Laser Treatment for Scars and Scleroderma
Trial Summary
What is the purpose of this trial?
In this study, the investigators seek to evaluate the effects of a laser treatment on the redistribution/regeneration of collagen on the clinical, microscopic, and molecular profiles of hypertrophic scars and scleroderma.
Will I have to stop taking my current medications?
The trial requires that you have not used any prescription or in-clinic medications on the eligible scars or scleroderma in the past 3 months, and you should not be taking high doses of anti-inflammatory or immunosuppressive drugs regularly. If you are on these medications, you may need to stop them before participating.
What data supports the effectiveness of the treatment Laser Treatment for scars and scleroderma?
Research shows that laser treatment is effective for improving the appearance of various types of scars, such as burn scars and surgical scars, by reducing thickness, improving texture, and preventing excessive scar growth. This suggests that laser treatment could also be beneficial for managing scars in scleroderma.12345
Is laser treatment generally safe for humans?
Laser treatments, including those for skin resurfacing and scar improvement, are generally considered safe with a low risk of complications. Most side effects are mild and temporary, such as redness and swelling, but more serious issues like scarring are rare. Safety data from various studies suggest that while complications can occur, they are not common and can often be managed effectively.678910
How is laser treatment unique for scars and scleroderma?
Laser treatment is unique because it can specifically target and improve the appearance of different types of scars, such as burn scars, by reducing thickness and improving texture. It is more effective than topical treatments and can be used alongside surgery to enhance mobility and reduce scar-related issues.15111213
Research Team
Dieter Manstein, MD, PhD
Principal Investigator
Massachusetts General Hospital
Eligibility Criteria
Adults over 18, willing to consent and follow study rules, in good health based on screening, who can read English. They must have a large hypertrophic scar or scleroderma lesions suitable for treatment. Pregnant individuals, recent trial participants, those using certain medications/treatments for scars/scleroderma, with allergies to anesthetics or taking high doses of anti-inflammatory/immunosuppressive drugs cannot join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive laser treatment on the entire lesion for hypertrophic scars and scleroderma
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Laser Treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts General Hospital
Lead Sponsor