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Behavioral Intervention
Resistance Training for High Blood Pressure Control in Sarcopenia (INERTIA Trial)
N/A
Waitlist Available
Led By Deepika Laddu, PhD
Research Sponsored by University of Illinois at Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Adults (men and women) aged 60 years and older (any racial/ethnic background)
Demonstrates adequate cognitive function by the MoCA (education adjusted score of >22 at screening)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 8 weeks 12 weeks, 1 year
Awards & highlights
INERTIA Trial Summary
This trial will study the effects of an exercise intervention on blood pressure in older adults with sarcopenia, in order to better understand how muscle strength affects blood pressure and identify potential targets for non-pharmacological treatments for high blood pressure.
Who is the study for?
This trial is for adults aged 60 and older, who are sedentary or not very active, can walk without full assistance, have good cognitive function (MoCA score >22), and live in the Chicagoland area. It's not for those with recent serious cardiovascular events, cancer treatments within 5 years, severe orthopedic issues preventing exercise, autoimmune diseases that limit safe exercising, or substance abuse problems.Check my eligibility
What is being tested?
The study tests how well progressive resistance training can control high blood pressure in older adults with sarcopenia. Participants will be randomly assigned to two groups to compare muscle strength impact on blood pressure over a three-month period with a follow-up at twelve months.See study design
What are the potential side effects?
While specific side effects aren't listed for resistance training interventions like this one, participants may experience general exercise-related discomforts such as muscle soreness or fatigue.
INERTIA Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
Adults who are 60 years old or older, no matter what race they are.
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You have good thinking and memory skills, as measured by a test called the MoCA, and you score higher than 22.
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Adults who don't exercise regularly or don't do strength training.
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Lives in the Chicagoland area.
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You can walk or exercise without needing a device to help you.
INERTIA Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, 8 weeks 12 weeks, 1 year
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 8 weeks 12 weeks, 1 year
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in blood pressure
Secondary outcome measures
Short Physical Performance Battery (SPPB)
Timed up and go performance
Other outcome measures
Microvascular flow-induced vasodilation (FID) dose response
Muscle strength
INERTIA Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: InterventionExperimental Treatment1 Intervention
60 Intervention group will receive 12 weeks of supervised resistance training following the American Heart Association and American College of Sports Medicine guidelines for older adults. Exercises will include a mixture of upper-body and lower body strength exercises. Training load will be determined based on initial 1-repetition maximum tests (1-RM). Initial exercise load will start off at low resistance (40-50% 1RM) with more frequent repetitions per exercise, and will gradually increase weight load and intensity over the exercise training period.
Group II: Assessment-only controlActive Control1 Intervention
30 Assessment-only control group will be mailed (standard or electronic) NIH/National Institutes on Aging (NIA) Go4Life® educational materials once a month for 3 months. Exercise logs documenting weekly exercise activities, duration, time and effort will be requested to be sent back.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
progressive resistance training
2012
N/A
~60
Find a Location
Who is running the clinical trial?
University of Illinois at ChicagoLead Sponsor
606 Previous Clinical Trials
1,559,272 Total Patients Enrolled
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,827 Previous Clinical Trials
47,300,750 Total Patients Enrolled
Deepika Laddu, PhDPrincipal Investigator - UIC
University of Illinois at Chicago
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have had cancer, except for non-melanoma skin cancer, and have been treated with radiation or chemotherapy in the past 5 years.You have a bone or joint problem that makes it unsafe to exercise.You can't walk a quarter mile or 400 meters in less than 15 minutes without stopping.You have a history of heart or blood vessel problems like heart attack, stroke, or other serious heart conditions.Lives in the Chicagoland area.You have severe osteoporosis or bone deformities that could make it unsafe for you to do strength training exercises.You live with someone who is already taking part in the study.You are currently drinking a lot of alcohol or using illegal drugs, or you have a history of alcohol or drug problems.Adults who are 60 years old or older, no matter what race they are.You have been diagnosed with dementia, Alzheimer's disease, bipolar disorder, or psychotic disorder, or have been hospitalized for psychological or emotional issues in the past 2 years.You have a medical condition like lupus, multiple sclerosis, or severe rheumatoid arthritis that would make it unsafe for you to exercise.You have good thinking and memory skills, as measured by a test called the MoCA, and you score higher than 22.Adults who don't exercise regularly or don't do strength training.You can walk or exercise without needing a device to help you.
Research Study Groups:
This trial has the following groups:- Group 1: Assessment-only control
- Group 2: Intervention
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Could individuals still apply for enrollment in this research project?
"This investigation, which was initially posted on January 27th 2020, is actively seeking participants according to clinicaltrials.gov. The latest update occurred on June 6th 2022."
Answered by AI
What is the total cohort size of this clinical trial?
"Correct. As per clinicaltrials.gov, this study is actively seeking participants from a single location and aims to recruit 90 patients in total. It was initially posted on January 27th 2020, with the most recent update being made June 6th 2022."
Answered by AI
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