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Cardiovascular training for Stroke

N/A

Waitlist Available

Led By Marc Roig, PhD

Research Sponsored by McGill University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 8 weeks

Awards & highlights

Study Summary

This trial will investigate whether cardiovascular exercise can help stroke patients in early recovery, and whether this effect is different for people with different genetic makeup.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 8 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~8 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Cortico-spinal excitability

Intra-cortical facilitation

Intra-cortical inhibition

Secondary outcome measures

Brain-derived neurotrophic factor

Cardiorespiratory fitness

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Cardiovascular trainingExperimental Treatment1 Intervention

Cardiovascular training will comprise 4 weeks of moderate-to-vigorous continuous training followed by 4 weeks of progressive high-intensity interval training (HIIT) performed on recumbent steppers. This intervention will be performed in addition to the conventional standard therapy sessions. We will start with very moderate intensities and prepare participants for higher intensities. Introducing HIIT will allow us to use higher intensities over short bursts of exercise interspersed with periods of active rest. HIIT is more effective than continuous training to increase BDNF and we have shown that even a single bout of HIIT reduces interhemispheric imbalances in excitability and improves motor learning in chronic stroke.

Group II: Standard TherapyActive Control1 Intervention

Will comprise 8 weeks of the control protocol that includes regular sessions of physiotherapy, occupational therapy, and speech therapy.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Cardiovascular training

2018

N/A

~70

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Find a Location

Who is running the clinical trial?

McGill UniversityLead Sponsor

395 Previous Clinical Trials

999,307 Total Patients Enrolled

16 Trials studying Stroke

3,214 Patients Enrolled for Stroke

Marc Roig, PhDPrincipal InvestigatorMcGill University

1 Previous Clinical Trials

80 Total Patients Enrolled

1 Trials studying Stroke

80 Patients Enrolled for Stroke

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available slots left in this research project?

"As per information hosted on clinicaltrials.gov, this medical trial is presently recruiting participants. This study was first unveiled to the public on June 20th 2018 and its details were most recently modified on November 17th 2022."

Answered by AI

Is there an age cap for prospective participants of this trial?

"This clinical trial's eligibility requirements stipulate that applicants must be between 40 and 80 years of age. Conversely, there are 37 trials for minors aged under 18 and 1006 studies specifically designed for individuals over the age of 65."

Answered by AI

Who is eligible to partake in this experiment?

"This research endeavour is looking to enrol 50 stroke sufferers aged 40-80. Eligibility demands that they have had an initial ischemic (brain or subcortical) stroke, with evidence of motor-evoked potentials from the impinged hemisphere, and no major neurological issues apart from their condition itself. Moreover, all participants must demonstrate sufficient cognitive function and communication skills necessary for safe protocol completion."

Answered by AI

What is the enrollment cap for this clinical investigation?

"Affirmative, according to clinicaltrials.gov this medical research is actively seeking volunteers. The study was initially published on June 20th 2018 and modified on November 17th 2022; 50 participants are sought from a single centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Exercise and Genotype in Sub-acute Stroke

Marc Roig 2018. "Exercise and Genotype in Sub-acute Stroke". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05076747.