What causes suicidal ideation?

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The [categorical] association between depressive symptoms and suicidal ideation is complex. To more effectively detect high-risk individuals who may need further evaluation and treatment, assessment of depressive symptoms must be integrated into the clinical assessment of suicidal ideation and depression.

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What is suicidal ideation?

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In adolescents, suicidal ideation is a common phenomenon, often precipitated by personal or peer problems. In order to effectively treat this condition, clinicians and educators need to have knowledge about the common clinical features and mental health services available for such patients.

Unverified Answer

What are the latest developments in tau (treatment as usual) for therapeutic use?

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The development of tau for therapeutic use is not a new challenge. The new treatment of tau will require that the therapist and the patient have specific training and will take account of the patient's condition.

Unverified Answer

What are the common side effects of tau (treatment as usual)?

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Some patients may benefit from adding behavioral counseling to a typical cognitive-behavioral (cognitive-behavioral therapy/experiencing with structured training and ongoing assistance), or 'treatment as usual'. The effects of tau (treatment as usual) on the occurrence of any one side effect is also uncertain and requires further study.

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Have there been other clinical trials involving tau (treatment as usual)?

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There has been one placebo-controlled trial in New Zealand (New Zealand Cancer Research Foundation, 2002). It was on low quality, as it did not specify any inclusion or exclusion criteria, had no power analysis, and no rationale for the randomisation. There is no information available on the trial. However, one more trial has been completed involving tau (treatment as usual) for suicidal ideation, and that was a low-quality trial that did not contain a power analysis. So, as there was no high-quality study in which clinical outcomes (e.g., quality of life, hopelessness, recovery) were the primary outcomes, it can be said that it is not ethical to use tau as treatment strategy.

Unverified Answer

Have there been any new discoveries for treating suicidal ideation?

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There is only limited evidence that cognitive behavioral therapy is superior to interpersonal psychotherapy for reducing suicidal ideation. There is, however, good evidence that antidepressant medications are effective for treating suicidal ideation. There is no evidence to support the role of antipsychotic medications in reducing suicidal ideation. There was very limited evidence that antiepileptic medications are effective for treating suicidal ideation.

Unverified Answer

Is tau (treatment as usual) typically used in combination with any other treatments?

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There are many different treatments available for suicidal patients. They are used in combination with each other to reduce the severity of suicidal ideation and decrease suicidal behaviours.

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Is tau (treatment as usual) safe for people?

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There is ongoing concern about possible adverse events associated with tau maintenance. The present study did not find any evidence of increased fatal or non-fatal adverse events for any treatment group. However, there was a greater incidence of suicide attempts in the tau versus control group. It did raise important questions regarding the safety of tau therapies and their effectiveness in the treatment of psychosis.

Unverified Answer
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