Personalized Brain Stimulation for Post-Traumatic Stress Disorder
What You Need to Know Before You Apply
What is the purpose of this trial?
This study is testing a personalized form of brain stimulation called PrTMS as a treatment for post-traumatic stress disorder (PTSD) in military service members and veterans. Unlike standard approaches, this treatment uses a simple brainwave test (EEG) to tailor the therapy to each individual. Participants will be randomly assigned to receive either active treatment or a comparison (sham) treatment over 6 weeks. Researchers will track changes in PTSD symptoms, mood, sleep, and overall well-being, including using wearable devices to measure things like sleep and heart rate. The goal is to see whether this personalized approach can provide greater and longer-lasting relief for individuals living with PTSD.
Who Is on the Research Team?
Sofia E Matta, MD
Principal Investigator
Massachusetts General Hospital
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive personalized, EEG-guided repetitive transcranial magnetic stimulation (PrTMS) or sham treatment administered 5 days per week for 6 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments over 6 months
What Are the Treatments Tested in This Trial?
Interventions
- Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS)
How Is the Trial Designed?
2
Treatment groups
Active Control
Placebo Group
Participants receive personalized, EEG-guided repetitive transcranial magnetic stimulation (PrTMS) administered 5 days per week for 6 weeks, with stimulation parameters individualized and adjusted over time based on serial sEEG and neurocognitive assessments.
Participants receive sham repetitive transcranial magnetic stimulation (rTMS) administered 5 days per week for 6 weeks using a sham coil that mimics the sound and sensation of active treatment without delivering a therapeutic magnetic field.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts General Hospital
Lead Sponsor
United States Air Force Research Laboratory
Collaborator
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