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rTMS + Cognitive Training for Schizophrenia (CrTMS Trial)

N/A

Recruiting

Research Sponsored by Washington University School of Medicine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 weeks

Awards & highlights

CrTMS Trial Summary

This trial will study whether combining rTMS with cognitive training can improve cognitive and functional outcomes in adults with Schizophrenia or Schizoaffective Disorder.

Who is the study for?

This trial is for adults aged 18-65 with stable psychotic symptoms and a diagnosis of schizophrenia or schizoaffective disorder. It's not suitable for those actively using substances, on meds that affect cognition, currently experiencing severe psychosis, recently hospitalized for psychiatric reasons, or with a history of seizures.Check my eligibility

What is being tested?

The study tests the combination of repetitive transcranial magnetic stimulation (rTMS) and computerized cognitive training to see if they improve thinking and daily functioning in people with schizophrenia. Participants are randomly assigned to receive either real rTMS or a sham treatment over two weeks.See study design

What are the potential side effects?

Potential side effects from rTMS may include discomfort at the stimulation site, headache, lightheadedness, or seizures (though rare). The cognitive training is unlikely to have physical side effects but could cause mental fatigue.

CrTMS Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Differences between groups on neuropsychological functioning

Secondary outcome measures

Differences between groups on disability

Differences between groups on life skills

CrTMS Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: active rTMS with computerized cognitive trainingExperimental Treatment2 Interventions

Participants will receive 6 sessions of active rTMS followed by a computerized cognitive training session over 2 weeks.

Group II: sham rTMS with computerized cognitive trainingPlacebo Group1 Intervention

Participants will receive 6 sessions of sham rTMS followed by a computerized cognitive training session over 2 weeks.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

rTMS

2016

Completed Phase 3

~840

Computerized cognitive training

2016

N/A

~480

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor

1,931 Previous Clinical Trials

2,299,679 Total Patients Enrolled

16 Trials studying Schizophrenia

1,035 Patients Enrolled for Schizophrenia

Media Library

Computerized cognitive training Clinical Trial Eligibility Overview. Trial Name: NCT03741751 — N/A

Schizophrenia Research Study Groups: active rTMS with computerized cognitive training, sham rTMS with computerized cognitive training

Schizophrenia Clinical Trial 2023: Computerized cognitive training Highlights & Side Effects. Trial Name: NCT03741751 — N/A

Computerized cognitive training 2023 Treatment Timeline for Medical Study. Trial Name: NCT03741751 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the highest number of individuals enrolled in this clinical trial?

"Affirmative. Clinicaltrials.gov hosts data which suggests this medical experiment is actively enrolling volunteers; the trial was initially posted on January 15th 2019, and most recently updated August 24th 2022. Thirty participants will be admitted from one centre of recruitment."

Answered by AI

Does this clinical trial offer opportunities for my involvement?

"Aspiring participants of this research trial must be 18-65 years old and have a confirmed diagnosis of schizophrenia. The study is looking to enrol approximately 30 people."

Answered by AI

Is this research project admitting elderly participants aged 85 and above?

"According to the study parameters, only participants within the age range of 18-65 are eligible. 142 trials exclusively focus on those aged below 18 and 490 clinical studies target patients beyond 65 years old."

Answered by AI

Is there an open call for participants in this research?

"Absolutely. According to information posted on clinicaltrials.gov, this research project is currently enrolling participants. It was initially published in January 15th 2019 and last modified on August 24th 2022 with the aim of recruiting 30 individuals from one location."

Answered by AI

Recent research and studies

Progress in Neuro-Psychopharmacology and Biological PsychiatryJournal

Different Forms of Prefrontal Theta Burst Stimulation for Executive Function of Medication- Resistant Depression: Evidence from a Randomized Sham-controlled Study

Cheng, Chih-Ming, Chi-Hung Juan, Mu-Hong Chen, Chi-Fu Chang, Hsin Jie Lu, Tung-Ping Su, Ying-Chiao Lee, and Cheng-Ta Li. 2016. “Different Forms of Prefrontal Theta Burst Stimulation for Executive Function of Medication- Resistant Depression: Evidence from a Randomized Sham-controlled Study”. Progress in Neuro-psychopharmacology and Biological Psychiatry. Elsevier BV. doi:10.1016/j.pnpbp.2015.11.009.

Psychiatry ResearchJournal

The Canadian Objective Assessment of Life Skills (COALS): A New Measure of Functional Competence in Schizophrenia

McDermid Vaz, Stephanie A., R. Walter Heinrichs, Ashley A. Miles, Narmeen Ammari, Suzanne Archie, Eva Muharib, and Joel O. Goldberg. 2013. “The Canadian Objective Assessment of Life Skills (COALS): A New Measure of Functional Competence in Schizophrenia”. Psychiatry Research. Elsevier BV. doi:10.1016/j.psychres.2012.10.020.

The Journal of Clinical PsychiatryJournal

Transcranial Magnetic Stimulation in the Treatment of Major Depressive Disorder

Janicak, Philip G., John P. O'Reardon, Shirlene M. Sampson, Mustafa M. Hussain, Sarah H. Lisanby, Jeffrey T. Rado, Karen L. Heart, and Mark A. Demitrack. 2008. “Transcranial Magnetic Stimulation in the Treatment of Major Depressive Disorder”. The Journal of Clinical Psychiatry. Physicians Postgraduate Press, Inc. doi:10.4088/jcp.v69n0208.

International PsychogeriatricsJournal