Cigarette Smoke for Exposure to Pollution

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Zuckerberg San Francisco General Hospital, San Francisco, CA
Exposure to Pollution+3 More
Cigarette Smoke - Other
Eligibility
18 - 65
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether thirdhand smoke is as harmful as secondhand smoke.

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Eligible Conditions

  • Exposure to Pollution
  • Pollution; Exposure
  • Smoke Inhalation

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Cigarette Smoke will improve 1 primary outcome and 1 secondary outcome in patients with Exposure to Pollution. Measurement will happen over the course of Baseline (before exposure) 30 minutes (after 30 minutes exposure) and 3 hours..

Hour 3
Changes in flow-mediated dilation (FMD) of the brachial artery, caused by pollution exposures, measured by ultrasound
Day 5
Changes in trans-epidermal water loss caused by pollution exposures, comparing intact skin to tape-stripped skin

Trial Safety

Safety Progress

1 of 3

Trial Design

4 Treatment Groups

Inhalational Exposure to Secondhand Cigarette Smoke
1 of 4
Inhalational Exposure to Thirdhand Cigarette Smoke
1 of 4
Dermal Exposure to Thirdhand Cigarette Smoke
1 of 4
Clean Air Exposure
1 of 4
Active Control
Experimental Treatment
Non-Treatment Group

This trial requires 66 total participants across 4 different treatment groups

This trial involves 4 different treatments. Cigarette Smoke is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Dermal Exposure to Thirdhand Cigarette Smoke
Other
Participants will wear clothing that has been exposed to cigarette smoke, for 3 hours while breathing filtered, temperature and humidity controlled air.
Clean Air Exposure
Other
Participants will breathe filtered, temperature and humidity controlled air while wearing clean clothing for 3 hours.
Inhalational Exposure to Secondhand Cigarette Smoke
Other
Participants will breathe cigarette smoke aerosol that has been aged for 30 minutes, for 3 hours while wearing clean clothing.
Inhalational Exposure to Thirdhand Cigarette Smoke
Other
Participants will breathe cigarette smoke aerosol that has been aged for 22 hours, for 3 hours while wearing clean clothing.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, 30 minutes, 3 hours, 2 days, 5 days
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline, 30 minutes, 3 hours, 2 days, 5 days for reporting.

Closest Location

Zuckerberg San Francisco General Hospital - San Francisco, CA

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
The subject is in good health, as determined by a review of their medical history, blood pressure, and C-reactive protein, lipid, and blood sugar levels. show original
This person has not been exposed to second-hand smoke and has a low level of THC in their saliva. show original
If the flow mediated dilation is 4% or greater at the screening visit, the patient may be eligible for the study. show original

Patient Q&A Section

What causes smoke inhalation injury?

"Although the mechanism of injury incurred by smoke inhalation injury is still relatively unknown, there may be multiple pathways of injury. The extent of lung injury to a smoke inhaler is dependent upon the duration of use and breathing rate. Further research into the pathogenesis of inhalant injury could help develop more effective strategies for treatment, prevention, and risk reduction of injury." - Anonymous Online Contributor

Unverified Answer

How many people get smoke inhalation injury a year in the United States?

"There are approximately 10,000 deaths a year from traumatic smoke inhalation injuries at US emergency departments. While incidence of smoke inhalation injury is low, it remains highly fatal due to the rarity of smoking cessation. Prevention efforts may be more effective than treatment, as demonstrated by cessation rates after smoking cessation in patients who suffered a traumatic smoke inhalation injury." - Anonymous Online Contributor

Unverified Answer

What are common treatments for smoke inhalation injury?

"Many treatments may be needed for smoke inhalation to prevent secondary aspiration pneumonia. In some cases, ventilation and mechanical support should be provided throughout therapy." - Anonymous Online Contributor

Unverified Answer

What is smoke inhalation injury?

"Firemen and women have higher rates of smoke inhalation injury than the general American civilian population. Patients treated for smoke inhalation injury must be carefully evaluated for other possible causes of the acute respiratory distress syndrome." - Anonymous Online Contributor

Unverified Answer

Can smoke inhalation injury be cured?

"Smoke inhalation injury can be cured by reducing the number of smegma-producing, irritating, and allergenic particles produced by thermal combustion in an enclosed space of smegma to less than 80 particles cm(2)." - Anonymous Online Contributor

Unverified Answer

What are the signs of smoke inhalation injury?

"Smoke inhalation injury can result in several signs and symptoms. Inhalation can affect several parts of the body, for example, bronchi, lung parenchyma, upper respiratory tract, pleural membrane, airways and lungs." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving cigarette smoke?

"There may not be many other randomized clinical trials which study the effects of the smoke in the air on the health and well-being of patients with lung problems." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of smoke inhalation injury?

"In acute inhalation injury, mechanical ventilation and a lack of airway protection may be important causes of the injury, particularly for severe smoke inhalation injury." - Anonymous Online Contributor

Unverified Answer

Has cigarette smoke proven to be more effective than a placebo?

"There is still much debate about the role of smoking in acute lung injury, but there is a growing body of evidence which suggests that cigarette smoking produces more injury in the lungs of chronic smokers. A Cochrane review published in 2003 showed a small decrease to the risk of developing ALI or ARDS when smoked with a second cigarette, but there was not enough high quality evidence to tell the difference between a smoking pack per day and a smoking pack per day, or the effects of passive smoking. The study demonstrated no effect of smoking on the long term outcomes (death rate and disability rate). There seems to be some evidence to suggest that there may be an increase in risk of pneumonia in smokers." - Anonymous Online Contributor

Unverified Answer

How serious can smoke inhalation injury be?

"The most common cause of death in these patients was complications of the preexisting injury itself. A significant number of deaths were due to the second injury. It is prudent to ensure that patients undergoing cardiopulmonary bypass are exposed to clean air when the circuit is primed so that the circuit components do not become contaminated with smoke." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets smoke inhalation injury?

"The data obtained in this study suggest a relationship between age and smoke inhalation injury. Specifically, it indicates that age is positively associated with inhalation injuries in both genders." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating smoke inhalation injury?

"The following medical and surgical modalities have been used to stop lung edema and improve survival: pulmonary edema, lung-protective ventilation with a high FiO(2) to achieve a P(aCO) of 30 mmHg, bronchodilators, pleural drainage, hyperinflation, and tracheal intubation and surfactant therapy. However, the only treatments that have improved survival are those that have been widely used and supported by the majority of investigators, including hyperinflation and endotracheal intubation. A thorough review of current therapies and a critical appraisal of the evidence should be performed before initiating any clinical trials." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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