This trial is evaluating whether Acute Intermittent Hypoxia (AIH) will improve 1 primary outcome and 8 secondary outcomes in patients with Stroke. Measurement will happen over the course of 6 days.
This trial requires 12 total participants across 1 different treatment group
This trial involves a single treatment. Acute Intermittent Hypoxia (AIH) is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"Around 700 deaths/year in the US are due to suffocation from an anoxic condition. The death rate is highest among those 45–64 years of age, with the average age of death being 63 years." - Anonymous Online Contributor
"In a recent study, findings demonstrates that anoxia and hypoxia induce an adaptive change in the central nervous system, which can alter its excitability-control of the body. The changes observed are discussed in relation to the etiology of the disease." - Anonymous Online Contributor
"As anoxia [causes] neurological, autonomic, and circulatory manifestations, it is important for doctors to [recognize and understand] these symptoms, such as [generalized tonic-clonic seizures] in [the absence of] a [diagnostic algorithm]." - Anonymous Online Contributor
"Anoxia is a common cause of death among hospital patients. In the United States, anoxia and oxygen toxicity are the ninth leading cause of death in emergency medicine." - Anonymous Online Contributor
"It's a new definition of anoxia, if the partial pressure of oxygen is less than 12 mm Hg for longer than 60 minutes. Because oxygen content may be measured in milligrams of oxygen, this makes anoxia a measurable number. A lower percentage of oxygen can be measured or measured with other techniques. Anoxia can be encountered under other pathological conditions such as hypothermia or acidosis. Also, anoxia is one of the key mechanisms in certain medical diagnoses such as cardiac arrest and asphyxia." - Anonymous Online Contributor
"With medical supervision and proper treatment, some survivors of acute cerebral hypoxia may become fully functional if given the proper rehabilitation regimen within 24 hours of a hypoxic episode. The best results in this area appear to be achieved if a multidisciplinary team is assembled and the treatment plan formulated by the specialists on call." - Anonymous Online Contributor
"The patient should be the one who will choose if participating in a clinical trial for anoxia. On the other hand, we should not recommend to a man who is not suffering from anoxia to participate to a clinical trial of anoxia." - Anonymous Online Contributor
"We hypothesize that Aih induced hypoxia and anoxia in the brain are in vivo toxic for central and peripheral nervous system tissues; they may cause severe damage to both the peripheral and the central nervous system. These side effects may be relevant to the negative effect of Aih on cognitive function and memory in anoxia." - Anonymous Online Contributor
"During anoxia the body will go through two phases of oxidative damage. The initial damage occurs on the cellular membrane, with oxidative modification of membrane components which can lead to cell death. During the two weeks phase the membrane will be damaged further, leading to cell death. This damage is more difficult to manage, as it increases with duration of anoxia and worsens with the number of cells dying. Although there is a high rate of anoxic injuries from anoxia; almost all fatal anoxic injuries occurred during a period of anoxia in which neither the patient nor the resuscitative team had noticed an issue. The severity of an anoxic injury is dependent on the duration and severity of the anoxia." - Anonymous Online Contributor
"Aih showed improvement in all of the secondary outcomes, confirming the hypothesis that Aih is more effective than a placebo in reversing cognitive impairment after 3 hours of severe hypoxia in healthy adults." - Anonymous Online Contributor
"In a recent study, findings of our study suggest that anoxia may not run in families. The study highlights the importance of familial testing when interpreting the results of studies of anoxia." - Anonymous Online Contributor
"The response of iox(h) to aih demonstrates the mechanism by which iox(h) induces apoptosis in HL-60(leukaemic) cells. Additionally, our data suggest that aih can induce iox(h) in HL-60(leukaemic) cells via downregulation of antioxidant defenses. Overall, our data indicates that aih may contribute to the development of anoxia-induced cell injury by decreasing antioxidant defenses. The beneficial effects of iox(h) against aih cannot be completely explained by its free radical scavenging activity alone, but likely also involves other mechanisms, such as inhibition of the pro-apoptotic pathway." - Anonymous Online Contributor