Direct Transfer vs Conventional Triage for Stroke
(DIRECT Trial)
Trial Summary
Do I need to stop taking my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Direct Transfer to Angiography Suite (DTAS) for stroke?
Research shows that DTAS can improve outcomes for stroke patients by reducing the time to treatment, which is crucial for minimizing brain damage. Studies found that patients transferred directly to the angiography suite had faster treatment times and better recovery outcomes compared to those who went through conventional triage processes.12345
Is Direct Transfer to Angiography Suite (DTAS) safe for stroke patients?
How does the Direct Transfer to Angiography Suite (DTAS) treatment for stroke differ from other treatments?
The Direct Transfer to Angiography Suite (DTAS) treatment for stroke is unique because it involves taking patients directly to the angiography suite for treatment without stopping for initial imaging tests like a CT scan. This approach aims to reduce the time to treatment, potentially improving outcomes by allowing faster access to endovascular therapy, which is crucial for patients with large vessel occlusion strokes.13468
What is the purpose of this trial?
The purpose of this study is to compare two strategies for treating adults with suspected large vessel occlusion stroke within 7 hours of symptom onset. Researchers will evaluate whether direct transfer to the neurointerventional angiography suite improves recovery and reduces disability compared to the conventional approach of first being evaluated in the emergency department. The study will also assess safety and other health outcomes to guide care for stroke patients.
Research Team
Santiago Ortega, MD
Principal Investigator
University of Iowa
Tudor Jovin, MD
Principal Investigator
Cooper University Health Care
Eligibility Criteria
Adults who've had a stroke caused by a large vessel blockage in the brain within the past 7 hours can join. The trial is testing if going straight to an angiography suite helps more than the usual emergency room evaluation first.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either direct transfer to the neurointerventional angiography suite or conventional evaluation in the emergency department followed by mechanical thrombectomy if eligible
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments of global disability, functional independence, and quality of life
Long-term Follow-up
Additional monitoring of health outcomes and healthcare utilization, including mortality and caregiving burden
Treatment Details
Interventions
- Direct Transfer to Angiography Suite (DTAS)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Santiago Ortega Gutierrez
Lead Sponsor
Patient-Centered Outcomes Research Institute
Collaborator