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Behavioural Intervention

Smoking Abstinence for Nicotine Withdrawal (NicWith Trial)

N/A
Recruiting
Research Sponsored by University of Oklahoma
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 21-55
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2-4 weeks
Awards & highlights

NicWith Trial Summary

This trial will study how smoking affects the brain's response to pleasure and if this impacts smokers' behavior.

Who is the study for?
This trial is for healthy adults aged 21-55 who smoke at least 10 cigarettes daily for over a year, are right-handed, and have a smartphone. They should not be seeking smoking cessation treatment or using other nicotine products frequently. Participants must also be free from significant health issues like heart disease, uncontrolled blood pressure, severe respiratory conditions, and certain mental health disorders.Check my eligibility
What is being tested?
The study investigates how abstaining from smoking versus regular smoking affects brain response to pleasure. It involves two MRI scans—one after not smoking for a day and another after usual smoking—followed by daily questionnaires via phone app for two weeks.See study design
What are the potential side effects?
There may not be direct side effects from the interventions since they involve normal behavior (smoking) and abstinence. However, participants might experience discomfort or anxiety during MRI scanning or withdrawal symptoms such as irritability and cravings when abstaining.

NicWith Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 21 and 55 years old.

NicWith Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2-4 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2-4 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Blood Oxygen Level Dependent (BOLD) Activation
Ecological Momentary Assessment (EMA) Pleasure Ratings

NicWith Trial Design

2Treatment groups
Experimental Treatment
Group I: Smoking AbstinenceExperimental Treatment1 Intervention
Participants will abstain from smoking for 24 hours before one MRI scan. Smoking abstinence will be confirmed using exhaled carbon monoxide breath testing
Group II: Ad Lib SmokingExperimental Treatment1 Intervention
Participants will continue smoking as usual (i.e. "ad lib") before one MRI scan and smoke one additional cigarette immediately prior to scanning. Continued smoking will be confirmed using exhaled carbon monoxide breath testing.

Find a Location

Who is running the clinical trial?

University of OklahomaLead Sponsor
455 Previous Clinical Trials
97,460 Total Patients Enrolled
Oklahoma State UniversityOTHER
46 Previous Clinical Trials
8,122 Total Patients Enrolled
National Institutes of Health (NIH)NIH
2,697 Previous Clinical Trials
7,492,447 Total Patients Enrolled
3 Trials studying Nicotine Addiction
327 Patients Enrolled for Nicotine Addiction

Media Library

Smoking Abstinence (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05041959 — N/A
Nicotine Addiction Research Study Groups: Smoking Abstinence, Ad Lib Smoking
Nicotine Addiction Clinical Trial 2023: Smoking Abstinence Highlights & Side Effects. Trial Name: NCT05041959 — N/A
Smoking Abstinence (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05041959 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Would I be eligible for this study if I am over 55 years old?

"The age range that this trial is willing to accept starts at 21 years old and ends at 55 years old."

Answered by AI

How many people are being studied in this clinical trial at one time?

"The listing for this clinical trial on clinicaltrials.gov verifies that the study is actively recruiting patients. This particular trial was posted on 6/2/2022 and was last updated on 6/10/2022. They are looking for a total of 70 individuals from 1 location to participate."

Answered by AI

Which type of patients would be most eligible for this clinical trial?

"This research is looking for around seventy individuals who currently smoke cigarettes and are between 21 and 55 years old."

Answered by AI

Are there any open enrollments for this particular clinical trial?

"The trial, which was first announced on June 2nd, is still looking for patients. The most recent update to the study was on June 10th."

Answered by AI

Who else is applying?

What site did they apply to?
Hardesty Center for Clinical Research and Neuroscience
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Nicotine Withdrawal and Reward Processing
2022. "Nicotine Withdrawal and Reward Processing". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05041959.
~18 spots leftby Aug 2024
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