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Cross-education + standard rehabilitation for Stroke (X-Ed-Stroke01 Trial)

N/A
Waitlist Available
Led By Jon Farthing, PhD
Research Sponsored by University of Saskatchewan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 26 weeks
Awards & highlights

X-Ed-Stroke01 Trial Summary

This trial will explore if cross-education, in addition to standard rehabilitation, leads to better recovery of upper limb function for stroke patients with hemiparesis. It will also examine the neural mechanisms associated with changes in motor function of the paretic arm post-stroke and use diffusion tensor imaging (DTI) tractography to measure connectivity and examine the extent to which white matter tract thickness correlates with preserved motor output in patients post-stroke.

X-Ed-Stroke01 Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 26 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 26 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Motor function scores as assessed using the Fugl-Meyer Assessment
Secondary outcome measures
grip and wrist strength
volume of motor cortex activation

X-Ed-Stroke01 Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: cross-education + standard rehabilitationExperimental Treatment1 Intervention
The cross-education group will engage in strength training of the non-paretic hand in addition to standard rehabilitation. Cross-education will be progressive in nature, beginning with 2 sets of 8 repetitions and increasing up to a maximum of 6 sets of 8 repetitions of maximal voluntary effort isometric handgrip contractions as tolerated. Grip training will be performed using standard grip trainers (Digi-Flex Grip trainers) to train both finger flexors and full hand and wrist isometric contractions. In addition, patients will perform controlled dynamic wrist flexion and extension training of the non-paretic hand using exercise tubing with the same prescription. Patients will be asked to complete exercises 3 times per week for 26 weeks, and to record adherence in a training log. An average of one session per week will be considered 'trained'.
Group II: standard rehabilitationActive Control1 Intervention
Standardized rehabilitation involves several strategies tailored to the patient and remains somewhat based on clinician preference. These therapies may involve functional electrical stimulation, neuro-facilitation, strengthening, range of motion (ROM), mirror therapy, and force-use therapy (e.g., CIMT). Patients engage in therapy 5 days per week as inpatients, and 2 days per week as outpatients with additional home exercises. Specific therapies for each patient will be tracked using a therapy log.

Find a Location

Who is running the clinical trial?

University of SaskatchewanLead Sponsor
251 Previous Clinical Trials
154,397 Total Patients Enrolled
2 Trials studying Stroke
42 Patients Enrolled for Stroke
Saskatchewan Health Research FoundationOTHER
32 Previous Clinical Trials
4,976 Total Patients Enrolled
Royal University Hospital FoundationOTHER
22 Previous Clinical Trials
7,535 Total Patients Enrolled

Frequently Asked Questions

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Recent research and studies
clinicaltrials.govStudy
Clinical Application of Cross-education During Stroke Rehabilitation
Jonathan Farthing 2016. "Clinical Application of Cross-education During Stroke Rehabilitation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02948725.
~2 spots leftby Apr 2025
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