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Sleep Restriction and Light Exposure for Diabetes Management

N/A
Waitlist Available
Led By Charles A Czeisler, PhD, MD
Research Sponsored by Brigham and Women's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Able to spend 33 consecutive days/nights in the laboratory
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change between study day 15-16 vs. study day 32-33
Awards & highlights

Study Summary

This trial will compare how well the body processes sugar after a night of normal sleep vs. a night of sleep restriction with or without exposure to light at night.

Who is the study for?
This trial is for healthy adults who have regular sleep patterns, don't smoke, and can stay in a lab for 33 days. They must pass medical tests and have normal color vision. It's not for those with recent time zone travel, night shift work history, visual/hearing issues, drug/alcohol problems, or medication use.Check my eligibility
What is being tested?
The study examines how glucose metabolism is affected by sleep restriction alone versus sleep restriction combined with exposure to artificial light at night (ALAN). Participants will experience both conditions to see if ALAN worsens the impact of less sleep on blood sugar control.See study design
What are the potential side effects?
Since this trial involves lifestyle interventions rather than medications—like restricting sleep and exposure to artificial light—the side effects may include tiredness, stress from staying in the lab environment continuously for over a month, and potential temporary changes in mood or alertness.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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You can stay in the laboratory for 33 days and nights in a row.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change between study day 15-16 vs. study day 32-33
This trial's timeline: 3 weeks for screening, Varies for treatment, and change between study day 15-16 vs. study day 32-33 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Duration of Nocturnal Melatonin Secretion
Impairment of Glucose Tolerance
Impairment of Insulin Sensitivity
Secondary outcome measures
Triglycerides
Proteomic Profile

Trial Design

2Treatment groups
Experimental Treatment
Group I: Sleep Restriction without Extended Duration Artificial Light at Night (ALAN)Experimental Treatment1 Intervention
In the Sleep Restriction group without Extended Duration ALAN, the sleep episodes will be shortened to 5 hours as in the ALAN Condition (centered at the same time as the baseline sleep with bedtime 2.5 hours later and wake time 2.5 hours earlier), but the participant will remain sitting in bed in near darkness (< 1 lux) for the 2.5 hours before and after the 5-hour sleep episode, such that their exposure to room lighting and activity (14 hours/day) will remain similar to that in the Baseline condition.
Group II: Sleep Restriction with Extended Duration Artificial Light at Night (ALAN)Experimental Treatment2 Interventions
In the Sleep Restriction Group with Extended Duration Artificial Light At Night (ALAN) first, the sleep episodes will be shortened to 5 hours, centered at the same time as the baseline sleep (with bedtime 2.5 hours later and wake time 2.5 hours earlier).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Sleep Restriction
2016
N/A
~470

Find a Location

Who is running the clinical trial?

Brigham and Women's HospitalLead Sponsor
1,611 Previous Clinical Trials
11,470,499 Total Patients Enrolled
6 Trials studying Sleep Deprivation
4,005 Patients Enrolled for Sleep Deprivation
Charles A Czeisler, PhD, MDPrincipal InvestigatorBrigham and Women's Hospital
4 Previous Clinical Trials
98 Total Patients Enrolled
1 Trials studying Sleep Deprivation
25 Patients Enrolled for Sleep Deprivation

Media Library

Sleep Deprivation Research Study Groups: Sleep Restriction without Extended Duration Artificial Light at Night (ALAN), Sleep Restriction with Extended Duration Artificial Light at Night (ALAN)
Sleep Deprivation Clinical Trial 2023: Sleep Restriction Highlights & Side Effects. Trial Name: NCT04868539 — N/A
Sleep Restriction 2023 Treatment Timeline for Medical Study. Trial Name: NCT04868539 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research project allow for elderly participation?

"This particular trial is for young adults aged 20 through 40. Out of the 43 clinical trials focused on patients under 18, and the 196 trials for patients over 65, this one is the most specific."

Answered by AI

If I wanted to participate in this research, would I be able to?

"This research is only considering candidates that are 20-40 years old that currently suffer from sleep debt. Out of the 20 total people that will be accepted,"

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
Charles A. Czeisler, PhD, MD 2022. "Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04868539.
All > Sleep Deprivation
~6 spots leftby Mar 2025
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