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PEEP INCREMENTAL for Pulmonary Atelectasis

N/A
Waitlist Available
Led By Robert Kacmarek, RRT, PhD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up study time points: baseline, peep incremental, peep decremental
Awards & highlights

Study Summary

This trial is testing a new way to help obese, intubated patients on mechanical ventilation. The study will use echocardiography and electric impedance tomography to see how well the lungs and heart work together at different levels of positive end-expiratory pressure.

Eligible Conditions
  • Pulmonary Atelectasis
  • Obesity
  • Heart Failure
  • Respiratory Mechanics
  • Respiratory Insufficiency

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~48, 24h before and 24, 48 and 72h after study procedures.
This trial's timeline: 3 weeks for screening, Varies for treatment, and 48, 24h before and 24, 48 and 72h after study procedures. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Respiratory System Elastance
Secondary outcome measures
Lung mechanics - Airway resistances
Lung mechanics - Compliance
Survival
Other outcome measures
Blood pressure
Central venous pressure
Creatinine
+18 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: PEEP_Titration_INCREMENTALExperimental Treatment2 Interventions
The investigators will compare 3 levels of PEEP (BASELINE versus PEEP INCREMENTAL versus PEEP DECREMENTAL). Baseline PEEP is based in the standard of care PEEP used in the participant units. PEEP incremental value is based in transpulmonary pressure. Intervention : PEEP INCREMENTAL
Group II: PEEP_Titration_DECREMENTALExperimental Treatment2 Interventions
The investigators will compare 3 levels of PEEP (BASELINE versus PEEP INCREMENTAL versus PEEP DECREMENTAL). Baseline PEEP is based in the standard of care PEEP used in the participant units. PEEP decremental value is based in lung recruitment maneuver followed by a best compliance curve during PEEP decrements. Intervention :PEEP DECREMENTAL

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,932 Previous Clinical Trials
13,198,469 Total Patients Enrolled
2 Trials studying Pulmonary Atelectasis
95 Patients Enrolled for Pulmonary Atelectasis
Robert Kacmarek, RRT, PhDPrincipal InvestigatorMassachusetts General Hospital
3 Previous Clinical Trials
124 Total Patients Enrolled
1 Trials studying Pulmonary Atelectasis
35 Patients Enrolled for Pulmonary Atelectasis
Lorenzo Berra, MDPrincipal InvestigatorMassachusetts General Hospital
16 Previous Clinical Trials
813 Total Patients Enrolled
1 Trials studying Pulmonary Atelectasis
35 Patients Enrolled for Pulmonary Atelectasis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
American Journal of Respiratory and Critical Care MedicineJournal
The Application of Esophageal Pressure Measurement in Patients with Respiratory Failure
Akoumianaki, Evangelia, Salvatore M. Maggiore, Franco Valenza, Giacomo Bellani, Amal Jubran, Stephen H. Loring, Paolo Pelosi, et al.. 2014. “The Application of Esophageal Pressure Measurement in Patients with Respiratory Failure”. American Journal of Respiratory and Critical Care Medicine. American Thoracic Society. doi:10.1164/rccm.201312-2193ci.
Journal of Applied PhysiologyJournal
Respiratory Restriction and Elevated Pleural and Esophageal Pressures in Morbid Obesity
Behazin, Negin, Stephanie B. Jones, Robert I. Cohen, and Stephen H. Loring. 2010. “Respiratory Restriction and Elevated Pleural and Esophageal Pressures in Morbid Obesity”. Journal of Applied Physiology. American Physiological Society. doi:10.1152/japplphysiol.91356.2008.
Current Opinion in Critical CareJournal
Electrical Impedance Tomography
Costa, Eduardo LV, Raul Gonzalez Lima, and Marcelo BP Amato. 2009. “Electrical Impedance Tomography”. Current Opinion in Critical Care. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/mcc.0b013e3283220e8c.
AnesthesiologyJournal
Prevention of Atelectasis in Morbidly Obese Patients During General Anesthesia and Paralysis
Reinius, Henrik, Lennart Jonsson, Sven Gustafsson, Magnus Sundbom, Olov Duvernoy, Paolo Pelosi, Göran Hedenstierna, and Filip Fredén. 2009. “Prevention of Atelectasis in Morbidly Obese Patients During General Anesthesia and Paralysis”. Anesthesiology. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/aln.0b013e3181b87edb.
~2 spots leftby Apr 2025
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