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Celastrol for Safety

N/A
Recruiting
Led By Rubin Patel, MD
Research Sponsored by Legend Labz, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 90 days
Awards & highlights

Study Summary

This trial is to study the safety of Celastrol, a natural occurring compound, in healthy men and women over a 90 day period.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~90 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Liver
Secondary outcome measures
ALT (U/L)
SGOT - Glutamate oxaloacetate transaminase
Absolute Basophils (K/UL)
+39 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Amount of Celastrol AdministeredExperimental Treatment1 Intervention
Chronic evaluation of the same doses of Celastrol to each subject over 90-day period

Find a Location

Who is running the clinical trial?

Legend Labz, Inc.Lead Sponsor
1 Previous Clinical Trials
5 Total Patients Enrolled
Rubin Patel, MDPrincipal InvestigatorPatient Plus Urgent Care
1 Previous Clinical Trials
5 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this endeavor currently seeking participants?

"Clinicaltrials.gov states that this medical trial is still in the process of recruiting patients, after it was first published on May 25th 2022 and updated most recently on August 8th 2022."

Answered by AI

May I be admitted into this clinical experiment?

"Potential participants for this clinical trial should be between the ages of 18 and 40 and adhere to safety guidelines. 35 people in total are being sought out by the study team."

Answered by AI

To what extent has recruitment been successful for this trial?

"Affirmative. Data on clinicaltrials.gov demonstrates that this experiment was posted to the portal on May 25th 2022 and is actively looking for participants, with 35 needing to be recruited from 1 site."

Answered by AI

Is there an age-restriction for participating in this medical experiment?

"Patients that are between 18 and 40 years of age will be eligible for participation in this clinical trial."

Answered by AI
Recent research and studies
PLoS ONEJournal
Development of B Cells and Erythrocytes Is Specifically Impaired by the Drug Celastrol in Mice
Kusy, Sophie, Eliver E. B. Ghosn, Leonore A. Herzenberg, and Christopher H. Contag. 2012. “Development of B Cells and Erythrocytes Is Specifically Impaired by the Drug Celastrol in Mice”. Edited by Christian Schulz. Plos ONE. Public Library of Science (PLoS). doi:10.1371/journal.pone.0035733.
FitoterapiaJournal
Inhibitory Effects of Celastrol on Rat Liver Cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 Activity
Sun, Min, Yu Tang, Tonggui Ding, Mingyao Liu, and Xin Wang. 2014. “Inhibitory Effects of Celastrol on Rat Liver Cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 Activity”. Fitoterapia. Elsevier BV. doi:10.1016/j.fitote.2013.10.004.
European Journal of Medicinal ChemistryJournal
Celastrol: Progresses in Structure-modifications, Structure-activity Relationships, Pharmacology and Toxicology
Hou, Wei, Bo Liu, and Hongtao Xu. 2020. “Celastrol: Progresses in Structure-modifications, Structure-activity Relationships, Pharmacology and Toxicology”. European Journal of Medicinal Chemistry. Elsevier BV. doi:10.1016/j.ejmech.2020.112081.
Journal of Biological ChemistryJournal
Chronic Inhibition of Cardiac Kir2.1 and Herg Potassium Channels by Celastrol with Dual Effects on Both Ion Conductivity and Protein Trafficking
Sun, Haiyan, Xiaodong Liu, Qiaojie Xiong, Sojin Shikano, and Min Li. 2006. “Chronic Inhibition of Cardiac Kir2.1 and Herg Potassium Channels by Celastrol with Dual Effects on Both Ion Conductivity and Protein Trafficking”. Journal of Biological Chemistry. Elsevier BV. doi:10.1074/jbc.m600072200.
~12 spots leftby Apr 2025
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