High Intensity Interval Training for Stroke

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Toronto Rehabilitation Institute - Rumsey Centre, Toronto, Canada
Stroke
High Intensity Interval Training - Behavioral
Eligibility
Any Age
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a type of exercise called high-intensity interval training (HIIT) is more effective than moderate intensity continuous exercise (MICE) in improving walking function and cardiovascular fitness in stroke patients.

See full description

Treatment Effectiveness

Study Objectives

This trial is evaluating whether High Intensity Interval Training will improve 2 primary outcomes and 8 secondary outcomes in patients with Stroke. Measurement will happen over the course of 0 to 24 weeks.

0 to 24 weeks
Adherence
Adverse Events
0, 24 weeks
Change in Cardiovascular fitness - Peak oxygen uptake (VO2peak)
Change in Dual task gait velocity
Change in Six Minute Walk Test
Neuropsychological Test Battery (change over time)
Week 24
Muscle Oxygenation
24 weeks
Patient satisfaction
Week 24
Change in Brain Blood Flow response to exercise
VO2 during HIT and MICE

Trial Safety

Trial Design

2 Treatment Groups

Moderate Intensity Exercise
1 of 2
High Intensity Training
1 of 2
Active Control
Experimental Treatment

This trial requires 104 total participants across 2 different treatment groups

This trial involves 2 different treatments. High Intensity Interval Training is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

High Intensity Training
Behavioral
High Intensity Interval Training patients will attend the centre 3 times/week for 24 weeks. All subjects will participate in MICE aerobic training 5 days/week in the first four weeks of the study to provide a foundation of fitness and endurance for the safe prescription of HIIT. Subsequently, the HIIT group will replace 3 MICE training days with 3 HIIT. HIIT sessions will include two 20 minute protocols; 30:60 second work:active rest ratio, and 120:180 second work:active rest ratio on a treadmill with a harness for fall protection. In addition to supervised exercise training (3 times/week), MICE will be conducted 2 times/week in the home/community, which has been shown to be both safe and effective
Moderate Intensity Exercise
Behavioral
Moderate Intensity Continuous Exercise patients will attend the centre 3 times/week for 24 weeks. Participants will be progressed to 30 to 60 minutes of continuous exercise at the heart rate that occurred at the anaerobic threshold on the exercise test. Participants will exercise on a treadmill with a harness ofr fall protection. In addition to supervised exercise training (3 times/week), MICE will be conducted 2 times/week in the home/community by both cohorts.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
High Intensity Interval Training
2013
N/A
~1150

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 0, 8 weeks, 12 weeks, 24 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 0, 8 weeks, 12 weeks, 24 weeks for reporting.

Who is running the study

Principal Investigator
S. M.
Susan Marzolini, Principle Investigator
University Health Network, Toronto

Closest Location

Toronto Rehabilitation Institute - Rumsey Centre - Toronto, Canada

Eligibility Criteria

This trial is for patients born any sex of any age. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
The clinical diagnosis of a stroke is made by determining whether the individual has suffered a hemorrhagic stroke or an ischemic stroke. show original
The person has the ability to walk without severe limitations due to pain show original
People who have had a stroke and have a motor impairment score of less than 7 on the Chedoke-McMaster Stroke Assessment scale of the leg or foot, or who have a hemiparetic gait pattern, are encouraged to live in the community show original
There are no orthopedic issues that may be aggravated by HIT. show original
ability to provide informed consent
There was no severe communicative aphasia or comprehensive aphasia as noted in clinical reports or referral form. show original

Patient Q&A Section

What is stroke?

"Stroke affects between 1 and 4 million Americans each year and is one of the leading causes of disability or death in the United States. It causes more than a half million injuries or long-term disability each year or a cost of between $16 billion and $22 billion to treat. The incidence of stroke is rising, with an average annual rate of 2.3% for the period 1975–95. Men and women equally need urgent treatment. People over 55 are at risk of having a stroke and they have a higher mortality. Strokes are a risk factor for heart disease and death, even after controlling for risk factors in men and women." - Anonymous Online Contributor

Unverified Answer

What causes stroke?

"Stroke is due to stroke mechanisms involving both vessel wall disruption and embolism. Blood vessel disease is the dominant mechanism in a majority of individuals. Atherosclerosis, hypertension, atrial fibrillation, and diabetes are all independent risk factors for stroke." - Anonymous Online Contributor

Unverified Answer

Can stroke be cured?

"Almost 50 % of patients with an ischemic stroke have symptoms that persist after an average of 30 days, although in a majority of the cases it disappears. In the light of those data and the absence of any evidence that a cure can be achieved, the use of ischemia as a means to detect recurrent stroke and evaluate therapies against future strokes is not recommended." - Anonymous Online Contributor

Unverified Answer

What are the signs of stroke?

"As of 2016, there were no national guidelines for emergency healthcare providers to make the diagnosis of mild or moderate cases of stroke. Stroke has not been routinely considered when there is low-grade fever, and clinical indicators when looking for acute coronary syndromes, to assess the appropriateness of cardioembolic disease in people with stroke. The American Heart Association's 2015 guideline “AHA Heart Rhythm Society Lifelong and Transmittable Stroke Program: What Everyone Needs to Know” provides great information about clinical findings, diagnostic approaches, and treatment options for stroke." - Anonymous Online Contributor

Unverified Answer

How many people get stroke a year in the United States?

"The approximate number of new cases of stroke is 1.5 million per year. There is an annual risk of stroke of around 7%. These cases occur chiefly in the elderly.\n" - Anonymous Online Contributor

Unverified Answer

What are common treatments for stroke?

"Treatment for stroke is highly reliant on the type and severity of the stroke, as well as specific medical and occupational therapy techniques. Treatment typically starts with thrombolysis, however, there is no standard for treatment as some patients present without the signs and symptoms of stroke. Stroke may also be treated through the use of angioplasty and stents, embolisation, or decompression of the brain.\n" - Anonymous Online Contributor

Unverified Answer

Does high intensity interval training improve quality of life for those with stroke?

"In a recent study, findings is the first to evaluate high intensity interval training using quality of life measures. Findings suggest that participants in the intervention group reported a greater improvement in quality of life compared to the control group at post intervention and follow up periods. High intensity interval training is suggested for people with stroke to enhance the quality live of these individuals." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of high intensity interval training?

"These side effects are very common and should be taken into consideration when choosing HIIT training. They include heat exhaustion, musculoskeletal discomfort, lack of sleep, and gastrointestinal discomfort." - Anonymous Online Contributor

Unverified Answer

How does high intensity interval training work?

"HIIT is similar to other forms of ET when it comes to training volume overload and improved VO2 peak. HIIT is not comparable to ET with regards to increased T2 and increased power. Additionally, HIIT is not superior to ET when it comes to VO2 peak improvements." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in high intensity interval training for therapeutic use?

"Based on recent literature and our experience, we prefer the term 'interval training' for our work because we believe that 'high-intensity interval training' is ambiguous and could be misinterpreted." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets stroke?

"The average age at onset of stroke is 70 years, with the oldest being aged 83. The average age at death is 74. The average age of death in women is three years earlier than in men." - Anonymous Online Contributor

Unverified Answer

What is high intensity interval training?

"HIIT is a dynamic training modality that allows a gradual increase in volume over time without negatively impacting muscle function and body composition. HIIT can be applied in a variety of populations with many different training programs. A HIIT protocol should include intense, short, high-volume exercise sessions interspersed with at least 60 seconds of rest or low intensity exercise." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
See if you qualify for this trial
Get access to this novel treatment for Stroke by sharing your contact details with the study coordinator.