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Non-invasive Brain Stimulation

Active repetitive transcranial magnetic stimulation (rTMS) for Opioid Use Disorder

N/A
Waitlist Available
Led By Kathryn Biernacki, PhD
Research Sponsored by Rutgers University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 0 (day of testing)
Awards & highlights

Study Summary

This trial will study the effects of transcranial magnetic stimulation (TMS) on reward processing in people with opioid use disorder (OUD). TMS is a noninvasive brain stimulation technique that uses magnetic fields to stimulate nerve cells in the brain. The investigators will use TMS to see if it can improve cognitive control in OUD. This study will be a randomized, sham-controlled trial, which means that half of the participants will receive active TMS and half will receive a sham (fake) TMS. The investigators hypothesize that Ri-TMS will be successful in modulating the reward positivity in opioid users in the active

Eligible Conditions
  • Opioid Use Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 0 (day of testing)
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 0 (day of testing) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Reward Positivity

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Active TMS - OUDExperimental Treatment1 Intervention
Participants in the opioid used disorder group (OUD) in the active condition will receive repetitive TMS (rTMS), delivered at 110% of participants' resting motor threshold at 10 Hz continuously over the predefined DLFPC target for a total of 2000 pulses
Group II: Active TMS - HCActive Control1 Intervention
Healthy Control (HC) participants in the active condition will receive repetitive TMS (rTMS), delivered at 110% of participants' resting motor threshold at 10 Hz continuously over the predefined DLFPC target for a total of 2000 pulses
Group III: Sham TMS - HCPlacebo Group1 Intervention
Identical parameters will be applied to the healthy control (HC) SHAM group with the exception that the TMS coil will be flipped 180º to mimic auditory stimulation
Group IV: Sham TMS - OUDPlacebo Group1 Intervention
Identical parameters will be applied to the opioid used disorder (OUD) SHAM group with the exception that the TMS coil will be flipped 180º to mimic auditory stimulation
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Active repetitive transcranial magnetic stimulation (rTMS)
2020
N/A
~90

Find a Location

Who is running the clinical trial?

Rutgers UniversityLead Sponsor
113 Previous Clinical Trials
2,804,012 Total Patients Enrolled
Kathryn Biernacki, PhDPrincipal Investigator - Rutgers University - Newark
Rutgers University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any openings for enrolment in this research trial?

"The most recent information on clinicaltrials.gov indicates that the recruitment phase of this medical trial has concluded, having first been posted in February 2020 and then updated lastly in September 2022. However, 535 other trials are at present seeking out patients to enrol."

Answered by AI

What are the eligibility criteria for participating in this clinical experiment?

"This research is recruiting 60 people, aged 18 to 55 that struggle with drug abuse. To be eligible, applicants must meet the following requirements: Opioid dependent individuals (per Alcohol, Smoking and Substance Involvement Screening Test opioid dependence score), or Healthy controls without a significant prior substance use history; Male & Female between 18-55 years old; Willingness and capacity to provide either verbal or written consent in regards to participation."

Answered by AI

Does this research include participants aged 55 or older?

"This research is accepting participants aged between 18 and 55 years old."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Using Combined EEG and Non-invasive Brain Stimulation to Examine and Improve Reward Functioning in Opioid Use Disorder
Travis Baker, PhD 2020. "Using Combined EEG and Non-invasive Brain Stimulation to Examine and Improve Reward Functioning in Opioid Use Disorder". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04432493.
~16 spots leftby Apr 2025
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