Cigarette trial for Smoking Behaviors

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Pennsylvania, Philadelphia, PA
Smoking Behaviors
Cigarette trial - Other
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

Smokers believe that cigarettes with the "natural" or "organic" descriptors are less harmful than cigarettes without these descriptors, but we do not know if these beliefs are associated with how smokers interpret the experience of smoking a "natural" or "organic" cigarette, nor whether these beliefs are predictive of changes in smoking behavior or biological exposures. The primary goal of this study is to examine the relationship between exposure to "natural" or "organic" descriptors in cigarette advertising and smoking health risk expectancies, subjective effects, topography, and biological exposures. To accomplish this goal, we will enroll 250 adult daily cigarette smokers of Natural American Spirit (NAS) or non-NAS brands (125 in each group) in a within-subjects human laboratory study manipulating four expectancy conditions (own brand comparator, "natural" advertising, "organic" advertising, "conventional" advertising).

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

8 Primary · 0 Secondary · Reporting Duration: no sooner than 1 day after prior study visit and up to 3 months after first study visit.

Month 3
Difference in perceived chemical aftertaste to conventional condition - natural
Difference in perceived chemical aftertaste to conventional condition - organic
Difference in perceived chemical content relative to conventional condition - natural
Difference in perceived chemical content relative to conventional condition - organic
Difference in salivary aldehyde concentration relative to conventional condition - natural
Difference in salivary aldehyde concentration relative to conventional condition - organic
Difference in total puff volume relative to conventional condition - natural
Difference in total puff volume relative to conventional condition - organic

Trial Safety

Safety Progress

1 of 3

Trial Design

1 Treatment Group

Main arm
1 of 1
Experimental Treatment

250 Total Participants · 1 Treatment Group

Primary Treatment: Cigarette trial · No Placebo Group · N/A

Main arm
Other
Experimental Group · 1 Intervention: Cigarette trial · Intervention Types: Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: no sooner than 1 day after prior study visit and up to 3 months after first study visit.
Closest Location: University of Pennsylvania · Philadelphia, PA
Photo of Hospital of the University of Pennsylvania 1Photo of Hospital of the University of Pennsylvania 2Photo of University of Pennsylvania 3
2011First Recorded Clinical Trial
1 TrialsResearching Smoking Behaviors
1053 CompletedClinical Trials

Who is running the clinical trial?

University of Nevada, RenoLead Sponsor
24 Previous Clinical Trials
17,020 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 6 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are able to communicate in English.
You have a CO level of 10 or more at the Session 1 visit.
You are capable of providing written informed consent, which includes compliance with the requirements and restrictions listed in human participant protections.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.