This trial is evaluating whether Diphenylcyclopropenone (DPCP) will improve 1 primary outcome in patients with Skin Diseases. Measurement will happen over the course of 24 hours after application.
This trial requires 70 total participants across 4 different treatment groups
This trial involves 4 different treatments. Diphenylcyclopropenone (DPCP) is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase < 1 and are in the first stage of evaluation with people.
"Skin diseases are a diverse group of disorders, including most commonly viral and fungal infections and immune-related disorders. There are several specific skin diseases, as described below.\n" - Anonymous Online Contributor
"Topical solutions of steroid creams (using corticosterone or corticosteroid) are a common treatment for dermatitis, but topical gels and ointments are not commonly used. In the case of psora, many patients find great therapeutic benefit from antifungal ointments or tretinoin. In addition, systemic medications like benzoyl peroxide and retinoids like tazarotene are frequently used to reduce inflammation of the skin." - Anonymous Online Contributor
"Although many skin diseases have a cure rate of up to 90% with good treatment, the long-term outlook of patients suffering from these conditions is usually poor." - Anonymous Online Contributor
"Over 2.8 million US adults have at least one type of skin disease each year. Dermiatry affects one out of eight of all US adults." - Anonymous Online Contributor
"Skin diseases are a source of many symptoms that clinicians may observe during a clinical encounter. This article provides common signs of various skin diseases. More information on skin diseases is provided in the appropriate chapters." - Anonymous Online Contributor
"Immunological diseases are the most common cause of skin lesions. Skin cancers are usually caused by environmental factors, which include infection with Human papillomavirus, ultraviolet radiation, environmental tobacco smoke, occupation, and solar radiation"" - Anonymous Online Contributor
"DPCP may cause common side effects such as gastrointestinal complaints, sleep disturbances and headaches; it may also cause skin rash, photosensitivity, skin irritation, and reversible hearing impairment. Allergic reactions may be a significant and life-threatening side effect. The more sensitive subjects may experience seizures and other seizure-like symptoms. To evaluate the common side effects caused by DPCP and to prevent them, this article describes the pharmacological effects of DPCP and the pharmacokinetics profile. Copyright © 2016 John Wiley & Sons, Ltd." - Anonymous Online Contributor
"DPCP is a chemical that was discovered in 1937 and is synthesized with phenol, which is a common fragrance. DPCP is used to prepare other chemicals used to produce plasticizers and plastic. Diphenylcyclopropenone is also used as a synthetic intermediate for the production of vitamin A. It can also be a precursor to other drugs, including the fungicides (itraconazole), the antimetabolites (probenecid and fluocinolone acetonide, and flumethrin), and the immunomodulators (pimavanserin, flupentixin, and eplerenone)." - Anonymous Online Contributor
"Results of this study indicated that skin disorders such as vitiligo, and nail diseases were associated with an affected family member. Vitiligo was the most important skin disease, affecting the majority of the families included in our study." - Anonymous Online Contributor
"The term ‘used' in this report (used by patients) needs to be interpreted with care since the use of dpcp was not limited solely by symptoms of a (chronic, often uncontrolled) skin or connective tissue disorder but more likely included as a precaution to prevent the risk of further acute hypersensitivity reactions in that patient's family and/or subsequent patients. Dpcp use was largely dictated by patient wishes and expectations." - Anonymous Online Contributor
"The authors concluded that in Australia, the prevalence of skin diseases increases with age, the majority of which are age dependent: skin telangiectasias and lichen planus are the most common conditions in Australian dermatology clinics, while the most common skin diseases in children are eczema and perioral abscesses. In Australia, many paediatricians, dermatologists, general practitioners and specialists have a better insight of skin diseases, but have difficulty working and communicating with paediatricians. Data from a recent study indicate an urgent need to develop guidelines for diagnosing and treating pediatric skin conditions and an integrated pathway for referrals of paediatricians for dermatological assessment." - Anonymous Online Contributor
"Subjects reported a significant improvement at the end of three months on the self-reported quality of life questionnaire. DPCP did not produce a larger clinical improvement than placebo." - Anonymous Online Contributor