Treatment for Cerebrovascular Stroke

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Casa Colina Hospital and Centers for Healthcare, Pomona, CA
Cerebrovascular Stroke+1 More
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a training program can improve arm function in people with stroke.

See full description

Eligible Conditions

  • Cerebrovascular Stroke

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 3 primary outcomes and 3 secondary outcomes in patients with Cerebrovascular Stroke. Measurement will happen over the course of Change from baseline to 1 month post-intervention.

Month 1
Change in Action Research Arm Test (ARAT)
Change in Box and Block test score (BBT)
Change in Upper Extremity Fugl-Meyer (UEFM)
Change in arm reaching movement time.
Change in movement smoothness
Change in speed Accuracy Trade-off

Trial Safety

Safety Estimate

1 of 3

Trial Design

1 Treatment Group

Speed-biased complex motor skill training
1 of 1
Active Control

This trial requires 40 total participants across 1 different treatment group

This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Speed-biased complex motor skill training
Behavioral
Participants will perform 400 complex movements per day over 4 days over a one-week period. The task requires participants to navigate their hand through a "track" projected on the surface of a table with a width of 5cm. Participants receive adaptive score based on their movement time. .

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: change from baseline to 1 month post-intervention
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly change from baseline to 1 month post-intervention for reporting.

Who is running the study

Principal Investigator
C. W.
Prof. Carolee Winstein, Professor, Biokinesiology and Physical Therapy
University of Southern California

Closest Location

Casa Colina Hospital and Centers for Healthcare - Pomona, CA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
At least 6 months following an ischemic supratentorial stroke
At least 21 years of age
Exhibit residual capability to move the paretic UE (Upper Extremity Fugl- Meyer motor score >20/66)
Able to follow a 2-step command (8th item on the MMSE test)
Able to perform an unassisted arm reach movement of 25 cm ahead of the body within 5 seconds with trunk restraint
Exhibit no greater than mild/moderate spasticity as assessed with a Modified Ashworth Score < 3

Patient Q&A Section

What are the signs of stroke?

"Atypical presentation of major ischemic stroke can alert clinicians to the need for closer examination, especially if they recognize signs of a stroke in their patients." - Anonymous Online Contributor

Unverified Answer

How many people get stroke a year in the United States?

"An estimated 2.6 million patients in the United States are hospitalized for a stroke (3.5 per 100,000), and 600,000 die from the condition within a year of admission. On average, 11,700 strokes in the U.S. are fatal each year." - Anonymous Online Contributor

Unverified Answer

What is stroke?

"Stroke is a deadly and disabling condition. It is the sixth leading cause of disability worldwide. More than half of all strokes in the world occur in the developing countries where about 80% of the global stroke burden is concentrated." - Anonymous Online Contributor

Unverified Answer

What causes stroke?

"Stroke is not only a stroke, but also a catastrophic and very painful event for both patient and family. Prevention and treatment are essential to reduce the incidence and morbidity of stroke. The risk of stroke is low following a transient ischemic attack due to atrial fibrillation, but is relatively high following a transient ischemic attack due to carotid artery occlusion. The risk of stroke can be reduced by maintaining a healthy weight and blood pressure. The risk of stroke can be very high in patients who have heart attack, stroke or cardiac arrest. Factors that increase the risk of stroke include smoking (excluding smoking while the brain is undergoing ischemic recovery), hypertension, diabetes and obesity." - Anonymous Online Contributor

Unverified Answer

What are common treatments for stroke?

"There is a paucity of evidence-based practices for stroke, especially for those that could provide preventive care. In the U.S., there has been an increase in research in recent years toward developing an evidence-based system of stroke care, with particular attention to preventive care. The evidence-based approach has been suggested as the optimal strategy for stroke prevention." - Anonymous Online Contributor

Unverified Answer

Can stroke be cured?

"Though most patients with acute stroke are treated within 48 hours of symptom onset, some do not regain full neurological function and can still have severe disability at 3 months. A randomized trial into the question of whether early stroke intervention would enhance functional recovery following acute stroke would be challenging to conduct, but may be required if recent studies indicating a lack of benefit persist." - Anonymous Online Contributor

Unverified Answer

How serious can stroke be?

"The first symptoms of a stroke can appear minutes after the onset of the accident. For a patient with minor stroke the prognosis is good but very specific and careful clinical check periodically is needed to prevent recursion in severity. A patient with stroke of mild degree and no risk factors should be evaluated in less than 12-24h; the patient is discharged. One day after the onset of the major symptoms, CT or MRI scans and CT-PET are performed to the best in terms of diagnosis and prognosis but a full neurological examination to rule out cerebral blood flow deficit by transcranial Doppler and transcranial color Doppler is also needed in high risk patients, so that some risk factors can be detected and treated." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving treatment?

"A treatment trial with more rigorous protocols could greatly increase the likelihood of finding a beneficial agent. Until this happens, it would be prudent to report any trials without conclusive evidence and to publish them in an obscure journal which might have delayed treatment if the results became evident. To maximize the potential for a beneficial outcome, researchers should employ appropriate clinical trials techniques and consider all potential treatments before conducting placebo-controlled trials. Results from a recent paper demonstrate the problem of selective reporting of positive results." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of stroke?

"High-risk occupations and CVD risk factors, such as smoking, obesity and hypertension, are also involved in the triggering of ischemic strokes. Smoking and diabetes increase the risk of ischemic strokes, and they may promote atherosclerosis via platelets and lipids. These risk factors are linked to CVD, which is the primary cause of ischemic stroke." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in treatment for therapeutic use?

"The clinical trials were all negative from all four drugs in preventing new strokes. The studies showed that only niflumic acid decreased the risk of death with high quality evidence, and could reduce the risk of death and stroke by 53 and 47%, respectively. Aspirin and clopidogrel do not decrease the risk of death or stroke. They can reduce the risk slightly, by 16% and 22%, respectively. Aspirin and clopidogrel significantly decrease the risk of death from any cause by 36 and 41%, respectively." - Anonymous Online Contributor

Unverified Answer

What is the latest research for stroke?

"The advances in stroke management come in the realms of technology, the pharmaceutical treatment, and a good understanding of the mechanism and consequences of stroke, and the risk factors, management, and prevention of strokes." - Anonymous Online Contributor

Unverified Answer

Does stroke run in families?

"We found an excess of stroke admissions in families with previous strokes. This may reflect a genetic component to strokes. However, in contrast to other conditions, such as hypertension, diabetes, or coronary disease, no association between stroke, hypertension, Type 1 diabetes, or coronary disease, and previous cerebrovascular disease was identified." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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