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Behavioural Intervention

Music Therapy for Schizophrenia (SING_R33 Trial)

Led By Philip R Corlett, PhD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up baseline and within one week of study completion (final mi session of 4)
Awards & highlights


This trial investigates how music intervention can help people with voice-hearing in the context of a psychotic illness, with the ultimate goal of finding the most effective way to use this intervention.

Who is the study for?
This trial is for individuals who hear voices daily and have been diagnosed with a psychotic disorder as per the Diagnostic and Statistical Manual-V. They must exhibit moderate hallucinations, be able to give informed consent, interact well with the study team, and likely complete the study.Check my eligibility
What is being tested?
The SING trial tests how different forms of musical intervention affect people with schizophrenia. Participants are randomly assigned to create music, perform karaoke, listen to pop music or curate playlists. The impact on hallucinations, social learning, and language use is measured.See study design
What are the potential side effects?
Since this trial involves musical interventions rather than medications or invasive procedures, traditional side effects are not expected. However, participants may experience varying psychological responses based on their interaction with music.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and within one week of study completion (final mi session of 4)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and within one week of study completion (final mi session of 4) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Conditioned Hallucinations
Change in Language Use
Change in Social Belief Updating

Trial Design

1Treatment groups
Experimental Treatment
Group I: Musical InterventionExperimental Treatment1 Intervention
Participants will work together in a group with other voice hearers, making music with a trained facilitator for 4 weekly sessions
First Studied
Drug Approval Stage
How many patients have taken this drug
Musical Intervention

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for schizophrenia include antipsychotic medications and psychosocial interventions. Antipsychotic medications work by modulating neurotransmitter systems, particularly dopamine and serotonin, to reduce symptoms like hallucinations and delusions. Psychosocial interventions, such as cognitive-behavioral therapy (CBT), social skills training, and family-based interventions, aim to improve cognitive and social functioning. The Musical Intervention (MI) being studied leverages the predictive processing framework, focusing on active participation and ownership in music creation to enhance cognitive processes and social interactions. This holistic approach is crucial for improving both symptom management and overall quality of life for schizophrenia patients.
Group therapy for schizophrenia: A meta-analysis.Relapse prevention in ambulant mental health care tailored to patients with schizophrenia or bipolar disorder.Treatment of early onset schizophrenia: recent trends, challenges and future considerations.

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,874 Previous Clinical Trials
2,953,356 Total Patients Enrolled
59 Trials studying Schizophrenia
3,819 Patients Enrolled for Schizophrenia
National Institute of Mental Health (NIMH)NIH
2,820 Previous Clinical Trials
2,692,619 Total Patients Enrolled
250 Trials studying Schizophrenia
89,261 Patients Enrolled for Schizophrenia
Philip R Corlett, PhDPrincipal InvestigatorYale University
2 Previous Clinical Trials
40 Total Patients Enrolled
2 Trials studying Schizophrenia
40 Patients Enrolled for Schizophrenia

Media Library

Musical Intervention (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05929352 — N/A
Schizophrenia Research Study Groups: Musical Intervention
Schizophrenia Clinical Trial 2023: Musical Intervention Highlights & Side Effects. Trial Name: NCT05929352 — N/A
Musical Intervention (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05929352 — N/A
~44 spots leftby Jan 2025