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Talazoparib for Advanced Breast Cancer
Study Summary
This trial is testing if talazoparib is safe and effective for treating advanced breast cancer associated with a mutation in the PALB2 gene.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2022 Phase 2 trial • 21 Patients • NCT02401347Trial Design
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Who is running the clinical trial?
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- My cancer can be measured by scans and I've had the required scans recently.My liver functions are within the required limits.I am a woman who can have children, have a negative pregnancy test, and agree to more tests during the study.I can take pills by mouth.My breast cancer is confirmed to be HER2 negative.My cancer did not worsen after or during my last platinum-based treatment.I have had up to 3 treatments for my advanced illness.I have been treated with a PARP inhibitor before.I have brain metastases or leptomeningeal carcinomatosis but am stable and not on high-dose steroids.I am 18 years old or older.I have a harmful BRCA1 or BRCA2 gene mutation.You have a serious infection or bleeding disorder that could affect your ability to take part in the study safely.My kidney function is within the normal range.My breast cancer can be treated with the aim of curing it.You cannot have taken any experimental medications within 28 days before the start of the study.I can take care of myself and am up and about more than half of my waking hours.I have an active hepatitis B or C infection.I have not had radiation therapy in the last 14 days.My blood counts meet the required levels for the study.I have not had major surgery in the last 3 weeks.My side effects from previous cancer treatments are mild, except for hair loss and some nerve pain.I haven't been treated for any cancer except skin cancer or early-stage cervical/breast cancer in the last 3 years.I am willing to use birth control during and for 3 months after the study.I can provide a sample of my tumor, either recent or from a past biopsy.My cancer has a harmful PALB2 mutation confirmed by a specific test.
- Group 1: Talazoparib Arm
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many people are being approved for this clinical experiment?
"Unfortunately, this study is not taking on any more patients at the moment. The original posting was on January 1st 2023 and there have been no updates since November 9th 2022. However, if you're still interested in participating in clinical trials, there are 2702 active studies for breast cancer and 60 for Talazoparib Tosylate."
Are there any dangers that patients should be aware of when taking Talazoparib Tosylate?
"While there is some data suggesting that Talazoparib Tosylate is safe, none of it points to the medication being effective. Consequently, our team at Power gave it a score of 2."
Are people still being sought out to participate in this research?
"Data from clinicaltrials.gov reveals that this particular trial is no longer recruiting patients, as the last update was on November 9th, 2022. It's worth noting that there are 2762 other trials with open recruitment at this time."
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