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High Intensity Interval Training for Stroke (HIIT-Stroke Trial)

N/A

Waitlist Available

Led By Susan Marzolini, PhD

Research Sponsored by University Health Network, Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 0, 8 weeks, 12 weeks, 24 weeks

Awards & highlights

HIIT-Stroke Trial Summary

This trial will compare the effects of two different types of exercise on walking ability and cardiovascular fitness in stroke patients. HIIT is hypothesized to result in greater benefit than MICE.

HIIT-Stroke Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 0, 8 weeks, 12 weeks, 24 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~0, 8 weeks, 12 weeks, 24 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 0, 8 weeks, 12 weeks, 24 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Cardiovascular fitness - Peak oxygen uptake (VO2peak)

Change in Six Minute Walk Test

Secondary outcome measures

Adherence

Adverse Events

Change in Brain Blood Flow response to exercise

+5 more

HIIT-Stroke Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: High Intensity TrainingExperimental Treatment1 Intervention

High Intensity Interval Training patients will attend the centre 3 times/week for 24 weeks. All subjects will participate in MICE aerobic training 5 days/week in the first four weeks of the study to provide a foundation of fitness and endurance for the safe prescription of HIIT. Subsequently, the HIIT group will replace 3 MICE training days with 3 HIIT. HIIT sessions will include two 20 minute protocols; 30:60 second work:active rest ratio, and 120:180 second work:active rest ratio on a treadmill with a harness for fall protection. In addition to supervised exercise training (3 times/week), MICE will be conducted 2 times/week in the home/community, which has been shown to be both safe and effective

Group II: Moderate Intensity ExerciseActive Control1 Intervention

Moderate Intensity Continuous Exercise patients will attend the centre 3 times/week for 24 weeks. Participants will be progressed to 30 to 60 minutes of continuous exercise at the heart rate that occurred at the anaerobic threshold on the exercise test. Participants will exercise on a treadmill with a harness ofr fall protection. In addition to supervised exercise training (3 times/week), MICE will be conducted 2 times/week in the home/community by both cohorts.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

High Intensity Interval Training

2013

N/A

~1190

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Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor

1,468 Previous Clinical Trials

484,443 Total Patients Enrolled

24 Trials studying Stroke

5,524 Patients Enrolled for Stroke

Susan Marzolini, PhDPrincipal InvestigatorToronto Rehabilitaiton Institute

Paul Oh, MDStudy DirectorToronto Rehabilitation Institute

5 Previous Clinical Trials

392 Total Patients Enrolled

1 Trials studying Stroke

43 Patients Enrolled for Stroke

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are accepted into this research experiment?

"Affirmative. The details posted on clinicaltrials.gov indicate that this medical trial is actively recruiting participants. It was first published in March of 2017 and modified most recently on January 14th 2020, with the need for 104 patients from a single site being specified."

Answered by AI

Are there any vacancies for participation in this experiment?

"Affirmative, the material on clinicaltrials.gov reveals that this medical experiment is actively searching for participants. It was initially posted on March 1st 2017 and amended most recently on January 14th 2020 with a need to enlist 104 patients at one single site."

Answered by AI

What are the core goals of this clinical examination?

"The primary aim of this trial, to be measured after 0 and 24 weeks, is the alteration in cardiovascular fitness as calculated by peak oxygen uptake (VO2peak). Secondary objectives entail a determination of patients' ability to reach intensity thresholds during HIT training and MICE using an ambulatory oxygen monitor; ventilatory values assessed with CORTEX Biophysik MetaMax®3X portable gas analysis every 10 seconds; changes over time via two executive function measures for selective attention and inhibition processes alongside speed-of-processing tests such as Trails A/B, DKEFS verbal fluency assessments, and Weschsler digit symbol coding."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

High Intensity Interval Training for People With Stroke Deficits

Susan Marzolini 2017. "High Intensity Interval Training for People With Stroke Deficits". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03006731.