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Acute Intermittent Hypoxia for Spinal Cord Injury

N/A

Waitlist Available

Led By Molly G Bright, DPhil

Research Sponsored by Northwestern University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up immediately before and ~ 1-hour after aih on the same day

Awards & highlights

Study Summary

This trial uses MRI to study changes in the brain and spinal cord before and after Intermittent Hypoxia therapy in patients with chronic cervical spinal cord injury.

Eligible Conditions

Spinal Cord Injury

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ immediately before and ~ 1-hour after aih on the same day

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~immediately before and ~ 1-hour after aih on the same day

This trial's timeline: 3 weeks for screening, Varies for treatment, and immediately before and ~ 1-hour after aih on the same day for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

BOLD fMRI activation in motor cortex during isometric hand grip tasks

BOLD fMRI vascular reactivity to a breath-hold task

Trial Design

1Treatment groups

Experimental Treatment

Group I: Acute Intermittent HypoxiaExperimental Treatment1 Intervention

Both healthy participants and those with spinal cord injury will receive the acute intermittent hypoxia (AIH) intervention. All participants are imaged pre- and post-AIH intervention, and thus serve as a self-comparison to observe the hypothesized improvement in bilateral hand strength.

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Who is running the clinical trial?

Northwestern UniversityLead Sponsor

1,585 Previous Clinical Trials

917,188 Total Patients Enrolled

Shirley Ryan AbilityLabOTHER

192 Previous Clinical Trials

14,842 Total Patients Enrolled

Molly G Bright, DPhilPrincipal InvestigatorNorthwestern University

1 Previous Clinical Trials

40 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any opportunities for individuals to join this research endeavor at the moment?

"Yes, according to clinicaltrials.gov the trial is actively seeking enrolment of 60 individuals from one site since it was first posted on May 20th 2019 and last edited on September 7th 2022."

Answered by AI

What are the requirements for enrolling in this clinical investigation?

"This study is open to 60 individuals aged 18-60 years with non-progressive spinal cord injuries that have occurred at least 6 months prior. Furthermore, applicants must be able to independently close and open one hand."

Answered by AI

Is this clinical trial open to participants of all ages, or is there an age limit?

"As per the inclusion criteria for this trial, qualified applicants must be between 18 and 60 years old. Alternatively, there are 74 clinical studies available to minors under 18 and 402 trials offered to seniors aged 65 or above."

Answered by AI

What is the upper limit of enrollees for this medical experiment?

"Affirmative, according to clinicaltrials.gov's records, this research study is currently enrolling volunteers. Initially posted on May 20th 2019 and recently updated on September 7th 2022, the trial needs 60 individuals across a single centre."

Answered by AI

Recent research and studies

Journal of NeuroscienceJournal

Spinal Synaptic Enhancement with Acute Intermittent Hypoxia Improves Respiratory Function After Chronic Cervical Spinal Cord Injury

Golder, F. J.. 2005. “Spinal Synaptic Enhancement with Acute Intermittent Hypoxia Improves Respiratory Function After Chronic Cervical Spinal Cord Injury”. Journal of Neuroscience. Society for Neuroscience. doi:10.1523/jneurosci.0148-05.2005.

NeurologyJournal

Effects of Acute Intermittent Hypoxia on Hand Use After Spinal Cord Trauma

Trumbower, Randy D., Heather B. Hayes, Gordon S. Mitchell, Steven L. Wolf, and Victoria A. Stahl. 2017. “Effects of Acute Intermittent Hypoxia on Hand Use After Spinal Cord Trauma”. Neurology. Ovid Technologies (Wolters Kluwer Health). doi:10.1212/wnl.0000000000004596.

Neurorehabilitation and Neural RepairJournal

Exposure to Acute Intermittent Hypoxia Augments Somatic Motor Function in Humans with Incomplete Spinal Cord Injury

Trumbower, Randy D., Arun Jayaraman, Gordon S. Mitchell, and William Z. Rymer. 2011. “Exposure to Acute Intermittent Hypoxia Augments Somatic Motor Function in Humans with Incomplete Spinal Cord Injury”. Neurorehabilitation and Neural Repair. SAGE Publications. doi:10.1177/1545968311412055.

NeurologyJournal