Fluconazole for Blood Pressure in Sedentary Lifestyle

Overseen By Molly K Courish, MSc, PhD(s)

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Université de Sherbrooke

Must not be taking: Antifungals, Heartburn meds, Antidepressants, others

Disqualifiers: Cardiovascular, Cerebrovascular, Respiratory, Metabolic, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

40 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how fluconazole affects blood pressure after sitting for two hours. Researchers aim to determine if prolonged sitting impacts certain arterial chemicals that help control blood pressure. The trial seeks healthy men and women without heart or metabolic diseases who are not taking medications that might affect blood pressure. Participants should also be non-smokers and not have extreme body weights. As an unphased trial, this study allows participants to contribute to important research on blood pressure regulation.

Will I have to stop taking my current medications?

Yes, you will need to stop taking certain medications to participate in this trial. You cannot be on medications for cardiovascular, metabolic, pulmonary, or neurological disorders, or regularly take specific drugs like sildenafil, certain antidepressants, antibiotics, statins, NSAIDs, or vitamin A supplements.

Is there any evidence suggesting that fluconazole is likely to be safe for humans?

Research shows that most people can take fluconazole without problems. This medicine often treats fungal infections. However, some safety points require attention. Studies indicate that fluconazole can affect heart rhythm, especially when combined with other medications. It might cause changes in heart rate or blood pressure for some individuals. Regularly checking blood pressure is advisable for those taking fluconazole, particularly if combined with other medications. Overall, while fluconazole is widely used and generally safe, monitoring heart health remains important during its use. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Fluconazole is unique because it is traditionally an antifungal medication, but researchers are exploring its potential to lower blood pressure in people with a sedentary lifestyle. Unlike standard blood pressure medications like ACE inhibitors or beta-blockers, which target the heart or blood vessels, fluconazole's mechanism of action might involve a different pathway, potentially offering a novel approach to managing blood pressure. Researchers are excited about this treatment because it could provide an alternative for individuals who do not respond well to existing therapies, and it represents a creative repurposing of an established drug.

What evidence suggests that fluconazole might be an effective treatment for blood pressure regulation in a sedentary lifestyle?

Research has shown that fluconazole might help control blood pressure. Studies have found that fluconazole affects blood pressure when used with other treatments. For instance, when combined with medications that relax blood vessels, fluconazole significantly lowered blood pressure. This trial will explore fluconazole's effects on blood pressure in individuals with a sedentary lifestyle, with separate treatment arms for males and females. Although more research is needed to fully understand its effects, these findings support the idea that fluconazole may help manage blood pressure, especially in situations where blood flow and pressure change, such as prolonged sitting. ^{2 6 7 8 9}

Who Is on the Research Team?

Myles W O'Brien, PhD

Principal Investigator

Université de Sherbrooke

Are You a Good Fit for This Trial?

This trial is for healthy Canadian males and females interested in understanding how prolonged sitting affects blood pressure. Participants should be generally sedentary but without cardiovascular conditions. Specific details on inclusion or exclusion criteria are not provided, so it's assumed that typical health screening will apply.

Inclusion Criteria

Not pregnant or breastfeeding

Not smoked nicotine or marijuana-containing products most days of the week within the past 6 months

I am between 18 and 65 years old.

Exclusion Criteria

I am currently taking medication for fungal infections, heartburn, depression, high cholesterol, pain/inflammation, or vitamin A supplements.

I am under 18 years old.

I am over 65 years old.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Baseline Assessment

Baseline blood flow and blood pressure responses are measured without sitting

1 day

1 visit (in-person)

Prolonged Sitting

Participants undergo a 2-hour bout of uninterrupted sitting to assess blood pressure regulation

2 hours

1 visit (in-person)

Post-Sitting Assessment

Blood pressure and heart rate are monitored for 24 hours after sitting using a wearable monitor

24 hours

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the intervention

1-2 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Fluconazole

Trial Overview

The study tests the role of EDHFs (chemicals affecting artery relaxation) on blood pressure after 2 hours of sitting. It compares baseline blood flow with post-sitting effects, using fluconazole to suppress EDHF release versus a placebo.

How Is the Trial Designed?

Group I: Males Experimental Treatment 2 Interventions

Group II: Females Experimental Treatment 2 Interventions

Who Is Running the Clinical Trial?

Université de Sherbrooke

Lead Sponsor

Trials

317

Recruited

79,300+

Dalhousie University

Collaborator

Trials

177

Recruited

402,000+

Citations

1.

clinicaltrials.gov

clinicaltrials.gov/study/NCT07396857

The Role of EDHFs on Blood Pressure Following a Bout ...

Participants will take 150mg of fluconazole, an EDHF inhibitor before and after a bout of prolonged sitting. What is the study measuring?

2.

ncbi.nlm.nih.gov

ncbi.nlm.nih.gov/sites/books/NBK606100/

Angiotensin Receptor Blockers and HCTZ Combination Drugs

Combining angiotensin receptor blockers (ARBs) and hydrochlorothiazide (HCTZ) effectively controls blood pressure due to synergistic action.

3.

researchgate.net

researchgate.net/publication/359735610_Effect_of_Fluconazole_on_Blood_Pressure_in_Patients_Treated_with_Dihydropyridine_Calcium_Channel_Blockers_A_Retrospective_Study

(PDF) Effect of Fluconazole on Blood Pressure in Patients ...

The combination of DCCBs and fluconazole was associated with a significant decrease in blood pressure on day 11–13 (p < 0.01).

4.

medcentral.com

medcentral.com/drugs/monograph/3780-390002/fluconazole-oral

Fluconazole: uses, dosing, warnings, adverse events, ...

Fluconazole appears to be at least as effective as and, in some cases, more effective than other antifungals used for initial treatment of esophageal Candida ...

5.

withpower.com

withpower.com/trial/phase-4-1-2022-a0d50

Fluconazole for Vascular Response in Healthy Subjects

This trial tests how fluconazole (Diflucan) affects blood flow in healthy individuals during muscle activity. Researchers aim to determine if a specific ...

6.

ncbi.nlm.nih.gov

ncbi.nlm.nih.gov/books/NBK537158/

Fluconazole - StatPearls - NCBI Bookshelf

Losartan: Fluconazole inhibits the metabolism of losartan. Blood pressure should be continuously monitored in patients receiving losartan.

7.

drugs.com

drugs.com/fluconazole.html

Fluconazole: Uses, Dosage, Side Effects, Warnings

Fluconazole can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart ...

8.

rxlist.com

rxlist.com/diflucan-drug.htm

Diflucan (Fluconazole): Side Effects, Uses, Dosage, ...

Patients should have their blood pressure monitored continuously. Lurasidone. Concomitant use of moderate inhibitors of CYP3A4 such as fluconazole may increase ...

9.

mayoclinic.org

mayoclinic.org/drugs-supplements/fluconazole-oral-route/description/drg-20071428

Fluconazole (oral route) - Side effects & dosage

Fluconazole is used to treat serious fungal or yeast infections, including vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal ...