Electrophysiology assessment - corticospinal tract for Spinal Cord Injuries

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Washington University, Saint Louis, MO
Spinal Cord Injuries
Electrophysiology assessment - corticospinal tract - Other
Eligibility
Any Age
All Sexes
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Study Summary

Spinal cord injury leads to long-lasting paralysis and impairment. Re-enabling movement of paralyzed areas is challenging and more information is needed about neurological recovery. The purpose of this study is to understand the contribution of individual neural tracts to movements facilitated by transcutaneous spinal cord stimulation (SCS).

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

2 Primary · 0 Secondary · Reporting Duration: 30 minutes before and 30 minutes into intervention

30 minutes before and 30 minutes into intervention
Changes in corticospinal tract excitability after training
Changes in reticulospinal tract excitability after training

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Reaction time evaluation during non-invasive spinal cord stimulation and leg mov...
1 of 2
Evaluation of motor evoked potentials during non-invasive spinal cord stimulatio...
1 of 2
Experimental Treatment

112 Total Participants · 2 Treatment Groups

Primary Treatment: Electrophysiology assessment - corticospinal tract · No Placebo Group · N/A

Reaction time evaluation during non-invasive spinal cord stimulation and leg movementsExperimental Group · 2 Interventions: Electrophysiology assessment - reticulospinal tract, Training with some stimulation · Intervention Types: Other, Other
Evaluation of motor evoked potentials during non-invasive spinal cord stimulation and leg movementsExperimental Group · 2 Interventions: Electrophysiology assessment - corticospinal tract, Training with some stimulation · Intervention Types: Other, Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 30 minutes before and 30 minutes into intervention
Closest Location: Washington University · Saint Louis, MO
Photo of university of washington 1Photo of university of washington 2Photo of university of washington 3
2008First Recorded Clinical Trial
8 TrialsResearching Spinal Cord Injuries
516 CompletedClinical Trials

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
1,772 Previous Clinical Trials
2,270,569 Total Patients Enrolled
19 Trials studying Spinal Cord Injuries
875 Patients Enrolled for Spinal Cord Injuries
Ismael Seanez, PhDPrincipal InvestigatorWashington University School of Medicine
1 Previous Clinical Trials
120 Total Patients Enrolled
1 Trials studying Spinal Cord Injuries
120 Patients Enrolled for Spinal Cord Injuries

Eligibility Criteria

Age Any Age · All Participants · 3 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.