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Sigh breaths for Acute Respiratory Distress Syndrome (SiVent Trial)

N/A
Waitlist Available
Led By Richard Albert, MD
Research Sponsored by University of Minnesota
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 28 days
Awards & highlights

SiVent Trial Summary

This trial will assess if adding sigh breaths to usual invasive mechanical ventilation will decrease the number of days patients require mechanical ventilation.

Eligible Conditions
  • Acute Respiratory Distress Syndrome

SiVent Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~28 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 28 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Ventilator-free days (VFDs)
Secondary outcome measures
All-cause mortality
ICU-free days
Newly requiring continuous oxygen therapy at discharge
+2 more

SiVent Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Sigh breathsExperimental Treatment1 Intervention
Sigh breaths consisting of a Tidal volume (VT) that produces a plateau pressure (Pplat) of 35 cmH2O (or 40 cmH2O in patients with BMIs > 35 or in patients with moderate or severe abdominal distension from ascites, blood and/or ileum, or prone patients). The sigh breaths will be delivered once every 6 minutes, as part of usual invasive mechanical ventilation.
Group II: Usual CareActive Control1 Intervention
Usual care, meaning that the treating physician will be free to treat the patient in any way he or she sees fit, including utilizing invasive mechanical ventilation as they wish.

Find a Location

Who is running the clinical trial?

University of MinnesotaLead Sponsor
1,375 Previous Clinical Trials
1,587,851 Total Patients Enrolled
United States Department of DefenseFED
859 Previous Clinical Trials
224,974 Total Patients Enrolled
University of Colorado, DenverOTHER
1,731 Previous Clinical Trials
2,144,073 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome
2016. "Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02582957.
~58 spots leftby Apr 2025
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