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Behavioral Intervention

Active neurofeedback for Depression (CNF-rumination Trial)

N/A
Waitlist Available
Led By Jerzy Bodurka, PhD
Research Sponsored by Laureate Institute for Brain Research, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion (average: 2 weeks)
Awards & highlights

CNF-rumination Trial Summary

This trial will help researchers understand if neurofeedback can help people stop ruminating, and if it's effective.

Eligible Conditions
  • Depression
  • Anxiety

CNF-rumination Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion (average: 2 weeks)
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion (average: 2 weeks) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in Brooding subscale of Ruminative Responses Scale (RRS) scores
Functional connectivity change between precuneus and right temporoparietal junction (rTPJ)
Secondary outcome measures
Changes in Depression subscale of Ruminative Responses Scale (RRS) scores
Changes in Reflection subscale of Ruminative Responses Scale (RRS) scores
Changes in sum of Brooding and Depression subscales of Ruminative Responses Scale (RRS) scores
+1 more
Other outcome measures
Changes in Emotion Regulation Questionnaire (ERQ) scores
Changes in Hamilton Anxiety Rating Scale (HAM-A) scores
Changes in Metacognitions Questionnaire (MCQ-30) scores
+9 more

CNF-rumination Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active neurofeedbackExperimental Treatment1 Intervention
Receiving feedback signals from the rumination-related brain functional connectivity.
Group II: Sham neurofeedbackPlacebo Group1 Intervention
Receiving artificially generated feedback signals.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Active neurofeedback
2021
N/A
~50

Find a Location

Who is running the clinical trial?

Laureate Institute for Brain Research, Inc.Lead Sponsor
50 Previous Clinical Trials
5,301 Total Patients Enrolled
17 Trials studying Depression
2,613 Patients Enrolled for Depression
Jerzy Bodurka, PhDPrincipal InvestigatorLaureate Institute for Brain Research
Salvador Guinjoan, MD, PhDPrincipal InvestigatorLaureate Institute for Brain Research

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies for this clinical trial?

"According to clinicaltrials.gov, this trial is not currently on the hunt for participants. It was initially posted in March 2021 and last modified a year later; however, 1339 other trials are presently recruiting patients."

Answered by AI

Is there any possibility for me to join this medical experiment?

"In order to qualify for the study, candidates should possess a diagnosis of depression and fall within the 18-65 age range. The research team is currently looking for 40 test subjects."

Answered by AI

Could you elucidate the principal aims of this clinical trial?

"The aim of this two-week medical trial is to assess changes in the Brooding subscale scores of Ruminative Responses Scale (RRS). Secondary objectives include tracking shifts in Reflection, sum of Brooding and Depression subscales, as well as total score. The maximum achievable score for each area ranges from 5 - 20 for Reflection, 17 - 68 for Brooding/Depression combo, and 22 - 88 on overall scale."

Answered by AI

Does the protocol for this trial include elderly individuals?

"The parameters for inclusion in this trial necessitate that patients be between 18 and 65 years of age. For those who do not meet these requirements, there are 220 studies available to the under-18 demographic and 995 designed for seniors over 65."

Answered by AI

Who else is applying?

What state do they live in?
Texas
How old are they?
18 - 65
What site did they apply to?
Laureate Institute for Brain Research
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Cognitive Process-based Real-time fMRI Neurofeedback in MDD and Rumination
2021. "Cognitive Process-based Real-time fMRI Neurofeedback in MDD and Rumination". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04941066.
~11 spots leftby Apr 2025
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