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rTMS for Schizophrenia
N/A
Waitlist Available
Led By Roscoe Brady, MD, PhD
Research Sponsored by Beth Israel Deaconess Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up before treatment (baseline) and 1 week post treatment
Awards & highlights
Study Summary
This trial is testing whether transcranial magnetic stimulation (TMS) can help improve negative symptoms of schizophrenia, like anhedonia, low motivation, and decreased facial expression.
Eligible Conditions
- Schizophrenia
- Schizoaffective Disorder
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ before treatment (baseline) and 1 week post treatment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~before treatment (baseline) and 1 week post treatment
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in Negative Symptom Severity
Secondary outcome measures
Hallucinations, Auditory
Change in Cerebellar - Prefrontal Functional Connectivity
Trial Design
4Treatment groups
Active Control
Placebo Group
Group I: Active DLPFC rTMSActive Control1 Intervention
Active repetitive Transcranial Magnetic Stimulation (rTMS) with iTBS pattern to the right DLPFC at 80% of active motor threshold.
Group II: Active cerebellum rTMSActive Control1 Intervention
Active repetitive Transcranial Magnetic Stimulation (rTMS) with iTBS pattern to the cerebellum at 100% of active motor threshold.
Group III: Sham DLPFC rTMSPlacebo Group1 Intervention
Sham repetitive Transcranial Magnetic Stimulation (rTMS) with iTBS pattern to the right DLPFC
Group IV: Sham cerebellum rTMSPlacebo Group1 Intervention
Sham repetitive Transcranial Magnetic Stimulation (rTMS) with iTBS pattern to the cerebellum
Find a Location
Who is running the clinical trial?
Beth Israel Deaconess Medical CenterLead Sponsor
837 Previous Clinical Trials
13,010,225 Total Patients Enrolled
21 Trials studying Schizophrenia
1,955 Patients Enrolled for Schizophrenia
Mclean HospitalOTHER
213 Previous Clinical Trials
21,647 Total Patients Enrolled
19 Trials studying Schizophrenia
1,375 Patients Enrolled for Schizophrenia
Harvard UniversityOTHER
229 Previous Clinical Trials
474,458 Total Patients Enrolled
4 Trials studying Schizophrenia
436 Patients Enrolled for Schizophrenia
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have had a serious head injury that caused you to lose consciousness for more than 15 minutes or have lasting neurological problems.You have struggled with drug or alcohol addiction in the past three months.You have ongoing, frequent headaches that are not well managed, including needing medicine every day to prevent migraines.You have a history of seizures or epilepsy, or someone in your immediate family has epilepsy, except if you had a single seizure that was not serious and was caused by something like a fever, according to a specialized doctor.You cannot use both hands equally well (ambidextrous) for the task.You have a history of fainting spells that doctors couldn't determine the cause of, and they might be like seizures.You have been diagnosed with schizophrenia or schizoaffective disorder based on specific criteria used by doctors.You have long-term medical conditions, like heart problems or asthma, that are not well controlled and could put you at risk of a medical emergency if you were to have a seizure.You have a history of ongoing or inherited neurological disorders like Parkinson's disease, multiple sclerosis, or Alzheimer's disease. You are also excluded if you have had a neurological disease caused by factors like stroke, brain injury, or tumors.
Research Study Groups:
This trial has the following groups:- Group 1: Active DLPFC rTMS
- Group 2: Sham DLPFC rTMS
- Group 3: Sham cerebellum rTMS
- Group 4: Active cerebellum rTMS
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is the research team actively seeking new participants at this time?
"Per the details featured on clinicaltrials.gov, this medical trial is actively recruiting. It was initially posted on May 2nd 2019 and most recently updated on October 25th 2021."
Answered by AI
Does my profile meet the qualifications for this research endeavor?
"This medical experiment is aiming to recruit 68 patients who suffer from schizophrenia and are aged between 18-55. It's imperative that these individuals must remain in stable outpatient treatment for the past month, with no modifications made to their medication regimens; additionally, they must be deemed able to complete trial proceedings by study personnel."
Answered by AI
Does this medical experiment accept those under 85 years of age?
"The eligibility criteria for this research specifies that patients must be aged between 18 and 55. Separate trials exist for those under the age of 18 (106) or over 65 (243)."
Answered by AI
What is the total patient enrollment for this clinical evaluation?
"Correct. According to clinicaltrials.gov, this experimental treatment is actively recruiting patients since its initial posting on May 2nd 2019 and latest update of October 25th 2021. Sixty-eight people are needed at 1 medical site for the study's completion."
Answered by AI
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