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Intervention Arm for Chronic Kidney Disease

N/A
Waitlist Available
Led By Christopher McIntyre, MD
Research Sponsored by Lawson Health Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

Patients who receive dialysis for kidney failure suffer severe cognitive impairment. Hemodialysis causes circulatory stress and ischemia, which causes severe brain injury. It has been demonstrated that a procedure known as Remote Ischemic Preconditioning(RIPC), which involves wrapping a blood pressure cuff around a patient's leg and inflating has the potential of protecting many organs, such as the heart from the effects of dialysis. Our study aims to investigate this phenomenon to determine the extent to which it provides protection to a dialysis patient's brain.

Eligible Conditions
  • Chronic Kidney Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Neuro-protection against functionally significant new brain injury
Secondary outcome measures
Blood work- blood count
Blood work- electrolytes
Blood
+13 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Intervention ArmExperimental Treatment1 Intervention
RIPC stimulus will be applied prior to the first intervention visit, using a previously validated (for cardiac protection in HD patients) standard dose (four cycles of cuff inflation to the lower limb of the patient and inflating at 200mmHg for five minutes, with five minutes' deflation). To be administered on a monthly basis from the baseline visit to the year 1 visit.
Group II: Control ArmPlacebo Group1 Intervention
Sham procedure in which the blood pressure cuff will be applied to the lower limb and inflated to 40mmHg for five minutes and deflated for five minutes with the cycle repeated a total of four times prior to dialysis. To be administered on a monthly basis from the baseline visit to the year 1 visit.

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Who is running the clinical trial?

Lawson Health Research InstituteLead Sponsor
658 Previous Clinical Trials
413,633 Total Patients Enrolled
Christopher McIntyre, MDPrincipal InvestigatorLondon Health Sciences Centre

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Reducing Hemodialysis Induced Recurrent Brain Injury to Improve Patients' Lives
Chris McIntyre 2018. "Reducing Hemodialysis Induced Recurrent Brain Injury to Improve Patients' Lives". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03342183.
~3 spots leftby Apr 2025
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