CLINICAL TRIAL

Breathing Exercise for Stroke

Recruiting · 18+ · All Sexes · Minneapolis, MN

Development of Upper Limb Motor Scale to Measure Quality of Movement and Body Awareness in Stroke

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About the trial for Stroke

Treatment Groups

This trial involves 2 different treatments. Breathing Exercise is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Breathing Exercise
OTHER
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Females and males ages 18-99 years of age
People with stroke who are medically stable with one or more ischemic or hemorrhagic stroke(s)
left or right hemiplegia
willing and able to attend a one-time behavioral testing session
willing and able to sign consent to participate
able to hear, read and comprehend instructions given during the study
English speaking (or willing to work with a (student) translator)
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Baseline
Screening: ~3 weeks
Treatment: Varies
Reporting: Baseline
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Baseline.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Breathing Exercise will improve 2 primary outcomes and 3 secondary outcomes in patients with Stroke. Measurement will happen over the course of Baseline.

Reliability of a new scale for stroke: Awareness of Functional Tasks with Arm and Hand in Stroke (AFAS scale)
BASELINE
AFAS contains 13 items
BASELINE
Motor Evaluation Scale for Upper Extremity in Stroke Patients (MESUPES)
BASELINE
Scale using 0-58 for measurement, 0 being low and 58 being high. Assesses qualities of the arm and hand.
BASELINE
Validity a new motor scale for upper extremity Upper Limb Motor Scale in people with stroke (AFAS scale
BASELINE
Scale using 0-45 for measurement, 0 being low and 45 being high.
BASELINE
Revised Body Awareness Rating Scale (REVBA)
BASELINE
The Revised Body Awareness Rating Scales contains 12 items rated on a 4-point scale. Total scores range from 0 to 36 with lower scores indicating better body awareness.
BASELINE
Physical Body Experience Questionnaire (PBE)
BASELINE
The Physical Body Experience Questionnaire contains 12 items, rated on a 7-point Likert scale. Total scores range from 0 to 48 with lower scores indicated better physical body experience.
BASELINE

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is stroke?

Stroke is a disorder caused by an interruption of the arteries supplying the brain that result in brain damage, typically affecting one half of those affected. It occurs less commonly in men than in women and the elderly more than the young. It can be divided broadly into those that are caused by embolization of a clot in an artery that carries blood to the brain, and those that are caused by a disruption of a large blood vessel across the brain. Strokes can result in a range of severe clinical complications, including major disability and even death.

Anonymous Patient Answer

What causes stroke?

Stroke is the most common cause of brain dysfunction in adults. Though genetics may account for a small percentage of stroke patients, multiple factors can contribute to the cause of stroke, including high blood pressure, tobacco smoking, obesity, diabetes mellitus, and physical inactivity.

Anonymous Patient Answer

Can stroke be cured?

The number of new cases of stroke is rising rapidly, and the prognosis for the majority remains fairly poor. The treatment of stroke, especially early stroke treatment, should be intensified. This might save lives and minimise disability. Moreover, more rigorous trials need to be performed for a better understanding of the pathology and treatment efficacy of stroke.

Anonymous Patient Answer

What are the signs of stroke?

There are many common neurological signs that may be associated with an acute ischemic stroke. Among those, headaches are the most common sign, with focal (as opposed to focal and generalised) dizziness the most common complaint. Abnormal pupil size, deviation of gaze to the affected side and nystagmus could be the initial presentation. Other signs may be present, but are less common such as changes in sensory function, visual disturbances, unilateral weakness or numbness, and changes in consciousness.

Anonymous Patient Answer

How many people get stroke a year in the United States?

More than 1 in 5 individuals will have a transient ischemic attack or stroke in the next year. The estimates of stroke incidence vary widely by race, age, sex, and geographical region. For example, white males are estimated to account for 41% of stroke cases.

Anonymous Patient Answer

What are common treatments for stroke?

The findings of the survey suggest that therapies that can be administered at home are still being used by the majority of patients, while, to a lesser extent, home based therapies are also used. Results from a recent clinical trial reveal gaps in knowledge about the treatments used at home, information about the current use and the feasibility of implementing these different approaches.

Anonymous Patient Answer

Is breathing exercise safe for people?

Most people with chronic diseases of breathing will experience an elevation in arterial pressures while exercising. These increases often exceed 140 mmHg in untreated chronic disease and can be life-threatening. The risks of exercise training, in terms of cardiovascular outcomes are not yet well understood and in many cases there are no published data. It is believed that there will be a decline in performance due to lack of training, but these findings are not conclusive. It is imperative that exercise training (and also breathing exercises) is carried out with caution in those who are prescribed respiratory stimulant medication. Exercise is not recommended in those who have known or suspected cardiac instability, are using oral anti-coagulants or if there is a long-standing history of heart disease.

Anonymous Patient Answer

What is breathing exercise?

From our study we can conclude from our preliminary findings that most patients were able to perform a correct deep breathing exercise. We could not determine the impact of other types of exercise compared to deep breathing exercise, however, we noticed that many patients were able to tolerate those more strenuous activities. In terms of deep breathing exercise we recommend an initial training of half an hour for first week. This training will decrease the risk of hypoxia in the blood of patient.

Anonymous Patient Answer

What are the common side effects of breathing exercise?

To minimize side effects a correct ventilation can help the body to regulate its own levels of oxyhemoglobin, carboxyhemoglobin, and carbon dioxide in blood as well as reducing the body’s need for oxygen via improved ventilation. As a result, breathable air, and the oxygen in that air, is used more efficiently by muscles. Exercise should be limited if one is recovering from a stroke and also the intensity should be kept as low as possible in order to minimize the amount of oxygen needed. Exercise after brain injury may cause dizziness, blurred vision, muscle aches, and fatigue. These signs are normal and don’t require any medical attention.

Anonymous Patient Answer

What are the latest developments in breathing exercise for therapeutic use?

The concept of therapeutic use of breathing exercises is still evolving. There is still very limited evidence, and therefore most of these exercises should be considered to be 'unproven treatments'. It seems clear that breathing exercises help to improve chest pain, fatigue, and breathlessness in chronic obstructive pulmonary disease, but their use in any other type of musculoskeletal pain, or in cardiorespiratory training programs has not been demonstrated. Furthermore, most of these breathing exercises do not seem to affect blood pressure and, for this reason, they should only be prescribed when the relevant symptoms cannot be improved by medication, and they can be prescribed together with a drug if these symptoms remain after discontinuing the breathing exercises.

Anonymous Patient Answer

Who should consider clinical trials for stroke?

Results from a recent paper of this study, comparing clinician and patient-specific risk-benefit assessments for clinical trials of new treatment algorithms for symptomatic, first-ever acute stroke, strongly suggest that clinicians may overestimate risk-benefit assessments for patients and that patient-specific risk-benefit assessments provide a more accurate assessment.

Anonymous Patient Answer

What is the primary cause of stroke?

Primary causes of stroke were different between sexes, ages, races and races. Results from a recent paper also show that stroke was not caused by tobacco use.

Anonymous Patient Answer
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