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visual training condition for Schizophrenia

N/A
Waitlist Available
Led By Judy L. Thompson, Ph.D.
Research Sponsored by Rutgers, The State University of New Jersey
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up approximately 14 weeks (baseline and post-treatment)
Awards & highlights

Study Summary

Schizophrenia is a severe psychiatric condition that is associated with significant distress and disability. In addition to cognitive difficulties in domains such as attention, memory, and problem-solving, individuals with schizophrenia can experience visual-processing abnormalities, including impairments in visual acuity, low-contrast stimulus detection, and perceptual organization (i.e., perceiving visual information in an organized "perceptual whole"). These visual impairments are clinically significant, with research indicating that specific visual-processing alterations are significantly related to poorer performance on higher-level cognitive tasks, impaired facial emotion recognition, impaired reading ability, and worse functional outcomes. Despite such findings, very few studies have evaluated the therapeutic potential of interventions that are specifically designed to improve visual processing ("visual remediation") for individuals with schizophrenia. Thus the aim of this study is to evaluate the efficacy of a computerized visual perceptual training program that targets low- and mid-level visual processes to improve visual, cognitive, and emotion-recognition functions in outpatients with schizophrenia through a small randomized controlled trial. The investigators will recruit up to 40 individuals with schizophrenia or schizoaffective disorder who are receiving treatment in Rutgers University Behavioral Health Care (UBHC) Partial Hospital Program; half will be randomized to receive the computerized visual training, which will be delivered in small groups over a period of 12-14 weeks. The specific aims of this study are to collect preliminary data on: 1) the feasibility of participant recruitment and retention, and tolerability of the treatment components of the study; and 2) the efficacy of computerized visual training (VT) to improve low- and mid-level visual processes, and higher-level cognitive and social-cognitive performance. Based on preliminary data, the investigators hypothesize that the target number of participants will be successfully recruited and engaged in the VT intervention (n=16) and control condition (n=16), and that the participants who receive VT will demonstrate greater improvements on measures of low- and mid-level visual, higher-level cognitive, and social-cognitive functions compared to those who receive standard partial-hospital care without VT. The results of this initial trial will be used to inform the design and application for funding of a larger-scale investigation of visual remediation for individuals with schizophrenia.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~approximately 14 weeks (baseline and post-treatment)
This trial's timeline: 3 weeks for screening, Varies for treatment, and approximately 14 weeks (baseline and post-treatment) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
contour integration
contrast sensitivity

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: visual training conditionExperimental Treatment1 Intervention
Participants in the visual training condition will participate in the visual training (VT) group, during which they will complete computerized visual training that targets low- and mid-level visual processes. Each group will include a maximum of 3 participants and will meet 3 times a week over a period of 12-14 weeks.
Group II: control conditionActive Control1 Intervention
Participants assigned to the control condition will receive standard Partial Hospital care without visual training.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Visual Training
2017
N/A
~30

Find a Location

Who is running the clinical trial?

Nathan Kline Institute for Psychiatric ResearchOTHER
37 Previous Clinical Trials
2,788 Total Patients Enrolled
31 Trials studying Schizophrenia
2,089 Patients Enrolled for Schizophrenia
University of California, RiversideOTHER
24 Previous Clinical Trials
12,216 Total Patients Enrolled
Rutgers, The State University of New JerseyLead Sponsor
429 Previous Clinical Trials
64,192 Total Patients Enrolled
5 Trials studying Schizophrenia
428 Patients Enrolled for Schizophrenia

Frequently Asked Questions

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~5 spots leftby Apr 2025