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CVS Reactivity in Schizophrenia
N/A
Waitlist Available
Led By Philip Gerretsen, MD, PhD
Research Sponsored by Centre for Addiction and Mental Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up between 30 and 60 sec after each cvs condition
Awards & highlights
Study Summary
This trial will test if people with schizophrenia have a stronger reaction to vestibular stimulation than people without the condition. The reaction will be measured using electronystagmography, which tracks eye movement. If the study shows that people with schizophrenia have a stronger reaction, it could suggest that the vestibular system is a marker for the condition.
Who is the study for?
This trial is for adults over 18 with schizophrenia or schizoaffective disorder, who can consent to participate and speak English fluently. Healthy adults without psychiatric illness are also eligible. It's not suitable for those unable to give informed consent or non-English speakers.Check my eligibility
What is being tested?
The study tests how people with schizophrenia versus healthy individuals react to different types of vestibular stimulation (cold, warm, body temperature) in each ear. The response is measured using electronystagmography which tracks eye movements as an indicator of vestibular activity.See study design
What are the potential side effects?
Vestibular stimulation may cause temporary dizziness, imbalance, nausea, or abnormal eye movements during the test. These side effects result from stimulating the inner ear balance system but typically resolve shortly after the procedure.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ between 30 and 60 sec after each cvs condition
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~between 30 and 60 sec after each cvs condition
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Nystagmus response (peak slow phase velocity)
Secondary outcome measures
Illness awareness
Trial Design
6Treatment groups
Experimental Treatment
Group I: Right warm CVSExperimental Treatment1 Intervention
Right warm (44°C) caloric vestibular stimulation
Group II: Right cold CVSExperimental Treatment1 Intervention
Right cold (30°C) caloric vestibular stimulation
Group III: Right body temperature VSExperimental Treatment1 Intervention
Right body temperature (37°C) vestibular stimulation
Group IV: Left warm CVSExperimental Treatment1 Intervention
Left warm (44°C) caloric vestibular stimulation
Group V: Left cold CVSExperimental Treatment1 Intervention
Left cold (30°C) caloric vestibular stimulation
Group VI: Left body temperature VSExperimental Treatment1 Intervention
Left body temperature (37°C) vestibular stimulation
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Left warm CVS
2019
N/A
~40
Right warm CVS
2019
N/A
~40
Left cold CVS
2019
N/A
~40
Left body temperature VS
2019
N/A
~40
Right body temperature VS
2019
N/A
~40
Right cold CVS
2019
N/A
~40
Find a Location
Who is running the clinical trial?
Centre for Addiction and Mental HealthLead Sponsor
356 Previous Clinical Trials
81,404 Total Patients Enrolled
58 Trials studying Schizophrenia
4,191 Patients Enrolled for Schizophrenia
Philip Gerretsen, MD, PhDPrincipal InvestigatorCentre for Addiction and Mental Health
5 Previous Clinical Trials
254 Total Patients Enrolled
4 Trials studying Schizophrenia
194 Patients Enrolled for Schizophrenia
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:Research Study Groups:
This trial has the following groups:- Group 1: Left body temperature VS
- Group 2: Left cold CVS
- Group 3: Left warm CVS
- Group 4: Right cold CVS
- Group 5: Right body temperature VS
- Group 6: Right warm CVS
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any vacancies for participants in this research study?
"According to clinicaltrials.gov, this research trial is accepting participants and the initial posting was on January 1st 2019 with a recent update occurring June 2nd 2022."
Answered by AI
What is the size of the sample population for this research project?
"Affirmative. According to the data found on clinicaltrials.gov, this medical research is actively seeking enrolment candidates; it was initially made public on January 1st 2019 and its most recent update took place on June 2nd 2022. The study requires 40 participants to be recruited from one site only."
Answered by AI
Who else is applying?
What site did they apply to?
Centre for Addiction and Mental Health
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0
What questions have other patients asked about this trial?
Why did patients apply to this trial?
Joining a clinical trial is a choice I've made with a strong sense of purpose. It enables me to contribute to medical research, potentially benefiting many people through the development of new treatments.
I'm also excited by the opportunity to access novel treatments before they're broadly accessible. Plus, I value the thorough care and monitoring during trials, ensuring immediate response to any health changes.
PatientReceived 1 prior treatment
How responsive is this trial?
Most responsive sites:
- Centre for Addiction and Mental Health: < 24 hours
Typically responds via
Email
Average response time
- < 1 Day
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