← Back to Search

Stem Cell Transplantation

Stem Cell Transplant for Autoimmune Diseases

N/A

Waitlist Available

Research Sponsored by Fairview University Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Prior response to immunosuppressive therapy

Arthritis of 3 or more joint areas

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Study Summary

This trial is testing whether a combination of plasmapheresis, high dose cyclophosphamide, and total lymphoid irradiation followed by autologous peripheral blood stem cell transplantation using filgrastim (G-CSF) mobilization and posttransplant immunosuppression with cyclosporine can improve the clinical course of life-threatening autoimmune diseases.

Who is the study for?

This trial is for patients with severe autoimmune diseases like various types of arthritis, anemia, vasculitis, and lupus. Participants must meet specific criteria such as age limits for juvenile rheumatoid arthritis and certain blood count levels for anemia. They should have tried conventional therapies without success but had some response to immunosuppressive treatments.Check my eligibility

What is being tested?

The study tests if a stem cell transplant can help people with life-threatening autoimmune diseases. It involves stimulating the growth of new cells with filgrastim (G-CSF), removing plasma from the blood, high-dose chemotherapy, radiation therapy targeting lymph nodes, and post-transplant drugs like cyclosporine to prevent rejection.See study design

What are the potential side effects?

Potential side effects include complications from low blood counts like bleeding or infections due to bone marrow suppression by chemotherapy and radiation; organ inflammation; reactions during infusion; fatigue; nausea; hair loss; mouth sores from chemotherapy.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have responded well to treatments that suppress my immune system.

Select...

I have arthritis in three or more of my joints.

Select...

My condition limits my physical activity but I can still perform light tasks.

Select...

I have a butterfly-shaped rash on my face.

Select...

One of my internal organs is at risk due to my condition.

Select...

I have anemia caused by a specific decrease in early red blood cell precursors.

Select...

My tests show a positive reaction to immune system suppression.

Select...

My condition did not improve after trying all standard treatments.

Select...

I have swelling or fluid in one or more of my joints.

Select...

I have a blood disorder caused by my immune system.

Select...

My condition didn't improve after trying at least 2 treatments, including prednisone.

Select...

I do not have any symptoms related to heart disease.

Select...

I do not have active heart disease.

Select...

My blood pressure is under control.

Select...

I have an immune system disorder.

Select...

I have arthritis in my hand joints.

Select...

I am at high risk for severe joint disease or have a serious condition affecting an internal organ.

Select...

I have a round, red rash on my skin.

Select...

I have inflammation in the lining of my organs.

Select...

I have a neurological disorder.

Select...

I have been diagnosed with a specific type of vasculitis.

Select...

I have heart muscle or inner heart lining disease.

Select...

I have a lung condition affecting the tissue and space around the air sacs.

Select...

I am fully active or can carry out light work.

Select...

I do not have a history of severe liver disease.

Select...

My child's oxygen level is above 94% without doing a lung function test.

Select...

My diabetes is under control.

Select...

I have received another immune-suppressing treatment after having my spleen removed.

Select...

I have a condition where my immune system attacks my red blood cells.

Select...

I have arthritis in the same joints on both sides of my body.

Select...

I have at least 16 swollen or tender joints.

Select...

My condition has been present for 6 weeks or more.

Select...

My lung function tests show I breathe well enough.

Select...

I do not have any active brain conditions unrelated to my cancer.

Select...

My platelet count is below 20,000 due to an autoimmune condition.

Select...

I have had my spleen removed.

Select...

My arthritis started before I turned 16.

Select...

I have had a life-threatening bleeding event in the past.

Select...

I have heart or chest lining disease.

Select...

I have lumps under my skin due to my rheumatoid arthritis.

Select...

My kidney function is within the required range.

Select...

I have active rheumatoid arthritis.

Select...

I have sores in my mouth.

Select...

I have been diagnosed with a specific type of juvenile arthritis.

Select...

I have a condition affecting my brain or spinal cord.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

0 / 45Eligibility criteria met

Find a Location

Who is running the clinical trial?

Fairview University Medical CenterLead Sponsor

6 Previous Clinical Trials

50 Total Patients Enrolled

Arne SlungaardStudy ChairFairview University Medical Center

Media Library

Autologous Peripheral Blood Stem Cell Transplantation (Stem Cell Transplantation) Clinical Trial Eligibility Overview. Trial Name: NCT00006055 — N/A

Graft-versus-Host Disease Research Study Groups:

Graft-versus-Host Disease Clinical Trial 2023: Autologous Peripheral Blood Stem Cell Transplantation Highlights & Side Effects. Trial Name: NCT00006055 — N/A

Autologous Peripheral Blood Stem Cell Transplantation (Stem Cell Transplantation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00006055 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What eligibility criteria must individuals meet to be admitted into this clinical investigation?

"This investigation is seeking 10 participants with hypersensitivity vasculitis aged between 1 and 55 Years."

Answered by AI

Are there any unfilled vacancies in this research endeavor?

"It appears that this medical study is not looking for further enrolment at present; it was initially posted on March 1st 2000 and modified most recently in June 23rd 2005. However, there are currently over a thousand other clinical trials actively recruiting patients."

Answered by AI