Rescue Thrombectomy for Stroke
(2BE3 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
In stroke patients, mechanical thrombectomy is now the standard of care when the stroke is due to large proximal cerebral vessel occlusion. The purpose of the 2BE3 trial is to test whether adjunct rescue treatment of persisting distal occlusions after successful proximal recanalization of the large vessel occlusion can be proposed as an additional intervention to restore reperfusion of affected stroke tissue and improve clinical outcomes.The rescue therapies will be either mechanical (small stent retrievers and/or small aspiration catheters) or pharmacological (infusion of intra-arterial thrombolytics).Patients will be randomized to conservative management (mechanical thrombectomy with or without IV thrombolytics of large proximal vessels) or rescue therapy (mechanical or pharmacological interventions in distal vessels in addition to conservative management). Each patient will be followed for 3 months post-intervention.The data collected will be clinical assessments and angiographic imaging to evaluate the reperfusion state.
Do I need to stop my current medications for the trial?
The trial does not specify if you need to stop taking your current medications, but it excludes those who have taken certain blood thinners like heparin or direct oral anticoagulants in the previous 48 hours. It's best to discuss your current medications with the trial team.
Is mechanical thrombectomy generally safe for humans?
How is mechanical thrombectomy unique compared to other stroke treatments?
Mechanical thrombectomy is unique because it physically removes the blood clot from a large vessel in the brain, which can significantly improve outcomes for stroke patients. Unlike other treatments that may use medication to dissolve clots, this procedure directly retrieves the clot, making it effective even when medication alone is insufficient.678910
What data supports the effectiveness of the treatment Rescue Thrombectomy for Stroke?
Who Is on the Research Team?
Daniela Iancu, MD
Principal Investigator
Centre hospitalier de l'Université de Montréal (CHUM)
Are You a Good Fit for This Trial?
This trial is for stroke patients who've had a clot removed from a large brain artery but still have smaller blockages. They must be candidates for thrombectomy, not at high risk of bleeding or poor prognosis due to other illnesses, and not on certain blood thinners.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either conservative management or rescue therapy for distal occlusions
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Mechanical thrombectomy in proximal large vessels
- Rescue mechanical thrombectomy in distal vessels
Find a Clinic Near You
Who Is Running the Clinical Trial?
Centre hospitalier de l'Université de Montréal (CHUM)
Lead Sponsor