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Motor Rehabilitation for Stroke
N/A
Waitlist Available
Led By Yousef Hannawi, MD
Research Sponsored by Ohio State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up participants will be followed for 4-6 weeks. change in motor function at mid-treatment (after 1 week of ci therapy), post-treatment (after 2 weeks of therapy), and at 2-week follow-up will be measured.
Awards & highlights
Study Summary
This trial will help researchers understand how constraint-induced movement therapy (CI therapy) helps the brain "rewire" itself after stroke, in hopes of improving rehabilitation methods.
Who is the study for?
This trial is for adults over 18 who had a stroke at least 6 months ago, resulting in mild to moderate hemiparesis but can still understand and participate in therapy. It's not for those with severe medical conditions, recent botulinum toxin injections, intensive post-stroke rehab, kidney issues, metallic/electronic implants incompatible with MRI, or claustrophobia.Check my eligibility
What is being tested?
The study tests Constraint-induced movement therapy (CI therapy) which helps the brain 'rewire' after chronic stroke. Using advanced MRI techniques to observe changes in grey matter and blood flow will infer cellular processes behind brain reorganization during CI therapy.See study design
What are the potential side effects?
Since this trial involves non-invasive MRI scans and physical rehabilitation exercises rather than drugs or invasive procedures, side effects are minimal but may include discomfort from remaining still during scans or fatigue from the exercises.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ participants will be followed for 4-6 weeks. change in brain structure at mid-treatment (after 1 week of ci therapy), post-treatment (after 2 weeks of therapy), and at 2-week follow-up will be measured.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~participants will be followed for 4-6 weeks. change in brain structure at mid-treatment (after 1 week of ci therapy), post-treatment (after 2 weeks of therapy), and at 2-week follow-up will be measured.
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Brain structure
Secondary outcome measures
Motor function
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Immediate CI therapyExperimental Treatment1 Intervention
Group II: Delayed CI therapyActive Control1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
CI therapy
2010
N/A
~30
Find a Location
Who is running the clinical trial?
Ohio State UniversityLead Sponsor
827 Previous Clinical Trials
502,720 Total Patients Enrolled
12 Trials studying Stroke
4,435 Patients Enrolled for Stroke
Yousef Hannawi, MDPrincipal InvestigatorOhio State University
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Eligibility Criteria:
This trial includes the following eligibility criteria:- My kidney function is reduced with an eGFR below 60.I have anemia.I do not have severe health issues like dementia or uncontrollable pain.You have a device implanted in your brain to control brain activity.You have a permanent tattoo with metallic coloring, like in eye liner.You cannot be participating in other experimental trials for treating motor problems at the same time.I understand and can follow the treatment plan.I have received a botulinum toxin injection in the last 3 months.I have undergone intensive rehabilitation after my stroke.I have sickle cell disease.I had a stroke 6 months ago that caused mild to moderate weakness on one side.I have had a kidney transplant.I have a history of kidney disease.I am 18 years old or older.You feel very uncomfortable in small spaces and cannot have an MRI because of it.You have metal implants or electronic devices that are not safe for MRI scans.
Research Study Groups:
This trial has the following groups:- Group 1: Immediate CI therapy
- Group 2: Delayed CI therapy
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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