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Passive and Functional Electric Stimulation Cycling for Spinal Cord Injury

N/A

Waitlist Available

Led By Ann S Choe, Ph.D.

Research Sponsored by Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change from baseline fmri brain parcels at 2 weeks and 4 weeks after the start of intervention.

Awards & highlights

Study Summary

This trial will use a type of MRI that does not require performance of explicit motor tasks to detect early changes in the brain during intervention in spinal cord injury patients. The changes will be predictive of recovery.

Eligible Conditions

Spinal Cord Injury

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change from baseline isncsci scores at 2 weeks and 4 weeks after the start of intervention.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change from baseline isncsci scores at 2 weeks and 4 weeks after the start of intervention.

This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline isncsci scores at 2 weeks and 4 weeks after the start of intervention. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Spinal Cord Injuries

Resting state fMRI brain parcels

Resting state fMRI functional connectivity

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Functional Electric Stimulation cyclingActive Control1 Intervention

The Functional Electrical Stimulation (FES) cycling group will use RT300 ergometer (Restorative Therapies, Inc) with stimulation on.

Group II: Passive CyclingPlacebo Group1 Intervention

The passive cycling group will use the same RT300 ergometer with stimulation off.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.Lead Sponsor

88 Previous Clinical Trials

24,922 Total Patients Enrolled

National Institute of Neurological Disorders and Stroke (NINDS)NIH

1,340 Previous Clinical Trials

649,348 Total Patients Enrolled

Ann S Choe, Ph.D.Principal InvestigatorJohns Hopkins University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are receiving care as part of this research endeavor?

"Affirmative. According to clinicaltrials.gov, recruitment for this trial has been ongoing since August 1st 2019 and was last modified on July 18th 2022. The study requires the participation of 48 individuals across a single site."

Answered by AI

Is this investigation actively searching for participants?

"Affirmative, the data on clinicaltrials.gov verifies that this research endeavor is currently recruiting patients. It was initially posted in August of 2019 and last modified on July 18th 2022. The trial requires 48 participants at a single site to move forward with its goals."

Answered by AI

Can I join this medical study?

"This research trial is looking to enrol 48 individuals aged 18-65 with spinal cord injuries. Furthermore, applicants must have not used an FES ergometer in the past 4 weeks and be capable of following instructions as well as participating in regular follow up meetings. Additionally, those who meet ASIA classification A-D criteria and are deemed generally healthy may apply regardless of ethnicity or gender. Finally, this study only considers chronic SCI's that occurred more than 6 months prior to application submission."

Answered by AI

Does this medical experiment extend to participants of an advanced age?

"Eligible candidates for this trial must be aged 18 to 65. The database on clinicaltrials.gov contains 138 trials specifically designed for individuals younger than eighteen, and 735 trials tailored to participants over the age of sixty-five."

Answered by AI

Recent research and studies

Plos OneJournal

Reproducibility and Temporal Structure in Weekly Resting-state Fmri over a Period of 3.5 Years

Choe, Ann S., Craig K. Jones, Suresh E. Joel, John Muschelli, Visar Belegu, Brian S. Caffo, Martin A. Lindquist, Peter C. M. van Zijl, and James J. Pekar. 2015. “Reproducibility and Temporal Structure in Weekly Resting-state Fmri over a Period of 3.5 Years”. Edited by Daniel Margulies. Plos One. Public Library of Science (PLoS). doi:10.1371/journal.pone.0140134.

Frontiers in Human NeuroscienceJournal

Extensive Neurological Recovery from a Complete Spinal Cord Injury: A Case Report and Hypothesis on the Role of Cortical Plasticity

Choe, Ann S., Visar Belegu, Shoko Yoshida, Suresh Joel, Cristina L. Sadowsky, Seth A. Smith, Peter C. M. van Zijl, James J. Pekar, and John W. McDonald. 2013. “Extensive Neurological Recovery from a Complete Spinal Cord Injury: A Case Report and Hypothesis on the Role of Cortical Plasticity”. Frontiers in Human Neuroscience. Frontiers Media SA. doi:10.3389/fnhum.2013.00290.

Current Physical Medicine and Rehabilitation ReportsJournal

Advances in Spinal Functional Magnetic Resonance Imaging in the Healthy and Injured Spinal Cords

Choe, Ann S.. 2017. “Advances in Spinal Functional Magnetic Resonance Imaging in the Healthy and Injured Spinal Cords”. Current Physical Medicine and Rehabilitation Reports. Springer Science and Business Media LLC. doi:10.1007/s40141-017-0161-x.

NeuroImageJournal