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Adaptive Pressure Control for Acute Respiratory Distress Syndrome (PIVOT-1 Trial)

N/A

Waitlist Available

Led By Kevin Gibbs, MD

Research Sponsored by Wake Forest University Health Sciences

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 28 days

Awards & highlights

PIVOT-1 Trial Summary

This trial will study whether it's feasible to use a different protocol for mechanical ventilation in the medical intensive care unit. The new protocol would be called "assist volume control ventilation" and it would be compared to the current standard, "adaptive pressure control."

Eligible Conditions

Acute Respiratory Distress Syndrome (ARDS)
Respiratory Failure
Ventilator Associated Lung Injury

PIVOT-1 Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 28 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~28 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 28 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Percentage of patients receiving Assist Volume Control

Secondary outcome measures

Number of ventilator free days

Percentage of mode crossover

assist volume control duration

+2 more

PIVOT-1 Trial Design

2Treatment groups

Active Control

Group I: Adaptive Pressure ControlActive Control1 Intervention

The Adaptive Pressure Control arm is the baseline mode/protocol for medical intensive care unit mechanical ventilation

Group II: Assist Volume ControlActive Control1 Intervention

The assist volume control arm is the new protocol that will be implemented and tested for feasibility

Do I qualify?Apply below to find out

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Who is running the clinical trial?

Wake Forest University Health SciencesLead Sponsor

1,241 Previous Clinical Trials

1,004,098 Total Patients Enrolled

Kevin Gibbs, MDPrincipal InvestigatorWake Forest University Health Sciences

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this experiment presently looking to enroll new participants?

"The records on clinicaltrials.gov reveal that this medical trial is not currently open to patient recruitment, having been published in September 2019 and last amended in February 2022. Despite the closure of this study, 357 other trials are actively recruiting participants right now."

Answered by AI

Recent research and studies

Critical Care Nursing QuarterlyJournal

Advanced Ventilator Modes and Techniques

Haas, Carl F., and Kimberly A. Bauser. 2012. “Advanced Ventilator Modes and Techniques”. Critical Care Nursing Quarterly. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/cnq.0b013e31823b2670.

Frontiers in PhysiologyJournal

Characterizing and Modeling Breathing Dynamics: Flow Rate, Rhythm, Period, and Frequency

Napoli, Nicholas J., Victoria R. Rodrigues, and Paul W. Davenport. 2022. “Characterizing and Modeling Breathing Dynamics: Flow Rate, Rhythm, Period, and Frequency”. Frontiers in Physiology. Frontiers Media SA. doi:10.3389/fphys.2021.772295.

Critical Care MedicineJournal

ICU Occupancy and Mechanical Ventilator Use in the United States*

Wunsch, Hannah, Jason Wagner, Maximilian Herlim, David H. Chong, Andrew A. Kramer, and Scott D. Halpern. 2013. “ICU Occupancy and Mechanical Ventilator Use in the United States*”. Critical Care Medicine. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/ccm.0b013e318298a139.

JamaJournal