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Exercise Intervention for Aging (REALPA Trial)

N/A

Waitlist Available

Led By Brian Irving, PhD

Research Sponsored by Louisiana State University and A&M College

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measured at week 0 (baseline) and week 16

Awards & highlights

REALPA Trial Summary

This trial examined the effects of resistance exercise (RE) alone or in combination with low intensity physical activity (LPA) breaks on skeletal muscle health in older adults. The results indicated that RE alone or in combination with LPA breaks was effective in improving skeletal muscle health in older adults.

Eligible Conditions

Aging
Sarcopenia
Physical Disabilities
Cardiovascular Disease
Insulin Resistance
Diabetes

REALPA Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measured at week 0 (baseline) and week 16

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measured at week 0 (baseline) and week 16

This trial's timeline: 3 weeks for screening, Varies for treatment, and measured at week 0 (baseline) and week 16 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Skeletal Muscle Mass

Skeletal Muscle Strength

Secondary outcome measures

Mitochondrial Function

REALPA Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Resistance ExerciseExperimental Treatment1 Intervention

Exercise Intervention: Participants will be asked to complete supervised resistance exercise 2 days per week.

Group II: RE plus Low Intensity Physical ActivityExperimental Treatment1 Intervention

Exercise Intervention: Participants will be asked to complete supervised resistance exercise 2 days per week and regular unsupervised low intensity physical activity breaks in sedentary time 5 days per week [6x10 min breaks/d at 2 metabolic equivalents (METS) or ~30-40% peak oxygen consumption (VO2 peak), ~500 kcal/wk above resting metabolism].

Group III: RE plus Moderate IntensityExerciseActive Control1 Intervention

Exercise Intervention: Participants will be asked to complete supervised RE 2 days per week and supervised calorically matched moderate intensity physical activity 3 days per week (50 min/session at 4 METS (~60-75% VO2 peak), ~500 kcal/week above resting metabolism).

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Exercise Intervention

2016

Completed Phase 4

~1330

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

National Institute on Aging (NIA)NIH

1,671 Previous Clinical Trials

28,017,040 Total Patients Enrolled

160 Trials studying Aging

75,984 Patients Enrolled for Aging

Pennington Biomedical Research CenterOTHER

304 Previous Clinical Trials

181,413 Total Patients Enrolled

5 Trials studying Aging

262 Patients Enrolled for Aging

Louisiana State University and A&M CollegeLead Sponsor

9 Previous Clinical Trials

996 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the enrollment phase of this experiment still in progress?

"Affirmative. According to clinicaltrials.gov, this experiment is actively enrolling participants and was initially posted on the 16th of January in 2018. Updates were most recently made on 31st July 2022, with 45 patients required from 2 distinct sites."

Answered by AI

What is the current enrollment capacity of this medical trial?

"Affirmative. Clinicaltrials.gov portrays that this medical investigation, initially posted on January 16th 2018, is actively recruiting patients. 45 subjects need to be enrolled from two distinct clinical sites."

Answered by AI

Are there any prerequisites for inclusion in this experiment?

"Those aged 65 to 80 who have sarcopenia are eligible for this medical experiment. 45 participants in total will be admitted into the trial."

Answered by AI

Are individuals aged forty and above able to participate in this investigation?

"This trial is searching for elderly patients between the ages of 65 and 80 to participant. Per clinicaltrials.gov, there are 240 studies for those under 18 years old and 1638 study that cater to seniors above 65."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health

Brian Irving 2019. "Resistance Exercise and Low-Intensity Physical Activity Breaks in Sedentary Time to Improve Muscle and Cardiometabolic Health". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03771417.