60 Participants Needed

Positive Emotion Promotion for Anhedonia in Children

Age: < 18
Sex: Any
Trial Phase: Academic
Sponsor: Vanderbilt University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

If your child is taking medications for emotional or behavioral problems, they can continue only if they are on SSRIs or psychostimulants and have been on a stable dose for at least 6 weeks before joining the trial.

What data supports the effectiveness of the treatment Family Promoting Positive Emotions, Positive Family Therapy, Family-Based Positive Psychology Intervention, Psychoeducation, Psychoeducational therapy, Educational therapy for anhedonia in children?

Research suggests that enhancing positive emotions and experiences can help reduce anhedonia, which is a lack of interest or pleasure in activities. Treatments that focus on increasing positive affect, like positive psychology interventions, have shown promise in improving symptoms of anhedonia by targeting reward systems in the brain.12345

Is the Positive Emotion Promotion treatment safe for children?

The available research does not provide specific safety data for Positive Emotion Promotion treatments in children, but similar interventions targeting positive emotions and anhedonia in adults have not reported significant safety concerns.12346

How does the Family Promoting Positive Emotions treatment differ from other treatments for anhedonia in children?

This treatment is unique because it focuses on promoting positive emotions within the family setting, using techniques from positive psychology and psychoeducation to enhance the child's ability to experience pleasure, unlike other treatments that primarily aim to reduce negative emotions.12347

What is the purpose of this trial?

This trial will test the effects of a positive emotion-focused preventive intervention on reward responsiveness in children of mothers with histories of depression and anhedonia.

Eligibility Criteria

This trial is for children aged 8-12 with mothers who have experienced depression and anhedonia. Both must be fluent in English, live in the U.S., and have internet access for video calls. Excluded are those with psychotic disorders, severe sensory impairments, previous participation by a sibling, certain medication use (except stable SSRIs or psychostimulants), current major depression or anhedonia in children, developmental disabilities, recent mother's substance abuse, or any bipolar disorder history.

Inclusion Criteria

Child and mother have access to a computer or tablet and internet for videoconferencing
Child and biological mother can read and speak fluently in English
For compensation purposes, child and biological mothers must be U.S. citizens
See 1 more

Exclusion Criteria

I have not been diagnosed with major depression or experienced persistent sadness.
If your mother has been in the study with a sibling, you can't participate.
My child is on a stable dose of medication for emotional or behavioral issues, not including SSRIs, for 6 weeks.
See 5 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive the Family Promoting Positive Emotion (F-PPE) intervention or a psychoeducation comparison condition through 8 telehealth sessions

8 weeks
8 telehealth sessions

Assessment

EEG assessments of neural reward responsiveness are conducted at baseline and halfway through the intervention

8 weeks
2 EEG assessments

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Family Promoting Positive Emotions
  • Psychoeducation
Trial Overview The study examines if teaching families to focus on positive emotions can prevent loss of pleasure (anhedonia) in kids whose moms had depression. It involves family-based activities promoting happiness and education about mental health. Participants will engage through online sessions.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Family Promoting Positive EmotionsExperimental Treatment1 Intervention
Group II: PsychoeducationActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Vanderbilt University

Lead Sponsor

Trials
714
Recruited
6,143,000+

Nationwide Children's Hospital

Collaborator

Trials
354
Recruited
5,228,000+

Findings from Research

Anhedonia, the inability to feel pleasure, is linked to reduced activity in brain systems related to dopamine and may contribute to the onset and relapse of drug addiction.
Preventive strategies, such as behavioral activation and positive psychology, can help individuals manage anhedonia and reduce the risk of drug misuse, suggesting that school-based programs could be effective in addressing this issue.
Substance misuse prevention: addressing anhedonia.Sussman, S., Leventhal, A.[2021]
The study aims to assess the feasibility of adding a positive mental imagery training (PMIT) module to standard inpatient mental health treatment, with a focus on increasing positive affect and reducing anhedonia in up to 90 patients over a 2-week period.
By comparing PMIT with cognitive control training and standard treatment alone, the research will provide insights into the potential effectiveness of PMIT as an adjunct therapy, which could lead to improved recovery outcomes in mental health settings.
Computerized positive mental imagery training versus cognitive control training versus treatment as usual in inpatient mental health settings: study protocol for a randomized controlled feasibility trial.Blackwell, SE., Westermann, K., Woud, ML., et al.[2022]
Recent approaches to treating anhedonia, a common symptom in depression and anxiety, focus on enhancing positive emotions by targeting the brain's reward systems, showing preliminary effectiveness in improving reward anticipation and responsiveness.
There is a need for more treatments that specifically address positive emotion regulation and to standardize how anhedonia is measured, which could help in understanding and improving long-term outcomes for individuals suffering from this condition.
Psychological Treatments for Anhedonia.Sandman, CF., Craske, MG.[2022]

References

Substance misuse prevention: addressing anhedonia. [2021]
Computerized positive mental imagery training versus cognitive control training versus treatment as usual in inpatient mental health settings: study protocol for a randomized controlled feasibility trial. [2022]
Psychological Treatments for Anhedonia. [2022]
Treatment for Anhedonia: A Neuroscience Driven Approach. [2022]
Personalized lifestyle advice alters affective reactivity to negative events in anhedonic young adults. [2021]
Improving Pleasure and Motivation in Schizophrenia: A Randomized Controlled Clinical Trial. [2020]
Reciprocal associations between positive emotions and motivation in daily life: Network analyses in anhedonic individuals and healthy controls. [2019]
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