← Back to Search

Ventilation Strategies for Acute Respiratory Failure (GENIE-Vent Trial)

N/A

Recruiting

Led By Christopher E. Cox, MD

Research Sponsored by Duke University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from study enrollment until hospital discharge or death, whichever comes first, up to 52 weeks

Awards & highlights

GENIE-Vent Trial Summary

This trial will study how different ventilator strategies impact the treatment of patients with acute respiratory failure on ECMO. Patients will be put into two groups and assigned different ventilator protocols to compare the effects.

Who is the study for?

This trial is for patients at Duke University Hospital's Medical ICU who are being treated with ECMO, a life-support machine used when the lungs can't provide enough oxygen on their own. There are no specific exclusion criteria, so all such patients may participate.Check my eligibility

What is being tested?

The study compares two ventilator strategies in the ICU: standard-lung protective ventilation and ultra-lung protective ventilation. It aims to see if different protocols affect patient treatment and whether clinicians will adhere to them during ECMO support.See study design

What are the potential side effects?

Since this trial involves standard medical procedures rather than new medications, side effects relate to potential differences in lung management between the two strategies, which could impact breathing comfort and recovery.

GENIE-Vent Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ from study enrollment until hospital discharge or death, whichever comes first, up to 52 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~from study enrollment until hospital discharge or death, whichever comes first, up to 52 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and from study enrollment until hospital discharge or death, whichever comes first, up to 52 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Protocol fidelity rate

Secondary outcome measures

Duration of ECMO

Duration of Hospital admission

Duration of ICU admission

+4 more

GENIE-Vent Trial Design

2Treatment groups

Active Control

Group I: Ultra-Lung Protective VentilationActive Control1 Intervention

Group II: Standard-Lung Protective VentilationActive Control1 Intervention

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Duke UniversityLead Sponsor

2,363 Previous Clinical Trials

3,420,466 Total Patients Enrolled

Christopher E. Cox, MDPrincipal InvestigatorDuke University

Media Library

Standard-Lung Protective Ventilation Clinical Trial Eligibility Overview. Trial Name: NCT05708365 — N/A

Acute Respiratory Distress Syndrome Research Study Groups: Ultra-Lung Protective Ventilation, Standard-Lung Protective Ventilation

Acute Respiratory Distress Syndrome Clinical Trial 2023: Standard-Lung Protective Ventilation Highlights & Side Effects. Trial Name: NCT05708365 — N/A

Standard-Lung Protective Ventilation 2023 Treatment Timeline for Medical Study. Trial Name: NCT05708365 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals being accepted to participate in this investigation currently?

"According to the clinicaltrials.gov database, this research is actively looking for volunteers as of March 1st 2023; a date that coincides with its last update on the same day."

Answered by AI

What is the current scope of participants in this clinical trial?

"Confirmed. Clinicaltrials.gov demonstrates that this medical research was first launched on March 1st, 2023 and is still recruiting participants. At present, the trial requires a total of twenty individuals from one single site to join in."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Generating Evidence in ECMO Ventilation Strategies

2023. "Generating Evidence in ECMO Ventilation Strategies". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05708365.

All > Ecmo > Ards