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Argon Plasma Coagulation for Recurrence (SAP Trial)

N/A
Waitlist Available
Led By Douglas K. Rex, MD
Research Sponsored by Indiana University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 day
Awards & highlights

SAP Trial Summary

This trial is testing whether using a certain type of endoscopic tool (STSC or APC) or no tool at all is better for patients undergoing EMR for lesions 15mm or larger.

SAP Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 day
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 day for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Recurrence
Types of Recurrences
Secondary outcome measures
Complications
Time

SAP Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Snare Tip Soft CoagulationExperimental Treatment1 Intervention
Following polyp removal using standard of care methods, Snare Tip Soft Coagulation (STSC) will be applied to the perimeter of the resection site before any clips are added.
Group II: Argon Plasma CoagulationExperimental Treatment1 Intervention
Following polyp removal using standard of care methods, Argon Plasma Coagulation (APC) will be applied to the perimeter of the resection site before any clips are added.
Group III: No treatmentActive Control1 Intervention
Following polyp removal using standard of care methods, neither APC nor STSC will be applied to the perimeter of the resection site. Clips may be added at the discretion of the PI.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Argon Plasma Coagulation
2007
Completed Phase 4
~540
Snare Tip Soft Coagulation
2013
N/A
~840

Find a Location

Who is running the clinical trial?

Indiana UniversityLead Sponsor
980 Previous Clinical Trials
982,776 Total Patients Enrolled
10 Trials studying Recurrence
3,281 Patients Enrolled for Recurrence
Erbe USA IncorporatedOTHER
9 Previous Clinical Trials
717 Total Patients Enrolled
Douglas K. Rex, MD4.733 ReviewsPrincipal Investigator - Indiana University
Indiana University
5Patient Review
Dr Rex is an excellent doctor who excels in communication, empathy, and technical skill. I feel lucky to be one of his patients.

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Gastrointestinal EndoscopyJournal
Treatment with Argon Plasma Coagulation Reduces Recurrence After Piecemeal Resection of Large Sessile Colonic Polyps: A Randomized Trial and Recommendations
Brooker, Jim C., Brian P. Saunders, Syed G. Shah, Catherine J. Thapar, Noriko Suzuki, and Christopher B. Williams. 2002. “Treatment with Argon Plasma Coagulation Reduces Recurrence After Piecemeal Resection of Large Sessile Colonic Polyps: A Randomized Trial and Recommendations”. Gastrointestinal Endoscopy. Elsevier BV. doi:10.1067/mge.2002.121597.
EndoscopyJournal
Cold-forceps Avulsion with Adjuvant Snare-tip Soft Coagulation (CAST) Is an Effective and Safe Strategy for the Management of Non-lifting Large Laterally Spreading Colonic Lesions
Tate, David, Farzan Bahin, Lobke Desomer, Mayenaaz Sidhu, Vikas Gupta, and Michael Bourke. 2017. “Cold-forceps Avulsion with Adjuvant Snare-tip Soft Coagulation (CAST) Is an Effective and Safe Strategy for the Management of Non-lifting Large Laterally Spreading Colonic Lesions”. Endoscopy. Georg Thieme Verlag KG. doi:10.1055/s-0043-119215.
DigestionJournal
Risk Factors for Local Recurrence of Large, Flat Colorectal Polyps After Endoscopic Mucosal Resection
Zhan, Tianzuo, Thomas Hielscher, Felix Hahn, Corinna Hauf, Johannes Betge, Matthias P. Ebert, and Sebastian Belle. 2016. “Risk Factors for Local Recurrence of Large, Flat Colorectal Polyps After Endoscopic Mucosal Resection”. Digestion. S. Karger AG. doi:10.1159/000446364.
clinicaltrials.govStudy
Post-resection Treatment of Large Colon Polyps
Douglas K. Rex 2018. "Post-resection Treatment of Large Colon Polyps". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03654209.
~59 spots leftby Apr 2025
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