Research Network for Hereditary Spastic Paraplegia
(SP-CERN Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial focuses on hereditary spastic paraplegia (HSP), a condition that causes muscle stiffness and weakness, with the aim of better understanding and treating it. Researchers seek to study the progression of HSP, identify useful markers for tracking the disease, and find effective targets for new treatments. The trial seeks participants with specific types of HSP, known as SPG4 and SPG5A, confirmed by clinical and genetic tests. Participants will aid scientists in learning more about these conditions and testing potential new treatments. As a Phase 3 trial, this study represents the final step before FDA approval, offering participants the opportunity to contribute to the development of a potentially groundbreaking treatment.
Why are researchers excited about this trial?
Spastic paraplegia treatments are usually centered around physical therapy and medications like muscle relaxants to manage symptoms. However, researchers are excited about this trial because it aims to establish a Centers of Excellence Research Network. This network is unique as it allows for comprehensive collaboration among top researchers and clinicians, potentially leading to faster discoveries and more effective treatments. By creating a hub of shared knowledge and resources, the trial seeks to accelerate the development of innovative therapies and improve patient outcomes more efficiently than traditional approaches.
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Enrollment
Enrollment of 100 individuals with genetically-confirmed hereditary spastic paraplegia type 4 (SPG4) or hereditary spastic paraplegia type 5A (SPG5A) in the shared clinical database
Biobanking
Biobanking of blood samples from 100 individuals with SPG4 or SPG5A in a shared biobank
Follow-up
Participants are monitored for safety and effectiveness after enrollment and biobanking
What Are the Treatments Tested in This Trial?
Find a Clinic Near You
Who Is Running the Clinical Trial?
Boston Children's Hospital
Lead Sponsor
University of Washington
Collaborator
University of Iowa
Collaborator
University of Michigan
Collaborator
Columbia University
Collaborator
University of Miami
Collaborator
University of Texas Southwestern Medical Center
Collaborator
Children's Hospital Medical Center, Cincinnati
Collaborator
Baylor College of Medicine
Collaborator
Massachusetts General Hospital
Collaborator