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Cognitive Rehab & Aerobic Exercise for Multiple Sclerosis

N/A

Waitlist Available

Led By Anthony Feinstein, MD

Research Sponsored by Sunnybrook Health Sciences Centre

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 12 weeks, 6 months

Awards & highlights

Study Summary

This trial will test the effectiveness of cognitive rehabilitation and exercise for people with secondary progressive MS who are cognitively impaired.

Eligible Conditions

Multiple Sclerosis
Cognitive Impairment

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 12 weeks, 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 12 weeks, 6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 12 weeks, 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change from baseline cognitive Information processing speed at 12 weeks and 6 months

Secondary outcome measures

Change from baseline anxiety & depression, at 12 weeks and 6 months

Change from baseline cognitive verbal memory at 12 weeks and 6 months

Change from baseline cognitive visual memory at 12 weeks and 6 months

+7 more

Other outcome measures

Change from baseline brain activity at 12 weeks and 6 months

Trial Design

4Treatment groups

Active Control

Placebo Group

Group I: Cognitive Rehab & Aerobic ExerciseActive Control2 Interventions

Cognitive Rehabilitation by computer based brain tasks and aerobic exercises will focus primarily on improving cardio-respiratory fitness using a recumbent bike. Sessions will take place twice a week for 12 weeks.

Group II: Sham Cognitive rehab & Aerobic ExercisePlacebo Group2 Interventions

Sham cognitive rehabilitation will consist of basic internet searches and learning to use a computer, and aerobic exercises will focus primarily on improving cardio-respiratory fitness using a recumbent bike. Sessions will take place twice a week for 12 weeks.

Group III: Cognitive Rehab & Sham ExercisePlacebo Group2 Interventions

Cognitive Rehabilitation by computer based brain tasks, and Sham exercises focusing primary on balance and stretching. Sessions will take place twice a week for 12 weeks.

Group IV: Sham Cognitive Rehab & Sham ExercisePlacebo Group2 Interventions

Sham cognitive Rehabilitation will consist of basic internet searches and learning to use a computer, and sham exercises focusing primary on balance and stretching. Sessions will take place twice a week for 12 weeks.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Unity Health TorontoOTHER

539 Previous Clinical Trials

447,456 Total Patients Enrolled

4 Trials studying Multiple Sclerosis

630 Patients Enrolled for Multiple Sclerosis

Fondazione Italiana Sclerosi MultiplaOTHER

15 Previous Clinical Trials

5,793 Total Patients Enrolled

15 Trials studying Multiple Sclerosis

5,793 Patients Enrolled for Multiple Sclerosis

University College, LondonOTHER

834 Previous Clinical Trials

38,910,090 Total Patients Enrolled

9 Trials studying Multiple Sclerosis

2,114 Patients Enrolled for Multiple Sclerosis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has recruitment for this experiment begun?

"Clinicaltrials.gov reveals that this medical research project is no longer enrolling participants, as the latest update was made on April 25th 2022. Despite its closure however, 690 other trials are actively recruiting patients at present."

Answered by AI

Is there an age ceiling on enrollment in this study?

"This trial is seeking patients between the ages of 25 and 65. Alternatively, there are 50 clinical trials for minors under 18 years old, as well as 519 studies that accept participants over 65."

Answered by AI

Could I be a potential candidate for this experiment?

"This medical trial is recruiting 309 people with primary progressive multiple sclerosis between the ages of 25 and 65. To be considered, applicants must demonstrate language proficiency as well as a visual acuity level of 20/70 or higher."

Answered by AI

Recent research and studies

BMC NeurologyJournal

Study Protocol: Improving Cognition in People with Progressive Multiple Sclerosis: A Multi-arm, Randomized, Blinded, Sham-controlled Trial of Cognitive Rehabilitation and Aerobic Exercise (cogex)

Feinstein, Anthony, On behalf of the CogEx Research Team, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy Chiaravalloti, Ulrik Dalgas, et al.. 2020. “Study Protocol: Improving Cognition in People with Progressive Multiple Sclerosis: A Multi-arm, Randomized, Blinded, Sham-controlled Trial of Cognitive Rehabilitation and Aerobic Exercise (cogex)”. BMC Neurology. Springer Science and Business Media LLC. doi:10.1186/s12883-020-01772-7.

Journal of NeurologyJournal

The Impact of the COVID-19 Pandemic on an International Rehabilitation Study in MS: The Cogex Experience

Feinstein, Anthony, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, et al.. 2021. “The Impact of the COVID-19 Pandemic on an International Rehabilitation Study in MS: The Cogex Experience”. Journal of Neurology. Springer Science and Business Media LLC. doi:10.1007/s00415-021-10881-3.

Journal of NeurologyJournal

The Impact of the COVID-19 Pandemic on an International Rehabilitation Study in MS: The Cogex Experience

Journal of NeurologyJournal

The Late Onset of Emotional Distress in People with Progressive Multiple Sclerosis During the Covid-19 Pandemic: Longitudinal Findings from the Cogex Study