Cognitive Adaptation Training for Schizophrenia

Phase-Based Estimates
1
Effectiveness
1
Safety
Mental Health Center of Greater Manchester, Manchester, NH
Schizophrenia+2 More
Cognitive Adaptation Training - Behavioral
Eligibility
18+
All Sexes
Eligible conditions
Schizophrenia

Study Summary

This study is evaluating whether a specific type of psychosocial therapy may help improve outcomes for individuals with schizophrenia.

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Eligible Conditions

  • Schizophrenia
  • Psychotic Disorders
  • Schizoaffective Disorders

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Cognitive Adaptation Training will improve 1 primary outcome, 5 secondary outcomes, and 2 other outcomes in patients with Schizophrenia. Measurement will happen over the course of baseline, 6 months, 12 months.

Month 12
Change in Adherence Estimate Score
Change in Daily activity
Change in Effort Expenditure for Rewards Task (EEfRT) Probability Difference score
Change in Multnomah Community Ability Scale mean score
Change in Negative Symptom Assessment-16 Mean Score
Change in Social and Occupational Functioning Scale Scores
Change in global score of Brief Assessment of Cognition (BACS) App
Change in the Expanded Version Brief Psychiatric Rating Scale (BPRS)-total score

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

Community Treatment
Cognitive Adaptation Training

This trial requires 500 total participants across 2 different treatment groups

This trial involves 2 different treatments. Cognitive Adaptation Training is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Cognitive Adaptation Training
Behavioral
Psychosocial treatment using environmental supports such as signs, alarms, pill containers, checklists, technology and the organization of belongings established in a person's home or work environment to bypass the cognitive and motivational difficulties associated with schizophrenia, and support habits for functional behavior to promote recovery.
Community Treatment
Behavioral
Medication follow-up and case management as provided by the community mental health center according to usual care.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cognitive Adaptation Training
2009
N/A
~420

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, 6 months, 12 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline, 6 months, 12 months for reporting.

Closest Location

Mental Health Center of Greater Manchester - Manchester, NH

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Can provide evidence of a stable living environment (individual apartment, family home, board and care facility) in the last three months and no plans to move in the next year. show original
The author suggests that the parents of the child should agree to home visits show original
People who have given consent after being fully informed. show original
People aged between 18 and 65 can get a flu vaccine. show original
A mental health clinician makes a diagnosis of schizophrenia or schizoaffective disorder after taking a complete history, doing a mental status exam, and observing the person's behavior show original
Being able to have reimbursed home visits as part of treatment would be extremely helpful for those who are struggling with their mental health show original
Able to understand and complete rating scales and assessments proficiently. show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the latest research for schizophrenia?

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This is a review of what's said about schizophrenia in popular media, scientific literature, and other sources. Attention to this information may influence treatment planning and improve patient care.

Unverified Answer

What are the signs of schizophrenia?

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Signs typically involve speech (or inability to speak), thinking, and movement. They may also include hallucinations, delusions, disorganized or paranoid behaviour, and auditory, visual, and tactile hallucinations.\n

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What are common treatments for schizophrenia?

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Shorter hospitalizations in schizophrenic patients who take atypical antipsychotics are mainly attributable to other treatment regimens and not only to their antipsychotic effect; this pattern of shorter hospitalizations is not seen in those who take typical antipsychotics.

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Can schizophrenia be cured?

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Psychosis is not curable. The only way to cure is to help everyone experiencing psychosis to feel they have a great future and to be happy. Psychosis can be treated with good psychosocial support but more research is needed to examine which specific treatments are successful.

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How many people get schizophrenia a year in the United States?

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The incidence per year of those with a diagnosis of schizophrenia is 24.44. This is one of the highest in the world and higher than that of many other Western nations.

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What is schizophrenia?

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The first signs of schizophrenia appear in very young children and young teens. The onset is characterized by hallucinations that may resemble normal childhood experiences, such as seeing a cartoon character that walks backwards to the other side of the screen. Children in the early stages of the condition may be confused due to the hallucinations or simply get lost in it. Some may stop playing and become withdrawn, while others may become aggressive or fearful. The hallucinations soon decrease in intensity and the child is able to tell the difference between a mental illness and the normal childhood experiences. Eventually, the child may be diagnosed, most often by a psychiatrist or a psychologist in the private or public sector.

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What causes schizophrenia?

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There is an increased prevalence of schizophrenia in some demographic or socioeconomic groups. There is an inverse relationship between duration of illness and the prevalence of schizophrenia. The cause of schizophrenia remains unknown. The impact of schizophrenia has been a major problem for human society. One of the things that is different between patients, and researchers, is the duration of the lifetime, which plays a very important role in the progress of the illness.

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Have there been other clinical trials involving cognitive adaptation training?

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Cognitive adaptation training represents an intriguing therapeutic approach for patients with schizophrenia and may be useful for modifying the cognitive and behavioral mechanisms responsible for relapse after admission.

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What does cognitive adaptation training usually treat?

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Cognitive adaptation/response prevention treatment is generally considered to be more effective than standard cognitive-behavioral therapies in the treatment of schizophrenia and borderline personality disorder. Patients with schizophrenia or borderline personality disorder who have poor response to standard CBT have a higher likelihood of responding to cognitive-adaptation-based interventions than patients who are responsive to CBT in standard treatment protocols.

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What are the latest developments in cognitive adaptation training for therapeutic use?

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Cognitive adaptation training is an effective tool for improving the functioning of chronically ill patients. It can also be used to reduce psychotic symptoms in those patients.

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Does schizophrenia run in families?

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Because the family aggregation of non-affective psychosis (i.e., personality disorder, and schizophrenia) seems to be stronger than that of schizophrenia, family aggregation might be expected to be an important feature of familial transmission of non-affective psychosis. This is inconsistent with the findings of a study on parental and children’s risk factors of schizophrenia that a strong family aggregation of schizophrenia exists in children but not in their parents. It is possible that in family-based research of schizophrenia, the parental generation might not be of appropriate age.

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How does cognitive adaptation training work?

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In a recent study, findings, with respect to the cognitive adaptation training intervention, were encouraging, indicating that more work needs to be done in the area in order to increase their therapeutic effectiveness.

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