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Hydrocortisone + Prolonged Exposure Therapy for PTSD

N/A

Waitlist Available

Research Sponsored by Bronx VA Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up week 16

Awards & highlights

Study Summary

This trial is testing whether adding hydrocortisone to Prolonged Exposure therapy, an effective treatment for PTSD, will make the therapy more effective.

Who is the study for?

This trial is for veterans with chronic PTSD from deployment-related trauma, who are either unmedicated or on a stable psychotropic regimen for at least one month. They must have a minimum PTSD severity score and cannot have certain mental health conditions, severe TBI, recent substance abuse, unstable medical illnesses, or be pregnant.Check my eligibility

What is being tested?

The study tests if hydrocortisone can boost the effectiveness of Prolonged Exposure therapy in treating PTSD. It's based on findings that glucocorticoids help with learning and reducing traumatic memories. Participants will receive this combination to see if it helps more than therapy alone.See study design

What are the potential side effects?

Hydrocortisone may cause side effects like mood swings, weight gain, increased blood sugar levels (especially important for diabetics), insomnia, weakened immune response making you more prone to infections, and possible stomach ulcers.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ week 16

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~week 16

This trial's timeline: 3 weeks for screening, Varies for treatment, and week 16 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Post-Traumatic Stress Disorder

Secondary outcome measures

Biological measures associated with PTSD severity

Cognitive performance (learning and retention in an episodic memory task, attention and working memory)

Other measures of clinical outcome, psychological state and functioning

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Prolonged Exposure therapy with HydrocortisoneActive Control2 Interventions

Group II: Prolonged Exposure therapy with placeboPlacebo Group1 Intervention

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Lightfighter TrustUNKNOWN

Bronx VA Medical CenterLead Sponsor

20 Previous Clinical Trials

1,236 Total Patients Enrolled

Media Library

Prolonged Exposure therapy Clinical Trial Eligibility Overview. Trial Name: NCT01090518 — N/A

Post-Traumatic Stress Disorder Research Study Groups: Prolonged Exposure therapy with placebo, Prolonged Exposure therapy with Hydrocortisone

Post-Traumatic Stress Disorder Clinical Trial 2023: Prolonged Exposure therapy Highlights & Side Effects. Trial Name: NCT01090518 — N/A

Prolonged Exposure therapy 2023 Treatment Timeline for Medical Study. Trial Name: NCT01090518 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the upper capacity of individuals who can partake in this scientific exploration?

"This clinical trial has ceased patient recruitment, as the last update was posted on February 4th 2013. However, if you are seeking medical studies related to stress and traumatic disorders there 416 trials that are still recruiting participants and 60 studies involving Prolonged Exposure therapy with Hydrocortisone which have open slots for volunteers."

Answered by AI

What have prior studies revealed regarding the effectiveness of Prolonged Exposure therapy in conjunction with Hydrocortisone?

"Currently, there are 60 trials that examine the efficacy of Prolonged Exposure therapy with Hydrocortisone in operation. 20 out of these clinical studies have reached Phase 3 status. These medical experiments mainly take place around New york City; however, this treatment is being studied by 3054 facilities across the state."

Answered by AI

Is this research accessible to individuals below the age of fifty-five?

"The study requires volunteers aged between 18 and 89, however there are 76 trials for minors and 352 for seniors."

Answered by AI

In what contexts is Prolonged Exposure therapy with Hydrocortisone utilized?

"Prolonged Exposure therapy with Hydrocortisone has been shown to have a positive effect in managing ulcerative colitis as well as malignant neoplasms, varicella-zoster virus acute retinal necrosis, and crohn disease."

Answered by AI

Is there still opportunity for patients to participate in this clinical research?

"Per the data available on clinicaltrials.gov, this trial is no longer accepting applications and has not been recently updated since February 4th 2013 when it was first posted in 2010. However, there are still a plethora of other studies that require patient participation at the present moment."

Answered by AI

Am I qualified to participate in this medical trial?

"This experiment is seeking 50 volunteers who suffer from stress disorders and/or traumatic events. Prospective participants should be aged between 18 and 89 to qualify for enrollment."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Cortisol Augmentation of a Psychological Treatment in Warfighters With Post Traumatic Stress Disorder (PTSD)

Rachel Yehuda 2010. "Cortisol Augmentation of a Psychological Treatment in Warfighters With Post Traumatic Stress Disorder (PTSD)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01090518.

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