← Back to Search

Gas

Hypoxic Breathing Safety Study for Healthy Volunteers (MGH-nitrogen Trial)

N/A
Waitlist Available
Led By Lorenzo Berra, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Male or female individuals age between 18 and 40 years old
Male or female individuals age between 18 and 40 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7 days
Awards & highlights

MGH-nitrogen Trial Summary

This trial will look at how safe and effective it is to expose healthy volunteers to low-oxygen environments.

Who is the study for?
Healthy adults aged 18-40 with a BMI of 19-24.9, able to consent and provide photo ID can join this trial. It's not for those born or living at high altitudes, heavy drinkers, pregnant women, smokers, or anyone with certain medical conditions like uncontrolled hypertension or diabetes.Check my eligibility
What is being tested?
The study tests the safety of breathing low-oxygen air (inhaled nitrogen) in a controlled environment among healthy volunteers to understand how their bodies respond over time.See study design
What are the potential side effects?
Potential side effects may include symptoms related to low oxygen levels such as dizziness, shortness of breath, headache, and increased heart rate. The full extent will be monitored throughout the study.

MGH-nitrogen Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 40 years old.
Select...
I am between 18 and 40 years old.
Select...
I am able to understand and agree to participate in the study.

MGH-nitrogen Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Peripheral oxygen saturation
Secondary outcome measures
Acid-base status
Anaerobiotic glycolytic pathway
Energy metabolism
+6 more

MGH-nitrogen Trial Design

1Treatment groups
Experimental Treatment
Group I: Inhaled NitrogenExperimental Treatment1 Intervention
A humidified mixture of gas will be delivered by mask, nasal cannulae, and small room-sized tent. Inspiratory oxygen fraction (FiO2) will be gradually decreased to 11% over a period or five days to obtain a peripheral capillary O2 saturation (SpO2) between 80%-85% (corresponding to 40-55 mmHg of arterial partial oxygen pressure (PaO2)). Healthy volunteers will be monitored and blood and urine will be obtained at 24h and 48 hours after returning to normoxia.

Find a Location

Who is running the clinical trial?

Zapol, Warren M., M.D., Massachusetts General Hospital, Harvard Medical SchoolUNKNOWN
Fisher, Daniel, R.R.T., Massachusetts General Hospital, Harvard Medical SchoolUNKNOWN
Harris, Stuart N., M.D., Massachusetts General Hospital, Harvard Medical SchoolUNKNOWN

Media Library

Inhaled Nitrogen (Gas) Clinical Trial Eligibility Overview. Trial Name: NCT02860975 — N/A
Healthy Subjects Research Study Groups: Inhaled Nitrogen
Healthy Subjects Clinical Trial 2023: Inhaled Nitrogen Highlights & Side Effects. Trial Name: NCT02860975 — N/A
Inhaled Nitrogen (Gas) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02860975 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What criteria must be met in order to partake in this clinical trial?

"To be accepted into this trial, applicants must have a healthy subject status and an age between 18 and 40. The medical study is expected to accept 12 participants in total."

Answered by AI

Is this experiment open to participants of sixty years or older?

"This research study is only open to individuals aged 18-40. Conversely, there are 65 trials for those younger than 18 and 453 studies available for participants older than 65 years of age."

Answered by AI

Are patients currently being admitted to participate in this clinical experiment?

"Clinicaltrials.gov has marked this investigation as inactive, noting that it was posted in January 1st 2017 and last updated on October 31st 2022. In spite of this trial's status, there are numerous other clinical experiments presently recruiting volunteers."

Answered by AI

Who else is applying?

What state do they live in?
Virginia
Massachusetts
How old are they?
18 - 65
What site did they apply to?
Massachusetts General Hospital
What portion of applicants met pre-screening criteria?
Met criteria
~2 spots leftby Oct 2025