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Behavioral Intervention

Cognitive Adaptation Training for Schizophrenia (CAT-EM Trial)

N/A
Waitlist Available
Led By Dawn Velligan, PhD
Research Sponsored by The University of Texas Health Science Center at San Antonio
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Males and females who have given informed consent.
Be able to have reimbursed home visits as part of treatment
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 6 months, 12 months
Awards & highlights

CAT-EM Trial Summary

This trial will compare the effectiveness of a cognitive adaptation training (CAT) treatment to existing community treatment (CT) for people with schizophrenia. CAT uses environmental supports to bypass cognitive and motivational difficulties associated with schizophrenia. 400 participants will be assessed at baseline and 6 and 12 months.

Who is the study for?
This trial is for adults aged 18-65 with schizophrenia or schizoaffective disorder who can understand assessments, consent to the study, and have a stable living situation without plans to move within a year. They must agree to home visits and not be in an Assertive Community Treatment program or have recent substance dependence.Check my eligibility
What is being tested?
The study compares Cognitive Adaptation Training (CAT), which uses tools like signs and alarms to help patients manage daily tasks, against standard community treatment. It's conducted across several states with evaluations at baseline, 6 months, and 12 months on various health outcomes.See study design
What are the potential side effects?
Since CAT involves non-medical interventions such as environmental supports rather than drugs, traditional side effects are not expected; however, participants may experience stress or discomfort adapting to new routines.

CAT-EM Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have signed a consent form to participate.
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My treatment allows for home visits that are covered by insurance or reimbursement.
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I am between 18 and 65 years old.
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I have been diagnosed with schizophrenia or schizoaffective disorder.
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I agree to let healthcare professionals visit me at home.

CAT-EM Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 6 months, 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 6 months, 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Social and Occupational Functioning Scale Scores
Secondary outcome measures
Change in Adherence Estimate Score
Change in Daily activity
Change in Multnomah Community Ability Scale mean score
+2 more
Other outcome measures
Change in Effort Expenditure for Rewards Task (EEfRT) Probability Difference score
Change in global score of Brief Assessment of Cognition (BACS) App

CAT-EM Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive Adaptation TrainingExperimental Treatment1 Intervention
Psychosocial treatment using environmental supports such as signs, alarms, pill containers, checklists, technology and the organization of belongings established in a person's home or work environment to bypass the cognitive and motivational difficulties associated with schizophrenia, and support habits for functional behavior to promote recovery.
Group II: Community TreatmentActive Control1 Intervention
Medication follow-up and case management as provided by the community mental health center according to usual care.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cognitive Adaptation Training
2009
N/A
~420

Find a Location

Who is running the clinical trial?

The University of Texas Health Science Center at San AntonioLead Sponsor
452 Previous Clinical Trials
91,209 Total Patients Enrolled
Vanguard Research GroupOTHER
1 Previous Clinical Trials
489 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,782 Previous Clinical Trials
2,688,902 Total Patients Enrolled

Media Library

Cognitive Adaptation Training (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT03829280 — N/A
Schizoaffective Disorder Research Study Groups: Cognitive Adaptation Training, Community Treatment
Schizoaffective Disorder Clinical Trial 2023: Cognitive Adaptation Training Highlights & Side Effects. Trial Name: NCT03829280 — N/A
Cognitive Adaptation Training (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03829280 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this study accept volunteers aged 25 or older?

"This trial is seeking participants who are of legal adult age and under the retirement age."

Answered by AI

What places are offering this trial to participants?

"Eight clinical sites are currently in the process of enrolling participants. These locations include Dayville, Manchester and Lauderdale Lakes as well as 5 other cities. To reduce unnecessary travel commitments, it is advised to select a clinic nearest you if you choose to partake in this trial."

Answered by AI

To what extent is the patient population involved in this experiment?

"To ensure the success of this trial, 500 qualified patients must be enrolled. Those interested may register at United Services Inc. in Dayville, Connecticut and Mental health Center of Greater Manchester in Manchester, New hampshire."

Answered by AI

Is enrollment for this clinical trial still available?

"Affirmative. Clinicaltrials.gov highlights that this experiment is currently enrolling people, and the trial was first published on April 4th 2019 before being amended June 17th 2022. A total of 500 men and women are needed from 8 distinct research centres."

Answered by AI

Is it possible to enroll in this clinical research?

"Qualified participants of this research trial must be between the ages 18 and 65, currently have schizophrenia, maintain at least three months of stable housing (including individual apartments or family homes), agree to home visits for treatment purposes, comprehend rating scales/assessments, and receive reimbursement for these home visits. In total 500 patients are being accepted into this study."

Answered by AI

Who else is applying?

What state do they live in?
Texas
What site did they apply to?
The Harris Center for Mental Health & IDD
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1
Recent research and studies
clinicaltrials.govStudy
Cognitive Adaption Training-Effectiveness in Real-world Settings and Mechanism of Action (CAT-EM)
Dawn Velligan 2019. "Cognitive Adaption Training-Effectiveness in Real-world Settings and Mechanism of Action (CAT-EM)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03829280.
All > Schizophrenia
~34 spots leftby Apr 2025
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