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Behavioural Intervention

Phenytoin + Cognitive Behavioral Therapy for Post-Traumatic Stress Disorder

N/A
Waitlist Available
Research Sponsored by VA Medical Center, Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Right-handed adult combat veterans over the age of 18
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

This trial is testing whether phenytoin or cognitive behavioral therapy can help to reduce impulsive aggression in people with PTSD.

Who is the study for?
This trial is for right-handed adult combat veterans over 18 with PTSD and a history of impulsive aggression, having committed at least three such acts in the past three months. Participants must be accompanied by a significant other who can report on their aggressive behavior.Check my eligibility
What is being tested?
The study aims to observe brain function changes after treating PTSD-related impulsive aggression using either phenytoin (a medication) or cognitive behavioral therapy (a type of psychotherapy).See study design
What are the potential side effects?
While not explicitly listed, side effects may include those commonly associated with phenytoin such as dizziness, coordination problems, and potential skin reactions; cognitive behavioral therapy typically does not have physical side effects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am a right-handed veteran over 18.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
change in impulsive aggressive acts measured by OAS-M
Secondary outcome measures
change in PTSD symptoms as measured by CAPS
change in depression symptoms as measured by BDI
change in regional brain activation as measured by FMRI

Find a Location

Who is running the clinical trial?

VA Medical Center, HoustonLead Sponsor
11 Previous Clinical Trials
1,067 Total Patients Enrolled
Michael E. DeBakey VA Medical CenterLead Sponsor
64 Previous Clinical Trials
15,776 Total Patients Enrolled
Dr. Thomas A. KentUNKNOWN

Media Library

Cognitive Behavioral Therapy (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT00333931 — N/A
Post-Traumatic Stress Disorder Research Study Groups:
Post-Traumatic Stress Disorder Clinical Trial 2023: Cognitive Behavioral Therapy Highlights & Side Effects. Trial Name: NCT00333931 — N/A
Cognitive Behavioral Therapy (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00333931 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research endeavor admitting participants older than 35 years?

"This clinical trial only allows applicants aged 18 to 65. There are 66 studies available for people beneath the age of majority, and 383 studies reserved for individuals above the elderly threshold."

Answered by AI

Is it feasible for me to join this experiment?

"This clinical trial is accepting 12 participants that are aged between 18 and 65 with a primary diagnosis of impulsive aggression. To be enrolled, applicants must meet the following prerequisites: they have to be right-handed adult combat veterans diagnosed with PTSD via Structured Clinical Interview (SCID-I), First, 2002 and Impulsive Aggression by meeting the criteria outlined in the Impulsive/Premeditated Aggression Scales (IPAS) as defined by Stanford et al 2003 based on interviews conducted with them and their significant other. Furthermore, those who wish to join this study need to furnish evidence of having committed at least three aggressive acts over"

Answered by AI

Is enrollment for this experiment open to the public at this time?

"The clinical trial, originally posted on June 1st 2006 and last revised on the following day is no longer recruiting. Nonetheless, there are currently 494 other medical studies that are still open to participants."

Answered by AI

Who else is applying?

What state do they live in?
Texas
How old are they?
18 - 65
What site did they apply to?
Veterans Affairs Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
~1 spots leftby Apr 2025