Study Summary
This trial uses MRI to study changes in the brain and spinal cord before and after Intermittent Hypoxia therapy in patients with chronic cervical spinal cord injury.
Eligible Conditions
- Spinal Cord Injury
Treatment Effectiveness
Effectiveness Progress
Study Objectives
2 Primary · 0 Secondary · Reporting Duration: Immediately before and ~ 1-hour after AIH on the same day
Immediately before and ~ 1-hour after AIH on the same day
BOLD fMRI activation in motor cortex during isometric hand grip tasks
BOLD fMRI vascular reactivity to a breath-hold task
Trial Safety
Safety Progress
Trial Design
1 Treatment Group
Acute Intermittent Hypoxia
1 of 1
Experimental Treatment
60 Total Participants · 1 Treatment Group
Primary Treatment: Acute Intermittent Hypoxia · No Placebo Group · N/A
Acute Intermittent Hypoxia
Other
Experimental Group · 1 Intervention: Acute Intermittent Hypoxia · Intervention Types: OtherTrial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: immediately before and ~ 1-hour after aih on the same day
Who is running the clinical trial?
Northwestern UniversityLead Sponsor
1,455 Previous Clinical Trials
789,634 Total Patients Enrolled
Shirley Ryan AbilityLabOTHER
173 Previous Clinical Trials
13,642 Total Patients Enrolled
Molly G Bright, DPhilPrincipal InvestigatorNorthwestern University
1 Previous Clinical Trials
23 Total Patients Enrolled
Eligibility Criteria
Age 18 - 60 · All Participants · 9 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:The text is saying that it is safe to be scanned by MRI.
I can speak English.
The ability to sign an informed consent form is an important part of being able to participate in a clinical trial
References
- Golder, F. J.. 2005. “Spinal Synaptic Enhancement with Acute Intermittent Hypoxia Improves Respiratory Function After Chronic Cervical Spinal Cord Injury”. Journal of Neuroscience. Society for Neuroscience. doi:10.1523/jneurosci.0148-05.2005.
- Trumbower, Randy D., Heather B. Hayes, Gordon S. Mitchell, Steven L. Wolf, and Victoria A. Stahl. 2017. “Effects of Acute Intermittent Hypoxia on Hand Use After Spinal Cord Trauma”. Neurology. Ovid Technologies (Wolters Kluwer Health). doi:10.1212/wnl.0000000000004596.
- Trumbower, Randy D., Arun Jayaraman, Gordon S. Mitchell, and William Z. Rymer. 2011. “Exposure to Acute Intermittent Hypoxia Augments Somatic Motor Function in Humans with Incomplete Spinal Cord Injury”. Neurorehabilitation and Neural Repair. SAGE Publications. doi:10.1177/1545968311412055.
- Hayes, H. B., A. Jayaraman, M. Herrmann, G. S. Mitchell, W. Z. Rymer, and R. D. Trumbower. 2013. “Daily Intermittent Hypoxia Enhances Walking After Chronic Spinal Cord Injury: A Randomized Trial”. Neurology. Ovid Technologies (Wolters Kluwer Health). doi:10.1212/01.wnl.0000437416.34298.43.
- Li, Yaqing, Ana M Lucas-Osma, Sophie Black, Mischa V Bandet, Marilee J Stephens, Romana Vavrek, Leo Sanelli, et al.. 2017. “Pericytes Impair Capillary Blood Flow and Motor Function After Chronic Spinal Cord Injury”. Nature Medicine. Springer Science and Business Media LLC. doi:10.1038/nm.4331.
- Golder FJ, Mitchell GS. Spinal synaptic enhancement with acute intermittent hypoxia improves respiratory function after chronic cervical spinal cord injury. J Neurosci. 2005 Mar 16;25(11):2925-32. doi: 10.1523/JNEUROSCI.0148-05.2005.
- Molly Bright 2019. "Measuring the Neurological Benefits of Intermittent Hypoxia Therapy With MRI". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05183113.
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Conditions
Cancer Related
Treatments